{"id":387,"date":"2024-01-27T16:29:03","date_gmt":"2024-01-27T18:29:03","guid":{"rendered":"https:\/\/sites.usp.br\/labfisiorenal\/?page_id=387"},"modified":"2024-02-01T10:09:03","modified_gmt":"2024-02-01T12:09:03","slug":"linhas","status":"publish","type":"page","link":"https:\/\/sites.usp.br\/labfisiorenal\/linhas\/","title":{"rendered":"Linhas"},"content":{"rendered":"
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    \"\"<\/a><\/p>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<\/li>\n\t\t<\/ul>\t\t\t\t

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    1. <\/a><\/li>\n\t\t\t\t\t\t\t\t\t<\/ol>\n\n\t\t\t\t
      \n\t\t\t\t\t\n\t\t\t\t\t\t<\/em>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\n\t\t\t\t
      \n\t\t\t\t\t\n\t\t\t\t\t\t<\/em>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div><\/div><\/div><\/div><\/div><\/div>
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      Implica\u00e7\u00f5es da sinaliza\u00e7\u00e3o apelin\u00e9rgica sobre o transporte renal de s\u00f3dio e \u00e1gua: papel da isquemia\/reperfus\u00e3o.<\/span><\/h2>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div>
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      Objetivo:<\/span><\/h4>\n

      Investigar os efeitos da via de sinaliza\u00e7\u00e3o ativada por apelina-13 sobre<\/strong>
      \nas prote\u00ednas transportadoras de s\u00f3dio ao longo do n\u00e9fron, utilizando camundongos<\/strong>
      \nda linhagem C57BL\/6 e diferentes linhagens de c\u00e9lulas tubulares. Nesse contexto,<\/strong>
      \nainda ser\u00e1 analisada a via de reabsor\u00e7\u00e3o distal de \u00e1gua por AQP2.<\/strong><\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div>

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      Nefropatia cristalina em camundongos: papel da prote\u00edna Tamm-Horsfall<\/em> (THP) na les\u00e3o renal aguda e sua progress\u00e3o para doen\u00e7a renal cr\u00f4nica.<\/span><\/h2>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div>
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      Objetivo:<\/span><\/h4>\n

      Investigar a fun\u00e7\u00e3o da THP na les\u00e3o renal aguda, na progress\u00e3o desta<\/strong>
      \npara doen\u00e7a renal cr\u00f4nica e na recidiva, induzidas por nefropatia cristalina. Para<\/strong>
      \ntal, ser\u00e3o utilizados modelos in vivo e in vitro.<\/strong><\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div>

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      Estudo da vulnerabilidade do rim remanescente em decorr\u00eancia de nefrectomia unilateral, quando submetido \u00e0 nefropatia cristalina.<\/span><\/h2>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div>
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      \n\t

      Objetivo:<\/span><\/h4>\n

      Investigar a fun\u00e7\u00e3o do rim remanescente ap\u00f3s a nefrectomia unilateral<\/strong>
      \nassociada ou n\u00e3o \u00e0 nefropatia cristalina, bem como os poss\u00edveis fatores e<\/strong>
      \nmecanismos envolvidos na vulnerabilidade para a progress\u00e3o de doen\u00e7a renal,<\/strong>
      \nassociados ou n\u00e3o \u00e0 a\u00e7\u00e3o da metaloproteinase 10.<\/strong><\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div>

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      Participa\u00e7\u00e3o da via de sinaliza\u00e7\u00e3o MAPK e do fator de transcri\u00e7\u00e3o Egr-1 na glomeruloesclerose.<\/span><\/h2>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div>
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      Objetivo:<\/span><\/h4>\n

      Avaliar a contribui\u00e7\u00e3o da via de sinaliza\u00e7\u00e3o MAPK (ERK 1\/2 e<\/strong>
      \np38MAPK) na ativa\u00e7\u00e3o do fator de transcri\u00e7\u00e3o Egr-1 e respostas fibr\u00f3ticas no<\/strong>
      \ncontexto da glomeruloesclerose<\/strong>.<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div>

      \n
      \n\t

      Mecanismos de sinaliza\u00e7\u00e3o celular para respostas fibr\u00f3ticas comparando machos e f\u00eameas em modelo experimental de cisplatina.<\/span><\/h2>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div>
      \n
      \n\t

      Objetivo:<\/span><\/h4>\n

      Apontar os fatores respons\u00e1veis pela fibrose renal induzida por<\/strong>
      \ncisplatina em modelo in vivo (camundongos BALBc machos e f\u00eameas) e in vitro<\/strong>
      \n(c\u00e9lulas tubulares tratadas com cisplatina).<\/strong><\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div>

      \n
      \n\t

      Participa\u00e7\u00e3o da via ERK\/p38MAPK no reparo ou apoptose de c\u00e9lulas do t\u00fabulo proximal ap\u00f3s o insulto de isquemia e reperfus\u00e3o.<\/span><\/h2>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div>
      \n
      \n\t

      Objetivo:<\/span><\/h4>\n

      Avaliar a contribui\u00e7\u00e3o da via ERK1\/2\/P38MAPK no reparo ou apoptose<\/strong>
      \nde c\u00e9lulas do t\u00fabulo proximal ap\u00f3s o insulto de isquemia e reperfus\u00e3o.<\/strong><\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"

      Implica\u00e7\u00f5es da sinaliza\u00e7\u00e3o apelin\u00e9rgica sobre o transporte renal de s\u00f3dio e \u00e1gua: papel da isquemia\/reperfus\u00e3o.<\/p>\n","protected":false},"author":23908,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-387","page","type-page","status-publish","hentry"],"yoast_head":"\nLinhas - Laborat\u00f3rio de Fisiologia Renal<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sites.usp.br\/labfisiorenal\/linhas\/\" \/>\n<meta name=\"twitter:label1\" content=\"Est. tempo de leitura\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/sites.usp.br\\\/labfisiorenal\\\/linhas\\\/\",\"url\":\"https:\\\/\\\/sites.usp.br\\\/labfisiorenal\\\/linhas\\\/\",\"name\":\"Linhas - 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