{"id":4187,"date":"2025-01-04T03:36:19","date_gmt":"2025-01-04T05:36:19","guid":{"rendered":"https:\/\/sites.usp.br\/bpeanimal\/?page_id=4187"},"modified":"2025-06-25T19:09:40","modified_gmt":"2025-06-25T21:09:40","slug":"ratones-administracion-de-sustancias-via-oral-sonda","status":"publish","type":"page","link":"https:\/\/sites.usp.br\/bpeanimal\/es\/boas-praticas-em-experimentacao-animal-espanol\/ratones\/ratones-administracion-de-sustancias\/ratones-administracion-de-sustancias-via-oral-sonda\/","title":{"rendered":"Ratones &#8211; Administraci\u00f3n de sustancias &#8211; V\u00eda oral (Canulaci\u00f3n por sonda)"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"4187\" class=\"elementor elementor-4187\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-71b8ebb elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"71b8ebb\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-85f7dc1\" data-id=\"85f7dc1\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-92a928c elementor-widget elementor-widget-video\" data-id=\"92a928c\" data-element_type=\"widget\" data-settings=\"{&quot;youtube_url&quot;:&quot;https:\\\/\\\/youtu.be\\\/KjDnGGiwpas&quot;,&quot;video_type&quot;:&quot;youtube&quot;,&quot;controls&quot;:&quot;yes&quot;}\" data-widget_type=\"video.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-wrapper elementor-open-inline\">\n\t\t\t<div class=\"elementor-video\"><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-616690a elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"616690a\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-e92fdde\" data-id=\"e92fdde\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-650f794 elementor-widget elementor-widget-heading\" data-id=\"650f794\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Administraci\u00f3n de sustancias\u200b<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d2acbb2 elementor-widget elementor-widget-heading\" data-id=\"d2acbb2\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">V\u00eda oral (Canulaci\u00f3n por sonda)\n<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bf01fc9 elementor-widget elementor-widget-text-editor\" data-id=\"bf01fc9\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><span style=\"background-color: inherit;\"><b>Materiales<\/b><\/span><b>:<\/b><\/p><ul><li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Guantes descartables para los procedimientos;<\/span><\/li><li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Bata de laboratorio;<\/span><\/li><li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sonda r\u00edgida o flexible compatible con el tama\u00f1o del animal (largo y calibre);<\/span><\/li><li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Jeringa (de 1 ml a 3 ml).<\/span><\/li><\/ul><p><b>Procedimientos:<\/b><\/p><ol><li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">La c\u00e1nula que va a ser utilizada deber\u00e1 tener el largo adecuado al tama\u00f1o del rat\u00f3n, considerando la distancia a partir de la comisura de la boca hasta la \u00faltima costilla del animal;<\/span><\/li><li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Rellene la jeringa con la cantidad apropiada de la sustancia que se va a administrar;<\/span><\/li><li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Realice la inmovilizaci\u00f3n manual del rat\u00f3n, seg\u00fan lo descrito en la t\u00e9cnica I de contenci\u00f3n y col\u00f3quelo con la cabeza orientada hacia arriba. La cabeza debe estar completamente inmovilizada para permitir el posicionamiento adecuado de la sonda de canulaci\u00f3n;\u00a0<\/span><\/li><li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Mida la porci\u00f3n de la c\u00e1nula que desea introducir, considerando la distancia desde la cavidad oral hasta el est\u00f3mago del animal (aproximadamente a la altura del cart\u00edlago xifoides);<\/span><\/li><li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Introduzca la punta de la c\u00e1nula por la comisura lateral de la boca (evitando los dientes incisivos) y deslice la c\u00e1nula dentro de la cavidad oral, por encima de la lengua del animal, realizando un movimiento delicado y continuo;<\/span><\/li><li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Espere hasta que el animal trague. Cuando est\u00e1 correctamente posicionada, la c\u00e1nula se desliza f\u00e1cilmente por el es\u00f3fago del animal. Nunca ejerza fuerza durante el procedimiento, ya que podr\u00eda causar ruptura del es\u00f3fago;<\/span><\/li><li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Una vez que la c\u00e1nula est\u00e9 debidamente colocada, administre lentamente la sustancia observando que no haya reflujo;<\/span><\/li><li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Remueva la c\u00e1nula lentamente, siguiendo la misma curvatura con la cual fue introducida.<\/span><\/li><li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Observe si el animal presenta alg\u00fan signo de dificultad para respirar o sangrado por la boca o narinas por lo menos 5 minutos, antes de devolverlo a la sala de alojamiento en el bioterio.<\/span><\/li><\/ol>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-77571fa elementor-widget elementor-widget-text-editor\" data-id=\"77571fa\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p style=\"background-color: #fee8e8;\"><span style=\"color: #ff0000;\"><b>ATENCI\u00d3N<\/b><\/span><\/p><p style=\"background-color: #fee8e8;\"><span style=\"font-weight: 400; color: #ff0000;\">La canulaci\u00f3n debe realizarse en animales sin anestesia o sedaci\u00f3n, debido al mayor riesgo de aspiraci\u00f3n, porque la soluci\u00f3n puede entrar inadvertidamente en los pulmones.<\/span><\/p><p style=\"background-color: #fee8e8;\"><span style=\"font-weight: 400; color: #ff0000;\">Si se produce hipo o tos, puede ser indicativo de que la c\u00e1nula est\u00e1 en la tr\u00e1quea del animal.<\/span><\/p><p style=\"background-color: #fee8e8;\"><span style=\"font-weight: 400; color: #ff0000;\">Las c\u00e1nulas deber\u00e1n tener la punta roma para evitar que se deslice por la tr\u00e1quea y para evitar lesiones. De forma alternativa, podr\u00eda utilizarse una c\u00e1nula flexible.<\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-496408d elementor-widget elementor-widget-text-editor\" data-id=\"496408d\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><strong>Referencia:<\/strong><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7d43374 elementor-widget elementor-widget-text-editor\" data-id=\"7d43374\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<pre><span style=\"font-weight: 400;\">BOGDANSKE, John J. et al. Laboratory mouse procedural techniques: manual and DVD. CRC Press, 2010. DOI:\u00a0<\/span><a style=\"font-family: var( --e-global-typography-text-font-family ), Sans-serif; font-weight: var( --e-global-typography-text-font-weight );\" href=\"https:\/\/www.taylorfrancis.com\/books\/mono\/10.1201\/9780429187940\/laboratory-mouse-laboratory-rat-procedural-techniques-john-bogdanske\" target=\"_blank\" rel=\"noopener\">10.1201\/9780429187940<\/a><span style=\"color: var( --e-global-color-text ); font-family: var( --e-global-typography-text-font-family ), Sans-serif;\">\u00a0<\/span><\/pre>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-af1d482 elementor-hidden-desktop elementor-hidden-tablet elementor-hidden-mobile elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"af1d482\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-b2a46a4\" data-id=\"b2a46a4\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4715a9c elementor-widget elementor-widget-text-editor\" data-id=\"4715a9c\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>\n<table id=\"tablepress-1\" class=\"tablepress tablepress-id-1\">\n<thead>\n<tr class=\"row-1\">\n\t<th class=\"column-1\"><strong>Peso do animal (gramas)<\/strong><\/th><th class=\"column-2\"><strong>Calibre da c\u00e2nula (mm)<\/strong><\/th><th class=\"column-3\"><strong>Comprimento (cm)<\/strong><\/th><th class=\"column-4\"><strong>Di\u00e2metro da esfera (mm)<\/strong><\/th><th class=\"column-5\"><strong>Formato<\/strong><\/th>\n<\/tr>\n<\/thead>\n<tbody class=\"row-striping row-hover\">\n<tr class=\"row-2\">\n\t<td class=\"column-1\">At\u00e9 14<\/td><td class=\"column-2\">0,511 (24 G)<\/td><td class=\"column-3\">2.5<\/td><td class=\"column-4\">31.75<\/td><td class=\"column-5\">reta<\/td>\n<\/tr>\n<tr class=\"row-3\">\n\t<td class=\"column-1\">15-20<\/td><td class=\"column-2\">0,644 (22 G)<\/td><td class=\"column-3\">2, 5 a 3,5<\/td><td class=\"column-4\">31.75<\/td><td class=\"column-5\">reta<\/td>\n<\/tr>\n<tr class=\"row-4\">\n\t<td class=\"column-1\">20-25<\/td><td class=\"column-2\">0,812 (20 G)<\/td><td class=\"column-3\">2,5 a 5,0<\/td><td class=\"column-4\">57.15<\/td><td class=\"column-5\">reta, curva<\/td>\n<\/tr>\n<tr class=\"row-5\">\n\t<td class=\"column-1\">25-30<\/td><td class=\"column-2\">1,024 (18 G)<\/td><td class=\"column-3\">2,5 a 7,5<\/td><td class=\"column-4\">57.15<\/td><td class=\"column-5\">reta, curva<\/td>\n<\/tr>\n<tr class=\"row-6\">\n\t<td class=\"column-1\">30-35<\/td><td class=\"column-2\">1,024 (18 G)<\/td><td class=\"column-3\">5 a 7,5<\/td><td class=\"column-4\">57.15<\/td><td class=\"column-5\">reta, curva<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Administraci\u00f3n de sustancias\u200b V\u00eda oral (Canulaci\u00f3n por sonda) Materiales: Guantes descartables para los procedimientos; Bata de laboratorio; Sonda r\u00edgida o flexible compatible con el tama\u00f1o del animal (largo y calibre); Jeringa (de 1 ml a 3 ml). Procedimientos: La c\u00e1nula que va a ser utilizada deber\u00e1 tener el largo adecuado al tama\u00f1o del rat\u00f3n, considerando [&hellip;]<\/p>\n","protected":false},"author":23772,"featured_media":0,"parent":3888,"menu_order":12,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-4187","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/sites.usp.br\/bpeanimal\/wp-json\/wp\/v2\/pages\/4187","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.usp.br\/bpeanimal\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.usp.br\/bpeanimal\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.usp.br\/bpeanimal\/wp-json\/wp\/v2\/users\/23772"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.usp.br\/bpeanimal\/wp-json\/wp\/v2\/comments?post=4187"}],"version-history":[{"count":4,"href":"https:\/\/sites.usp.br\/bpeanimal\/wp-json\/wp\/v2\/pages\/4187\/revisions"}],"predecessor-version":[{"id":5031,"href":"https:\/\/sites.usp.br\/bpeanimal\/wp-json\/wp\/v2\/pages\/4187\/revisions\/5031"}],"up":[{"embeddable":true,"href":"https:\/\/sites.usp.br\/bpeanimal\/wp-json\/wp\/v2\/pages\/3888"}],"wp:attachment":[{"href":"https:\/\/sites.usp.br\/bpeanimal\/wp-json\/wp\/v2\/media?parent=4187"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}