{"id":79,"date":"2014-02-24T16:51:20","date_gmt":"2014-02-24T18:51:20","guid":{"rendered":"http:\/\/sites.usp.br\/hoch\/?page_id=79"},"modified":"2024-08-02T17:25:16","modified_gmt":"2024-08-02T19:25:16","slug":"pagina-inicial","status":"publish","type":"page","link":"https:\/\/sites.usp.br\/hoch\/en\/","title":{"rendered":"Welcome to the Genomic Stability Lab website!"},"content":{"rendered":"<div data-elementor-type=\"wp-page\" data-elementor-id=\"79\" class=\"elementor elementor-79\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-7cd6d0d7 elementor-section-height-min-height elementor-section-content-middle elementor-section-boxed elementor-section-height-default elementor-section-items-middle\" data-id=\"7cd6d0d7\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-1b275c5b\" data-id=\"1b275c5b\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-60d379c3 elementor-widget elementor-widget-text-editor\" data-id=\"60d379c3\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><span style=\"font-size: 23px;\">\u00a0<span style=\"font-size: 23px;\">We study how cells signal and repair lesions to our genetic material, the DNA. We are particularly\u00a0<\/span><span style=\"font-size: 23px;\">interested in how a post-translational modification called <b>ADP-ribosylation<\/b> accelerates DNA repair\u00a0<\/span><span style=\"font-size: 23px;\">processes, and how mutations in genes involved in DNA damage signalling and repair cause rare\u00a0<\/span><span style=\"font-size: 23px;\">genetic disorders characterized by <b>neurodegeneration<\/b>, <b>cancer predisposition<\/b> and <b>premature aging<\/b>.<\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4f462c91 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"4f462c91\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-3b8b2c8c\" data-id=\"3b8b2c8c\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4fca368 elementor-widget elementor-widget-image\" data-id=\"4fca368\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"604\" height=\"451\" src=\"https:\/\/sites.usp.br\/hoch\/wp-content\/uploads\/sites\/725\/2020\/06\/LT-63x-Z1-deconv-1024x765.jpg\" class=\"attachment-large size-large wp-image-153\" alt=\"\" srcset=\"https:\/\/sites.usp.br\/hoch\/wp-content\/uploads\/sites\/725\/2020\/06\/LT-63x-Z1-deconv-1024x765.jpg 1024w, https:\/\/sites.usp.br\/hoch\/wp-content\/uploads\/sites\/725\/2020\/06\/LT-63x-Z1-deconv-300x224.jpg 300w, https:\/\/sites.usp.br\/hoch\/wp-content\/uploads\/sites\/725\/2020\/06\/LT-63x-Z1-deconv-768x574.jpg 768w, https:\/\/sites.usp.br\/hoch\/wp-content\/uploads\/sites\/725\/2020\/06\/LT-63x-Z1-deconv-80x60.jpg 80w, https:\/\/sites.usp.br\/hoch\/wp-content\/uploads\/sites\/725\/2020\/06\/LT-63x-Z1-deconv-400x299.jpg 400w, https:\/\/sites.usp.br\/hoch\/wp-content\/uploads\/sites\/725\/2020\/06\/LT-63x-Z1-deconv.jpg 1392w\" sizes=\"(max-width: 604px) 100vw, 604px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\"> Fluorescence microscopy of human cells in culture. Blue: DNA in the cell nucleus, green: actin filaments, red: mitochondria.<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-318d343b elementor-section-height-min-height elementor-section-content-middle elementor-reverse-mobile elementor-section-boxed elementor-section-height-default elementor-section-items-middle\" data-id=\"318d343b\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;none&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-86ff9eb\" data-id=\"86ff9eb\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8af89b2 elementor-widget elementor-widget-image\" data-id=\"8af89b2\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"604\" height=\"443\" src=\"https:\/\/sites.usp.br\/hoch\/wp-content\/uploads\/sites\/725\/2020\/06\/SCE-green.jpg\" class=\"attachment-large size-large wp-image-163\" alt=\"\" srcset=\"https:\/\/sites.usp.br\/hoch\/wp-content\/uploads\/sites\/725\/2020\/06\/SCE-green.jpg 1011w, https:\/\/sites.usp.br\/hoch\/wp-content\/uploads\/sites\/725\/2020\/06\/SCE-green-300x220.jpg 300w, https:\/\/sites.usp.br\/hoch\/wp-content\/uploads\/sites\/725\/2020\/06\/SCE-green-768x563.jpg 768w, https:\/\/sites.usp.br\/hoch\/wp-content\/uploads\/sites\/725\/2020\/06\/SCE-green-80x60.jpg 80w, https:\/\/sites.usp.br\/hoch\/wp-content\/uploads\/sites\/725\/2020\/06\/SCE-green-400x293.jpg 400w\" sizes=\"(max-width: 604px) 100vw, 604px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\"> Fluorescence microscopy of a sister chromatid exchange assay. Chromosomes from a human cell are labelled such that one sister chromatid is seen in green and the other in blue. In response to DNA damage, homologous recombination may lead to the exchange of genetic information between sister chromatids, causing a reciprocal exchange in the colouring pattern of the chromosomes.\n<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-882a414\" data-id=\"882a414\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-574bcfc8 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"574bcfc8\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-41801b0c elementor-widget elementor-widget-text-editor\" data-id=\"41801b0c\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><span style=\"font-size: 23px;\"> ADP-ribosylation is a post-translational modification of proteins with important roles in signaling the presence of DNA damage, in chromatin remodeling and recruitment of DNA repair factors to the damage site, as well as in a programmed cell death pathway called parthanatos. Recently we have also been interested in studying the role of ADP-ribosylation in other pathways, especially in the cellular response to viral infections. <\/span><span style=\"font-size: 23px;\">\u00a0<\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-26c5925b elementor-widget elementor-widget-heading\" data-id=\"26c5925b\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<p class=\"elementor-heading-title elementor-size-medium\"><a href=\"http:\/\/sites.usp.br\/hoch\/pesquisa\">learn more<\/a><\/p>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-9ebe8cf elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"9ebe8cf\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-29ad1b4\" data-id=\"29ad1b4\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c997e02 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"c997e02\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-484ee40 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"484ee40\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-85e0686\" data-id=\"85e0686\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4d22f70 elementor-widget elementor-widget-heading\" data-id=\"4d22f70\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\"> CONTACT US <\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-66fe5ce elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"66fe5ce\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-top-column elementor-element elementor-element-b83d3a8\" data-id=\"b83d3a8\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-0517dd0 elementor-widget elementor-widget-google_maps\" data-id=\"0517dd0\" data-element_type=\"widget\" data-widget_type=\"google_maps.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-custom-embed\">\n\t\t\t<iframe loading=\"lazy\"\n\t\t\t\t\tsrc=\"https:\/\/maps.google.com\/maps?q=Instituto%20de%20Qu%C3%ADmica%20da%20USP&#038;t=m&#038;z=14&#038;output=embed&#038;iwloc=near\"\n\t\t\t\t\ttitle=\"Instituto de Qu\u00edmica da USP\"\n\t\t\t\t\taria-label=\"Instituto de Qu\u00edmica da USP\"\n\t\t\t><\/iframe>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-top-column elementor-element elementor-element-7edbcf4\" data-id=\"7edbcf4\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-27df3ee elementor-view-stacked elementor-shape-circle elementor-widget elementor-widget-icon\" data-id=\"27df3ee\" data-element_type=\"widget\" data-widget_type=\"icon.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<div class=\"elementor-icon\">\n\t\t\t<i aria-hidden=\"true\" class=\"fas fa-location-arrow\"><\/i>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e32c423 elementor-widget elementor-widget-text-editor\" data-id=\"e32c423\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<pre class=\"widget-title\" style=\"text-align: center;\">Departamento de Bioqu\u00edmica - IQ\/USP<\/pre>\n<p class=\"widget-title\" style=\"text-align: center;\"><span style=\"letter-spacing: -0.3px;\">Av. Prof. Lineu Prestes, 748. S\u00e3o Paulo &#8211; SP &#8211; Brasil<\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-top-column elementor-element elementor-element-7e36517\" data-id=\"7e36517\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-584c169 elementor-view-stacked elementor-shape-circle elementor-widget elementor-widget-icon\" data-id=\"584c169\" data-element_type=\"widget\" data-widget_type=\"icon.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<div class=\"elementor-icon\">\n\t\t\t<i aria-hidden=\"true\" class=\"fas fa-mail-bulk\"><\/i>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-31cbdc7 elementor-widget elementor-widget-text-editor\" data-id=\"31cbdc7\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<pre style=\"text-align: center;\"><span style=\"color: #555555; font-family: Roboto, RobotoDraft, Helvetica, Arial, sans-serif; font-size: 14px;\">nicolas@iq.usp.br<\/span><\/pre>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-top-column elementor-element elementor-element-6b2e9e8\" data-id=\"6b2e9e8\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5c8a59c elementor-view-stacked elementor-shape-circle elementor-widget elementor-widget-icon\" data-id=\"5c8a59c\" data-element_type=\"widget\" data-widget_type=\"icon.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<a class=\"elementor-icon\" href=\"https:\/\/www.instagram.com\/estabilidadegenomica\/\" target=\"_blank\">\n\t\t\t<i aria-hidden=\"true\" class=\"fab fa-instagram\"><\/i>\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d62673c elementor-widget elementor-widget-text-editor\" data-id=\"d62673c\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<pre style=\"text-align: center;\"><span style=\"color: #555555; font-family: Roboto, RobotoDraft, Helvetica, Arial, sans-serif;\"><span style=\"font-size: 14px;\"><a href=\"https:\/\/www.instagram.com\/estabilidadegenomica\/\">https:\/\/www.instagram.com\/estabilidadegenomica\/<\/a><\/span><\/span><\/pre>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>\u00a0We study how cells signal and repair lesions to our genetic material, the DNA. We are particularly\u00a0interested in how a post-translational modification called ADP-ribosylation accelerates DNA repair\u00a0processes, and how mutations in genes involved in DNA damage signalling and repair cause rare\u00a0genetic disorders characterized by neurodegeneration, cancer predisposition and premature aging. Fluorescence microscopy of human cells [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-79","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/sites.usp.br\/hoch\/en\/wp-json\/wp\/v2\/pages\/79","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.usp.br\/hoch\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.usp.br\/hoch\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.usp.br\/hoch\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.usp.br\/hoch\/en\/wp-json\/wp\/v2\/comments?post=79"}],"version-history":[{"count":4,"href":"https:\/\/sites.usp.br\/hoch\/en\/wp-json\/wp\/v2\/pages\/79\/revisions"}],"predecessor-version":[{"id":1066,"href":"https:\/\/sites.usp.br\/hoch\/en\/wp-json\/wp\/v2\/pages\/79\/revisions\/1066"}],"wp:attachment":[{"href":"https:\/\/sites.usp.br\/hoch\/en\/wp-json\/wp\/v2\/media?parent=79"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}