A vector-host model for dengue fever incorporating the dynamics of antibodies and viral load

Debora de Oliveira Medeiros (FGV)

 

Data: 11 de setembro de 2025

Horário: 10h00

Local: Online

Transmissão: https://meet.google.com/vve-dnek-jvn

Resumo

We present a new structured mathematical model as part of a larger project aimed at investigating dengue reinfections as the Antibody-Dependent Enhancement (ADE) phenomenon, and also optimal control strategies. The proposed vector-host model integrates viral load and antibody micro dynamics to characterize new infections.

We examine a specific case that leads to an associated model, analyzing its endemic equilibrium and basic reproduction number through theoretical and numerical studies. These initial findings align with expected epidemiological behavior, providing a foundation for the further development of models to explore ADE dynamics and to study effective strategies for controlling dengue.

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