{"id":216,"date":"2020-06-01T17:50:38","date_gmt":"2020-06-01T19:50:38","guid":{"rendered":"https:\/\/sites.usp.br\/hoch\/?page_id=216"},"modified":"2025-10-06T11:36:36","modified_gmt":"2025-10-06T13:36:36","slug":"publicacoes","status":"publish","type":"page","link":"https:\/\/sites.usp.br\/hoch\/en\/publicacoes\/","title":{"rendered":"Publications"},"content":{"rendered":"\t\t
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29. Ribeiro VC, Russo LC, Gonz\u00e1lez Dur\u00e9 DM, Hoch NC.<\/b>\u00a0Interferon-induced ADP-ribosylation: technical developments driving ICAB discovery. Biosci Rep.<\/strong> 31 March 2025; 45 (03): 197\u2013209. \u00a0DOI: 10.1042\/BSR20240986<\/a><\/u><\/b><\/p>

28.<\/b>\u00a0Moura RD de<\/b>, Mattos PD de<\/b>, Valente PF<\/b>, Hoch NC<\/b>. Molecular mechanisms of cell death by parthanatos: More questions than answers. Genet Mol Biol<\/b>. 2024;47:e20230357. DOI:10.1590\/1678-4685-GMB-2023-0357<\/a><\/u><\/b><\/p>

27.<\/strong>\u00a0Papp H, T\u00f3th E, B\u00f3v\u00e1ri-Biri J, B\u00e1nfai K, Juh\u00e1sz P, Mahdi M, Russo LC<\/b>, Bajusz D, Sipos A, Petri L, Szalai TV, Kem\u00e9ny \u00c1, Madai M, Kuczmog A, Batta G, M\u00f3zner O, Vask\u00f3 D, Hirsch E, Bohus P, M\u00e9hes G, T\u0151zs\u00e9r J, Curtin NJ, Helyes Z, T\u00f3th A, Hoch NC<\/b>, Jakab F, Keser\u0171 GM, Pongr\u00e1cz JE, Bai P. The PARP inhibitor rucaparib blocks SARS-CoV-2 virus binding to cells and the immune reaction in models of COVID-19. Br J Pharmacol<\/b>. 2024 Aug 27. DOI: 10.1111\/bph.17305<\/u><\/b><\/a>.<\/p>

26.<\/strong>\u00a0Latancia MT, Leandro GDS, Bastos AU, Moreno NC, Ariwoola AA, Martins DJ, Ashton NW, Ribeiro VC<\/b>, Hoch NC<\/b>, Rocha CRR, Woodgate R, Menck CFM. Human translesion DNA polymerases \u03b9 and \u03ba mediate tolerance to temozolomide in MGMT-deficient glioblastoma cells. DNA Repair (Amst)<\/b>. 2024 Jul 18;141:103715. DOI: 10.1016\/j.dnarep.2024.103715<\/u><\/b><\/a><\/p>

25.<\/strong>\u00a0Rijpkema KJ, Schuller M, van der Veer MS, Rieken S, Chang DLR, Bali\u0107 P, Todorov A, Minnee H, Wijngaarden S, Matos IA<\/b>, Hoch NC<\/b>, Cod\u00e9e JDC, Ahel I, Filippov DV. Synthesis of Structural ADP-Ribose Analogues as Inhibitors for SARS-CoV-2 Macrodomain 1. Org Lett<\/b>. 2024 Jul 12;26(27):5700-5704. DOI: 10.1021\/acs.orglett.4c01792<\/u><\/b><\/a><\/p>

24.<\/strong>\u00a0Ribeiro VC<\/b>, Russo LC<\/b>, Hoch NC<\/b>. PARP14 is regulated by the PARP9\/DTX3L complex and promotes interferon \u03b3-induced ADP-ribosylation. EMBO J<\/b>. 2024 Jul;43(14):2908-2928. DOI: 10.1038\/s44318-024-00125-1<\/u><\/b><\/a>
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23.<\/strong>\u00a0Matos IA<\/b>, Dallazen JL, Reis LR, Souza LF, Bevevino RC, de Moura RD<\/b>, Ronsein GE, Hoch NC<\/b>, da Costa J\u00fanior NB, Costa SKP, Meotti FC. Targeting Myeloperoxidase Ameliorates Gouty Arthritis: A Virtual Screening Success Story. J Med Chem.<\/b> 2024 Jul 25;67(14):12012-12032. DOI: 10.1021\/acs.jmedchem.4c00721<\/u><\/b><\/a>
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22.<\/strong>\u00a0Martins DJ, Di Lazzaro Filho R, Bertola DR, Hoch NC<\/b>. Rothmund-Thomson syndrome, a disorder far from solved. Front Aging.<\/b> 2023 Nov 10;4:1296409. DOI: 10.3389\/fragi.2023.1296409<\/u><\/b><\/a>
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21.<\/strong>\u00a0Di Lazzaro Filho R, Yamamoto GL, Silva TJ<\/b>, Rocha LA, Linnenkamp BDW, Castro MAA, Bartholdi D, Schaller A, Leeb T, Kelmann S, Utagawa CY, Steiner CE, Steinmetz L, Honjo RS, Kim CA, Wang L, Abourjaili-Bilodeau R, Campeau PM, Warman M, Passos-Bueno MR, Hoch NC<\/b>, Bertola DR. Biallelic variants in DNA2 cause poikiloderma with congenital cataracts and severe growth failure reminiscent of Rothmund-Thomson syndrome. J Med Genet.<\/b> 2023 Nov;60(11):1127-1132. DOI: 10.1136\/jmg-2022-109119<\/u><\/b><\/a>
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20.<\/strong> Serrano-Benitez A, Wells S, Drummond-Clarke L, Russo LC<\/strong>, Christopher Thomas J, Leal G<\/strong>, Farrow M, Edgerton JM, Balasubramanian S, Yang M, Frezza C, Gautam A, Brazina J, Burdova K, Hoch NC<\/strong>, Jackson SP, Caldecott KW. Unrepaired base excision repair intermediates in template DNA strands trigger replication fork collapse and PARP inhibitor sensitivity. The EMBO Journal<\/strong>. 2023 July 26. DOI: 10.15252\/embj.2022113190<\/a><\/span><\/strong><\/p>

19.<\/strong> Di Lazzaro Filho R, Yamamoto GL, Silva TJ<\/strong>, Rocha LA , Linnenkamp BDW , Castro MAA, Bartholdi D, Schaller A, Leeb T, Kelmann S, Utagawa CY, Steiner CE,\u00a0 Steinmetz L, Honjo RS, Kim CA, Wang L, Abourjaili-Bilodeau R, Campeau PM, Warman M, Passos-Bueno MR, Hoch NC<\/strong>, Bertola DR. Biallelic variants in DNA2 cause poikiloderma with congenital cataracts and severe growth failure reminiscent of Rothmund-Thomson syndrome. Journal of Medical Genetics<\/strong>. 2023 April 13. DOI: 10.1136\/jmg-2022-109119<\/strong><\/span><\/a><\/p>

18.<\/strong> Latancia MT, Moreno NC, Leandro GS, Ribeiro VC<\/strong>, Souza I, Vieira WKM, Bastos AU, Hoch NC<\/strong>, Rocha CRR, Menck CFM. DNA polymerase eta protects human cells against DNA damage induced by the tumor chemotherapeutic temozolomide. Mutation Research – Genetic Toxicology and Environmental Mutagenesis<\/strong>. 2022 May 5. DOI: 10.1016\/j.mrgentox.2022.503498<\/strong><\/span><\/a><\/p>

17.<\/strong> Hoch NC<\/strong>. Host ADP-ribosylation and the SARS-CoV-2 macrodomain. Biochem Soc Trans<\/strong>. 2021 Aug 27;49(4):1711-1721. DOI: 10.1042\/BST20201212<\/span><\/strong><\/a><\/p>

16.<\/strong>\u00a0Russo LC<\/b>, Tomasin R, Matos IA<\/b>, Manucci AC, Sowa ST, Dale K, Caldecott KW, Lehti\u00f6 L, Schechtman D, Meotti FC, Bruni-Cardoso A,\u00a0Hoch NC<\/strong>. The SARS-CoV-2 Nsp3 macrodomain reverses PARP9\/DTX3L-dependent ADP-ribosylation induced by interferon signalling.\u00a0J Biol Chem<\/strong>. 2021 Aug 3;297(3):101041. DOI: 10.1016\/j.jbc.2021.101041<\/span><\/strong><\/a><\/p>

15.<\/strong>\u00a0L\u00fcscher B, Ahel I, Altmeyer M, Ashworth A, Bai P, Chang P, Cohen M, Corda D, Dantzer F, Daugherty MD, Dawson TM, Dawson VL, Deindl S, Fehr AR, Feijs KLH, Filippov DV, Gagn\u00e9 JP, Grimaldi G, Guettler S,\u00a0Hoch NC<\/strong>, Hottiger MO, Korn P, Kraus WL, Ladurner A, Lehti\u00f6 L, Leung AKL, Lord CJ, Mangerich A, Matic I, Matthews J, Moldovan GL, Moss J, Natoli G, Nielsen ML, Niepel M, Nolte F, Pascal J, Paschal BM, Paw\u0142owski K, Poirier GG, Smith S, Timinszky G, Wang ZQ, Y\u00e9lamos J, Yu X, Zaja R, Ziegler M. ADP-ribosyltransferases, an update on function and nomenclature.\u00a0FEBS J<\/strong>. 2021 Jul 29. DOI: 10.1111\/febs.16142<\/span><\/strong><\/a><\/p>

14.<\/strong> King A, Hoch NC<\/strong>, McGregor NE, Sims NA, Smyth IM, and Heierhorst J (2019). Dynll1 is essential for development and promotes endochondral bone formation by regulating intraflagellar Dynein function in primary cilia. Hum Mol Genet<\/strong>: ddz083. DOI: 10.1093\/hmg\/ddz083<\/strong><\/span><\/a><\/p>

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13.<\/strong> Hoch NC<\/strong> and Polo LM (2019). ADP-ribosylation: from molecular mechanisms to human disease. <\/span>Genet Mol Biol<\/strong>. 43(1 suppl 1), e20190075. <\/span>DOI<\/strong>: 10.1590\/1678-4685-gmb-2019-0075<\/strong><\/span><\/span><\/a><\/p>

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12.<\/strong> Baptista MS, Alves MJM, Arantes GM, Armelin HA, Augusto O, Baldini RL, Basseres DS, Bechara EJH, Bruni-Cardoso A, Chaimovich H, Colepicolo Neto P, Colli W, Cuccovia IM, Da-Silva AM, Di Mascio P, Farah SC, Ferreira C, Forti FL, Giordano RJ, Gomes SL, Gueiros Filho FJ, <\/span>Hoch NC<\/strong>, Hotta CT, Labriola L, Lameu C, Machini MT, Malnic B, Marana SR, Medeiros MHG, Meotti FC, Miyamoto S, Oliveira CC, Souza-Pinto NC, Reis EM, Ronsein GE, Salinas RK, Schechtman D, Schreier S, Setubal JC, Sogayar MC, Souza GM, Terra WR, Truzzi DR, Ulrich H, Verjovski-Almeida S, Winck FV, Zingales B, and Kowaltowski AJ (2019). Where do we aspire to publish? A position paper on scientific communication in biochemistry and molecular biology. <\/span>Braz J Med Biol Res<\/strong>. 52(9): e8935. <\/span>DOI: 10.1590\/1414-431×20198935<\/span><\/strong><\/span><\/a><\/p>

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11.<\/strong> Liu R, King A, <\/span>Hoch NC<\/strong>, Chang C, Kelly GL, Deans AJ, and Heierhorst J (2017). ASCIZ\/ATMIN is dispensable for ATM signaling in response to replication stress. <\/span>DNA Repair<\/strong> (Amst). 57: 29-34. <\/span>DOI: 10.1016\/j.dnarep.2017.06.022<\/span><\/strong><\/span><\/a><\/p>

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10.<\/strong> Hoch NC<\/strong>, Hanzlikova H, Rulten SL, Tetreault M, Komulainen E, Ju L, Hornyak P, Zeng Z, Gittens W, Rey SA, Staras K, Mancini GM, McKinnon PJ, Wang ZQ, Wagner JD, Yoon G, and Caldecott KW (2017). XRCC1 mutation is associated with PARP1 hyperactivation and cerebellar ataxia. <\/span>Nature<\/strong>. 541(7635): 87-91. <\/span>DOI: 10.1038\/nature20790<\/span><\/strong><\/span><\/a><\/p>

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9.<\/strong> Hoch NC<\/strong>, Chen ES, Tsai MD, and Heierhorst J (2017). Quantitative Analysis of Yeast Checkpoint Protein Kinase Activity by Combined Mass Spectrometry Enzyme Assays. <\/span>Methods Enzymol<\/strong>. 586: 143-164. <\/span>DOI: 10.1016\/bs.mie.2016.09.032<\/span><\/strong><\/span><\/a><\/p>

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8.<\/strong> Breslin C, Mani RS, Fanta M, <\/span>Hoch N<\/strong>, Weinfeld M, and Caldecott KW (2017). The Rev1 interacting region (RIR) motif in the scaffold protein XRCC1 mediates a low-affinity interaction with polynucleotide kinase\/phosphatase (PNKP) during DNA single-strand break repair. <\/span>J Biol Chem<\/strong>. 292(39): 16024-16031. <\/span>DOI: 10.1074\/jbc.M117.806638<\/span><\/strong><\/span><\/a><\/p>

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7.<\/strong> Grundy GJ, Polo LM, Zeng Z, Rulten SL, <\/span>Hoch NC<\/strong>, Paomephan P, Xu Y, Sweet SM, Thorne AW, Oliver AW, Matthews SJ, Pearl LH, and Caldecott KW (2016). PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2B(Glu2). <\/span>Nat Commun<\/strong>. 7: 12404. <\/span>DOI: 10.1038\/ncomms12404<\/span><\/strong><\/span><\/a><\/p>

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6.<\/strong> Hoch NC<\/strong>, Lai X, and Heierhorst J (2013). Genomic stability disorders: from budding yeast to humans. <\/span>Front Biosci<\/strong> (Schol Ed). 5: 396-411. <\/span>DOI: 10.2741\/s379<\/span><\/strong><\/span><\/a><\/p>

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5.<\/strong> Hoch NC<\/strong>, Chen ES, Buckland R, Wang SC, Fazio A, Hammet A, Pellicioli A, Chabes A, Tsai MD, and Heierhorst J (2013). Molecular basis of the essential s phase function of the rad53 checkpoint kinase. <\/span>Mol Cell Biol<\/strong>. 33(16): 3202-13.\u00a0<\/span>DOI: 10.1128\/MCB.00474-13<\/u><\/b><\/a><\/p>

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4.<\/strong> Chen ES, <\/span>Hoch NC<\/strong>, Wang SC, Pellicioli A, Heierhorst J, and Tsai MD (2013). Use of quantitative mass spectrometric analysis to elucidate the mechanisms of phospho-priming and auto-activation of the checkpoint kinase Rad53 <\/span>in vivo<\/em>. <\/span>Mol Cell Proteomics<\/strong>. <\/span>DOI: 10.1074\/mcp.M113.034058<\/span><\/strong><\/span><\/a><\/p>

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3.<\/strong> Jurado S, Conlan LA, Baker EK, Ng JL, Tenis N, <\/span>Hoch NC<\/strong>, Gleeson K, Smeets M, Izon D, and Heierhorst J (2012). ATM substrate Chk2-interacting Zn2+ finger (ASCIZ) Is a bi-functional transcriptional activator and feedback sensor in the regulation of dynein light chain (DYNLL1) expression. <\/span>J Biol Chem<\/strong>. 287(5): 3156-64. <\/span>DOI: 10.1074\/jbc.M111.306019<\/span><\/strong><\/span><\/a><\/p>

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2.<\/strong> Hoch NC<\/strong>, Santos RS, Rosa RM, Machado RM, Saffi J, Brendel M, and Henriques JA (2008). Allelism of Saccharomyces cerevisiae gene PSO10, involved in error-prone repair of psoralen-induced DNA damage, with SUMO ligase-encoding MMS21. <\/span>Curr Genet<\/strong>. 53(6): 361-71. <\/span>DOI: 10.1007\/s00294-008-0192-z<\/span><\/strong><\/span><\/a><\/p>

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1.<\/strong> Rosa RM, <\/span>Hoch NC<\/strong>, Furtado GV, Saffi J, and Henriques JA (2007). DNA damage in tissues and organs of mice treated with diphenyl diselenide. <\/span>Mutat Res<\/strong>. 633(1): 35-45. <\/span>DOI: 10.1016\/j.mrgentox.2007.05.006<\/span><\/strong><\/span><\/a><\/p>

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29. Ribeiro VC, Russo LC, Gonz\u00e1lez Dur\u00e9 DM, Hoch NC.\u00a0Interferon-induced ADP-ribosylation: technical developments driving ICAB discovery. Biosci Rep. 31 March 2025; 45 (03): 197\u2013209. \u00a0DOI: 10.1042\/BSR20240986 28.\u00a0Moura RD de, Mattos PD de, Valente PF, Hoch NC. Molecular mechanisms of cell death by parthanatos: More questions than answers. Genet Mol Biol. 2024;47:e20230357. DOI:10.1590\/1678-4685-GMB-2023-0357 27.\u00a0Papp H, T\u00f3th […]<\/p>\n","protected":false},"author":1200,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-216","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/sites.usp.br\/hoch\/en\/wp-json\/wp\/v2\/pages\/216","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.usp.br\/hoch\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.usp.br\/hoch\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.usp.br\/hoch\/en\/wp-json\/wp\/v2\/users\/1200"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.usp.br\/hoch\/en\/wp-json\/wp\/v2\/comments?post=216"}],"version-history":[{"count":4,"href":"https:\/\/sites.usp.br\/hoch\/en\/wp-json\/wp\/v2\/pages\/216\/revisions"}],"predecessor-version":[{"id":1183,"href":"https:\/\/sites.usp.br\/hoch\/en\/wp-json\/wp\/v2\/pages\/216\/revisions\/1183"}],"wp:attachment":[{"href":"https:\/\/sites.usp.br\/hoch\/en\/wp-json\/wp\/v2\/media?parent=216"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}