{"id":79,"date":"2014-02-24T16:51:20","date_gmt":"2014-02-24T18:51:20","guid":{"rendered":"http:\/\/sites.usp.br\/hoch\/?page_id=79"},"modified":"2024-08-02T17:25:16","modified_gmt":"2024-08-02T19:25:16","slug":"pagina-inicial","status":"publish","type":"page","link":"https:\/\/sites.usp.br\/hoch\/","title":{"rendered":"Bem-vindo ao site do Laborat\u00f3rio de Estabilidade Gen\u00f4mica!"},"content":{"rendered":"<div data-elementor-type=\"wp-page\" data-elementor-id=\"79\" class=\"elementor elementor-79\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-7cd6d0d7 elementor-section-height-min-height elementor-section-content-middle elementor-section-boxed elementor-section-height-default elementor-section-items-middle\" data-id=\"7cd6d0d7\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-1b275c5b\" data-id=\"1b275c5b\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-60d379c3 elementor-widget elementor-widget-text-editor\" data-id=\"60d379c3\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><span style=\"font-size: 23px;\">N\u00f3s estudamos como c\u00e9lulas sinalizam e reparam danos ao nosso material gen\u00e9tico, o DNA. Em <\/span><span style=\"font-size: 23px;\">especial, temos interesse em como uma modifica\u00e7\u00e3o p\u00f3s-traducional chamada <b>ADP-ribosila\u00e7\u00e3o<\/b>\u00a0<\/span><span style=\"font-size: 23px;\">acelera os processos de reparo, e em como muta\u00e7\u00f5es em genes envolvidos na sinaliza\u00e7\u00e3o e reparo\u00a0<\/span><span style=\"font-size: 23px;\">de DNA causam doen\u00e7as gen\u00e9ticas raras caracterizadas por <b>neurodegenera\u00e7\u00e3o<\/b>, <b>predisposi\u00e7\u00e3o ao\u00a0<\/b><\/span><span style=\"font-size: 23px;\"><b>c\u00e2ncer<\/b> e <b>envelhecimento precoce<\/b>.<\/span><\/p><p><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4f462c91 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"4f462c91\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-3b8b2c8c\" data-id=\"3b8b2c8c\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4fca368 elementor-widget elementor-widget-image\" data-id=\"4fca368\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"604\" height=\"451\" src=\"https:\/\/sites.usp.br\/hoch\/wp-content\/uploads\/sites\/725\/2020\/06\/LT-63x-Z1-deconv-1024x765.jpg\" class=\"attachment-large size-large wp-image-153\" alt=\"\" srcset=\"https:\/\/sites.usp.br\/hoch\/wp-content\/uploads\/sites\/725\/2020\/06\/LT-63x-Z1-deconv-1024x765.jpg 1024w, https:\/\/sites.usp.br\/hoch\/wp-content\/uploads\/sites\/725\/2020\/06\/LT-63x-Z1-deconv-300x224.jpg 300w, https:\/\/sites.usp.br\/hoch\/wp-content\/uploads\/sites\/725\/2020\/06\/LT-63x-Z1-deconv-768x574.jpg 768w, https:\/\/sites.usp.br\/hoch\/wp-content\/uploads\/sites\/725\/2020\/06\/LT-63x-Z1-deconv-80x60.jpg 80w, https:\/\/sites.usp.br\/hoch\/wp-content\/uploads\/sites\/725\/2020\/06\/LT-63x-Z1-deconv-400x299.jpg 400w, https:\/\/sites.usp.br\/hoch\/wp-content\/uploads\/sites\/725\/2020\/06\/LT-63x-Z1-deconv.jpg 1392w\" sizes=\"(max-width: 604px) 100vw, 604px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\"> Microscopia de fluoresc\u00eancia de c\u00e9lulas humanas em cultura. Azul: DNA no n\u00facleo da c\u00e9lulas, verde: filamentos de actina, vermelho: mitoc\u00f4ndrias. <\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-318d343b elementor-section-height-min-height elementor-section-content-middle elementor-reverse-mobile elementor-section-boxed elementor-section-height-default elementor-section-items-middle\" data-id=\"318d343b\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;none&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-86ff9eb\" data-id=\"86ff9eb\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8af89b2 elementor-widget elementor-widget-image\" data-id=\"8af89b2\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"604\" height=\"443\" src=\"https:\/\/sites.usp.br\/hoch\/wp-content\/uploads\/sites\/725\/2020\/06\/SCE-green.jpg\" class=\"attachment-large size-large wp-image-163\" alt=\"\" srcset=\"https:\/\/sites.usp.br\/hoch\/wp-content\/uploads\/sites\/725\/2020\/06\/SCE-green.jpg 1011w, https:\/\/sites.usp.br\/hoch\/wp-content\/uploads\/sites\/725\/2020\/06\/SCE-green-300x220.jpg 300w, https:\/\/sites.usp.br\/hoch\/wp-content\/uploads\/sites\/725\/2020\/06\/SCE-green-768x563.jpg 768w, https:\/\/sites.usp.br\/hoch\/wp-content\/uploads\/sites\/725\/2020\/06\/SCE-green-80x60.jpg 80w, https:\/\/sites.usp.br\/hoch\/wp-content\/uploads\/sites\/725\/2020\/06\/SCE-green-400x293.jpg 400w\" sizes=\"(max-width: 604px) 100vw, 604px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\"> Microscopia de fluoresc\u00eancia de um ensaio de sister chromatid exchanges. Cromossomos de uma c\u00e9lula humanas est\u00e3o marcados de forma que uma crom\u00e1tide irm\u00e3 seja visualizada em verde e a outra em azul. Em resposta a danos ao DNA, pode haver troca de informa\u00e7\u00e3o gen\u00e9tica entre as crom\u00e1tides-irm\u00e3s pela via de recombina\u00e7\u00e3o hom\u00f3loga, levando a trocas rec\u00edprocas no padr\u00e3o de colora\u00e7\u00e3o dos cromossomos.\n<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-882a414\" data-id=\"882a414\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-574bcfc8 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"574bcfc8\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-41801b0c elementor-widget elementor-widget-text-editor\" data-id=\"41801b0c\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><span style=\"font-size: 23px;\"> ADP-ribosila\u00e7\u00e3o \u00e9 uma modifica\u00e7\u00e3o p\u00f3s-traducional de prote\u00ednas com importante fun\u00e7\u00e3o na <\/span><span style=\"font-size: 23px;\">sinaliza\u00e7\u00e3o da presen\u00e7a de danos ao DNA, remodelamento da cromatina e recrutamento de fatores\u00a0<\/span><span style=\"font-size: 23px;\">de reparo de DNA para o local da les\u00e3o, al\u00e9m de um tipo de morte celular programada chamada\u00a0<\/span><span style=\"font-size: 23px;\">parthanatos. Mais recentemente, estamos interessados tamb\u00e9m em estudar a fun\u00e7\u00e3o da ADP-ribosila\u00e7\u00e3o de prote\u00ednas em outros contextos, em particular na resposta celular a infec\u00e7\u00f5es virais. <\/span><\/p><p><span style=\"font-size: 23px;\"><\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-26c5925b elementor-widget elementor-widget-heading\" data-id=\"26c5925b\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<p class=\"elementor-heading-title elementor-size-medium\"><a href=\"http:\/\/sites.usp.br\/hoch\/pesquisa\">saiba mais\n<\/a><\/p>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-9ebe8cf elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"9ebe8cf\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-29ad1b4\" data-id=\"29ad1b4\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c997e02 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"c997e02\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-484ee40 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"484ee40\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-85e0686\" data-id=\"85e0686\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4d22f70 elementor-widget elementor-widget-heading\" data-id=\"4d22f70\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">CONTATE-NOS!\n<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-66fe5ce elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"66fe5ce\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-top-column elementor-element elementor-element-b83d3a8\" data-id=\"b83d3a8\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-0517dd0 elementor-widget elementor-widget-google_maps\" data-id=\"0517dd0\" data-element_type=\"widget\" data-widget_type=\"google_maps.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-custom-embed\">\n\t\t\t<iframe loading=\"lazy\"\n\t\t\t\t\tsrc=\"https:\/\/maps.google.com\/maps?q=Instituto%20de%20Qu%C3%ADmica%20da%20USP&#038;t=m&#038;z=14&#038;output=embed&#038;iwloc=near\"\n\t\t\t\t\ttitle=\"Instituto de Qu\u00edmica da USP\"\n\t\t\t\t\taria-label=\"Instituto de Qu\u00edmica da USP\"\n\t\t\t><\/iframe>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-top-column elementor-element elementor-element-7edbcf4\" data-id=\"7edbcf4\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-27df3ee elementor-view-stacked elementor-shape-circle elementor-widget elementor-widget-icon\" data-id=\"27df3ee\" data-element_type=\"widget\" data-widget_type=\"icon.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<div class=\"elementor-icon\">\n\t\t\t<i aria-hidden=\"true\" class=\"fas fa-location-arrow\"><\/i>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e32c423 elementor-widget elementor-widget-text-editor\" data-id=\"e32c423\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<pre class=\"widget-title\" style=\"text-align: center;\">Departamento de Bioqu\u00edmica - IQ\/USP<\/pre>\n<p class=\"widget-title\" style=\"text-align: center;\"><span style=\"letter-spacing: -0.3px;\">Av. Prof. Lineu Prestes, 748. S\u00e3o Paulo &#8211; SP &#8211; Brasil<\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-top-column elementor-element elementor-element-7e36517\" data-id=\"7e36517\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-584c169 elementor-view-stacked elementor-shape-circle elementor-widget elementor-widget-icon\" data-id=\"584c169\" data-element_type=\"widget\" data-widget_type=\"icon.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<div class=\"elementor-icon\">\n\t\t\t<i aria-hidden=\"true\" class=\"fas fa-mail-bulk\"><\/i>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-31cbdc7 elementor-widget elementor-widget-text-editor\" data-id=\"31cbdc7\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<pre style=\"text-align: center;\"><span style=\"color: #555555; font-family: Roboto, RobotoDraft, Helvetica, Arial, sans-serif; font-size: 14px;\">nicolas@iq.usp.br<\/span><\/pre>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-top-column elementor-element elementor-element-6b2e9e8\" data-id=\"6b2e9e8\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5c8a59c elementor-view-stacked elementor-shape-circle elementor-widget elementor-widget-icon\" data-id=\"5c8a59c\" data-element_type=\"widget\" data-widget_type=\"icon.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<a class=\"elementor-icon\" href=\"https:\/\/www.instagram.com\/estabilidadegenomica\/\" target=\"_blank\">\n\t\t\t<i aria-hidden=\"true\" class=\"fab fa-instagram\"><\/i>\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d62673c elementor-widget elementor-widget-text-editor\" data-id=\"d62673c\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<pre style=\"text-align: center;\"><span style=\"color: #555555; font-family: Roboto, RobotoDraft, Helvetica, Arial, sans-serif;\"><span style=\"font-size: 14px;\"><a href=\"https:\/\/www.instagram.com\/estabilidadegenomica\/\">https:\/\/www.instagram.com\/estabilidadegenomica\/<\/a><\/span><\/span><\/pre>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>N\u00f3s estudamos como c\u00e9lulas sinalizam e reparam danos ao nosso material gen\u00e9tico, o DNA. Em especial, temos interesse em como uma modifica\u00e7\u00e3o p\u00f3s-traducional chamada ADP-ribosila\u00e7\u00e3o\u00a0acelera os processos de reparo, e em como muta\u00e7\u00f5es em genes envolvidos na sinaliza\u00e7\u00e3o e reparo\u00a0de DNA causam doen\u00e7as gen\u00e9ticas raras caracterizadas por neurodegenera\u00e7\u00e3o, predisposi\u00e7\u00e3o ao\u00a0c\u00e2ncer e envelhecimento precoce. Microscopia de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-79","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/sites.usp.br\/hoch\/wp-json\/wp\/v2\/pages\/79","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.usp.br\/hoch\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.usp.br\/hoch\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.usp.br\/hoch\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.usp.br\/hoch\/wp-json\/wp\/v2\/comments?post=79"}],"version-history":[{"count":4,"href":"https:\/\/sites.usp.br\/hoch\/wp-json\/wp\/v2\/pages\/79\/revisions"}],"predecessor-version":[{"id":1066,"href":"https:\/\/sites.usp.br\/hoch\/wp-json\/wp\/v2\/pages\/79\/revisions\/1066"}],"wp:attachment":[{"href":"https:\/\/sites.usp.br\/hoch\/wp-json\/wp\/v2\/media?parent=79"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}