{"id":79,"date":"2014-02-24T16:51:20","date_gmt":"2014-02-24T18:51:20","guid":{"rendered":"http:\/\/sites.usp.br\/hoch\/?page_id=79"},"modified":"2024-08-02T17:25:16","modified_gmt":"2024-08-02T19:25:16","slug":"pagina-inicial","status":"publish","type":"page","link":"https:\/\/sites.usp.br\/hoch\/en\/","title":{"rendered":"Welcome to the Genomic Stability Lab website!"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"79\" class=\"elementor elementor-79\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-7cd6d0d7 elementor-section-height-min-height elementor-section-content-middle elementor-section-boxed elementor-section-height-default elementor-section-items-middle\" data-id=\"7cd6d0d7\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-1b275c5b\" data-id=\"1b275c5b\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-60d379c3 elementor-widget elementor-widget-text-editor\" data-id=\"60d379c3\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-size: 23px;\">N\u00f3s estudamos como c\u00e9lulas sinalizam e reparam danos ao nosso material gen\u00e9tico, o DNA. Em <\/span><span style=\"font-size: 23px;\">especial, temos interesse em como uma modifica\u00e7\u00e3o p\u00f3s-traducional chamada <b>ADP-ribosila\u00e7\u00e3o<\/b>\u00a0<\/span><span style=\"font-size: 23px;\">acelera os processos de reparo, e em como muta\u00e7\u00f5es em genes envolvidos na sinaliza\u00e7\u00e3o e reparo\u00a0<\/span><span style=\"font-size: 23px;\">de DNA causam doen\u00e7as gen\u00e9ticas raras caracterizadas por <b>neurodegenera\u00e7\u00e3o<\/b>, <b>predisposi\u00e7\u00e3o ao\u00a0<\/b><\/span><span style=\"font-size: 23px;\"><b>c\u00e2ncer<\/b> e <b>envelhecimento precoce<\/b>.<\/span><\/p><p><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4f462c91 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"4f462c91\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-3b8b2c8c\" data-id=\"3b8b2c8c\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4fca368 elementor-widget elementor-widget-image\" data-id=\"4fca368\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"604\" height=\"451\" src=\"https:\/\/sites.usp.br\/hoch\/wp-content\/uploads\/sites\/725\/2020\/06\/LT-63x-Z1-deconv-1024x765.jpg\" class=\"attachment-large size-large wp-image-153\" alt=\"\" srcset=\"https:\/\/sites.usp.br\/hoch\/wp-content\/uploads\/sites\/725\/2020\/06\/LT-63x-Z1-deconv-1024x765.jpg 1024w, https:\/\/sites.usp.br\/hoch\/wp-content\/uploads\/sites\/725\/2020\/06\/LT-63x-Z1-deconv-300x224.jpg 300w, https:\/\/sites.usp.br\/hoch\/wp-content\/uploads\/sites\/725\/2020\/06\/LT-63x-Z1-deconv-768x574.jpg 768w, https:\/\/sites.usp.br\/hoch\/wp-content\/uploads\/sites\/725\/2020\/06\/LT-63x-Z1-deconv-80x60.jpg 80w, https:\/\/sites.usp.br\/hoch\/wp-content\/uploads\/sites\/725\/2020\/06\/LT-63x-Z1-deconv-400x299.jpg 400w, https:\/\/sites.usp.br\/hoch\/wp-content\/uploads\/sites\/725\/2020\/06\/LT-63x-Z1-deconv.jpg 1392w\" sizes=\"(max-width: 604px) 100vw, 604px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\"> Microscopia de fluoresc\u00eancia de c\u00e9lulas humanas em cultura. Azul: DNA no n\u00facleo da c\u00e9lulas, verde: filamentos de actina, vermelho: mitoc\u00f4ndrias. <\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-318d343b elementor-section-height-min-height elementor-section-content-middle elementor-reverse-mobile elementor-section-boxed elementor-section-height-default elementor-section-items-middle\" data-id=\"318d343b\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;none&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-86ff9eb\" data-id=\"86ff9eb\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8af89b2 elementor-widget elementor-widget-image\" data-id=\"8af89b2\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"604\" height=\"443\" src=\"https:\/\/sites.usp.br\/hoch\/wp-content\/uploads\/sites\/725\/2020\/06\/SCE-green.jpg\" class=\"attachment-large size-large wp-image-163\" alt=\"\" srcset=\"https:\/\/sites.usp.br\/hoch\/wp-content\/uploads\/sites\/725\/2020\/06\/SCE-green.jpg 1011w, https:\/\/sites.usp.br\/hoch\/wp-content\/uploads\/sites\/725\/2020\/06\/SCE-green-300x220.jpg 300w, https:\/\/sites.usp.br\/hoch\/wp-content\/uploads\/sites\/725\/2020\/06\/SCE-green-768x563.jpg 768w, https:\/\/sites.usp.br\/hoch\/wp-content\/uploads\/sites\/725\/2020\/06\/SCE-green-80x60.jpg 80w, https:\/\/sites.usp.br\/hoch\/wp-content\/uploads\/sites\/725\/2020\/06\/SCE-green-400x293.jpg 400w\" sizes=\"(max-width: 604px) 100vw, 604px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\"> Fluorescence microscopy of a sister chromatid exchange assay. Chromosomes from a human cell are labelled such that one sister chromatid is seen in green and the other in blue. In response to DNA damage, homologous recombination may lead to the exchange of genetic information between sister chromatids, causing a reciprocal exchange in the colouring pattern of the chromosomes.\n<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-882a414\" data-id=\"882a414\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-574bcfc8 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"574bcfc8\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-41801b0c elementor-widget elementor-widget-text-editor\" data-id=\"41801b0c\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-size: 23px;\"> ADP-ribosila\u00e7\u00e3o \u00e9 uma modifica\u00e7\u00e3o p\u00f3s-traducional de prote\u00ednas com importante fun\u00e7\u00e3o na <\/span><span style=\"font-size: 23px;\">sinaliza\u00e7\u00e3o da presen\u00e7a de danos ao DNA, remodelamento da cromatina e recrutamento de fatores\u00a0<\/span><span style=\"font-size: 23px;\">de reparo de DNA para o local da les\u00e3o, al\u00e9m de um tipo de morte celular programada chamada\u00a0<\/span><span style=\"font-size: 23px;\">parthanatos. Mais recentemente, estamos interessados tamb\u00e9m em estudar a fun\u00e7\u00e3o da ADP-ribosila\u00e7\u00e3o de prote\u00ednas em outros contextos, em particular na resposta celular a infec\u00e7\u00f5es virais. <\/span><\/p><p><span style=\"font-size: 23px;\"><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-26c5925b elementor-widget elementor-widget-heading\" data-id=\"26c5925b\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-medium\"><a href=\"http:\/\/sites.usp.br\/hoch\/pesquisa\">saiba mais\n<\/a><\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-9ebe8cf elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"9ebe8cf\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-29ad1b4\" data-id=\"29ad1b4\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c997e02 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"c997e02\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-484ee40 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"484ee40\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-85e0686\" data-id=\"85e0686\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4d22f70 elementor-widget elementor-widget-heading\" data-id=\"4d22f70\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">CONTATE-NOS!\n<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-66fe5ce elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"66fe5ce\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-top-column elementor-element elementor-element-b83d3a8\" data-id=\"b83d3a8\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-0517dd0 elementor-widget elementor-widget-google_maps\" data-id=\"0517dd0\" data-element_type=\"widget\" data-widget_type=\"google_maps.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-custom-embed\">\n\t\t\t<iframe loading=\"lazy\"\n\t\t\t\t\tsrc=\"https:\/\/maps.google.com\/maps?q=Instituto%20de%20Qu%C3%ADmica%20da%20USP&#038;t=m&#038;z=14&#038;output=embed&#038;iwloc=near\"\n\t\t\t\t\ttitle=\"Instituto de Qu\u00edmica da USP\"\n\t\t\t\t\taria-label=\"Instituto de Qu\u00edmica da USP\"\n\t\t\t><\/iframe>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-top-column elementor-element elementor-element-7edbcf4\" data-id=\"7edbcf4\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-27df3ee elementor-view-stacked elementor-shape-circle elementor-widget elementor-widget-icon\" data-id=\"27df3ee\" data-element_type=\"widget\" data-widget_type=\"icon.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<div class=\"elementor-icon\">\n\t\t\t<i aria-hidden=\"true\" class=\"fas fa-location-arrow\"><\/i>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e32c423 elementor-widget elementor-widget-text-editor\" data-id=\"e32c423\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<pre class=\"widget-title\" style=\"text-align: center;\">Departamento de Bioqu\u00edmica - IQ\/USP<\/pre>\n<p class=\"widget-title\" style=\"text-align: center;\"><span style=\"letter-spacing: -0.3px;\">Av. Prof. Lineu Prestes, 748. S\u00e3o Paulo &#8211; SP &#8211; Brasil<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-top-column elementor-element elementor-element-7e36517\" data-id=\"7e36517\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-584c169 elementor-view-stacked elementor-shape-circle elementor-widget elementor-widget-icon\" data-id=\"584c169\" data-element_type=\"widget\" data-widget_type=\"icon.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<div class=\"elementor-icon\">\n\t\t\t<i aria-hidden=\"true\" class=\"fas fa-mail-bulk\"><\/i>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-31cbdc7 elementor-widget elementor-widget-text-editor\" data-id=\"31cbdc7\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<pre style=\"text-align: center;\"><span style=\"color: #555555; font-family: Roboto, RobotoDraft, Helvetica, Arial, sans-serif; font-size: 14px;\">nicolas@iq.usp.br<\/span><\/pre>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-top-column elementor-element elementor-element-6b2e9e8\" data-id=\"6b2e9e8\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5c8a59c elementor-view-stacked elementor-shape-circle elementor-widget elementor-widget-icon\" data-id=\"5c8a59c\" data-element_type=\"widget\" data-widget_type=\"icon.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<a class=\"elementor-icon\" href=\"https:\/\/www.instagram.com\/estabilidadegenomica\/\" target=\"_blank\">\n\t\t\t<i aria-hidden=\"true\" class=\"fab fa-instagram\"><\/i>\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d62673c elementor-widget elementor-widget-text-editor\" data-id=\"d62673c\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<pre style=\"text-align: center;\"><span style=\"color: #555555; font-family: Roboto, RobotoDraft, Helvetica, Arial, sans-serif;\"><span style=\"font-size: 14px;\"><a href=\"https:\/\/www.instagram.com\/estabilidadegenomica\/\">https:\/\/www.instagram.com\/estabilidadegenomica\/<\/a><\/span><\/span><\/pre>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>\u00a0We study how cells signal and repair lesions to our genetic material, the DNA. We are particularly\u00a0interested in how a post-translational modification called ADP-ribosylation accelerates DNA repair\u00a0processes, and how mutations in genes involved in DNA damage signalling and repair cause rare\u00a0genetic disorders characterized by neurodegeneration, cancer predisposition and premature aging. Fluorescence microscopy of human cells [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-79","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/sites.usp.br\/hoch\/en\/wp-json\/wp\/v2\/pages\/79","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.usp.br\/hoch\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.usp.br\/hoch\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.usp.br\/hoch\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.usp.br\/hoch\/en\/wp-json\/wp\/v2\/comments?post=79"}],"version-history":[{"count":4,"href":"https:\/\/sites.usp.br\/hoch\/en\/wp-json\/wp\/v2\/pages\/79\/revisions"}],"predecessor-version":[{"id":1066,"href":"https:\/\/sites.usp.br\/hoch\/en\/wp-json\/wp\/v2\/pages\/79\/revisions\/1066"}],"wp:attachment":[{"href":"https:\/\/sites.usp.br\/hoch\/en\/wp-json\/wp\/v2\/media?parent=79"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}