{"id":396,"date":"2021-08-14T14:28:47","date_gmt":"2021-08-14T16:28:47","guid":{"rendered":"https:\/\/sites.usp.br\/labvasc_icb\/?page_id=396"},"modified":"2021-11-23T15:05:50","modified_gmt":"2021-11-23T17:05:50","slug":"linhas-de-pesquisa","status":"publish","type":"page","link":"https:\/\/sites.usp.br\/labvasc_icb\/linhas-de-pesquisa\/","title":{"rendered":"Linhas de Pesquisa e Financiamento"},"content":{"rendered":"\t\t
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\n\t\t\t\t\n\t\t\t\t\tFinanciamento<\/span>\n\t\t\t\t<\/span>\n\t\t\t\t<\/h3>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\tConhe\u00e7a os projetos associados ao Laborat\u00f3rio de Fisiologia Vascular\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t
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\n\t\t\t\t\t\t\tAcesse a p\u00e1gina da chefe do Laborat\u00f3rio de Fisiologia Cardiovascular na Biblioteca Virtual da FAPESP\t\t\t\t\t\t<\/h3>\n\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\tClique Aqui\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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Os projetos do Laborat\u00f3rio de Fisiologia Vascular possuem apoio das ag\u00eancias de fomento FAPESP<\/a> (Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo), CNPq<\/a> (Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico) e CAPES (Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior)<\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\t\n\t\t\t\t\tLinhas de Pesquisa<\/span>\n\t\t\t\t<\/span>\n\t\t\t\t<\/h3>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Fisiopatologia do Sistema Vascular<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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O sistema cardiovascular possui a fun\u00e7\u00e3o primordial de gerar fluxo adequado para os \u00f3rg\u00e3os e tecidos do nosso organismo. Nessa dire\u00e7\u00e3o, os vasos sangu\u00edneos, por meio de ajustes ativos (t\u00f4nus vascular) e passivos (remodelamento estrutural e mec\u00e2nico), s\u00e3o de fundamental import\u00e2ncia para a manuten\u00e7\u00e3o e distribui\u00e7\u00e3o desse fluxo sangu\u00edneo e para o controle da resist\u00eancia vascular perif\u00e9rica e do retorno venoso. Dentre os mecanismos que controlam o t\u00f4nus e o remodelamento vascular podemos citar: as for\u00e7as hemodin\u00e2micas e os mecanismos locais, hormonais e neurais. Sabe-se que as doen\u00e7as que acometem o sistema cardiovascular possuem alta preval\u00eancia na popula\u00e7\u00e3o, sendo comumente doen\u00e7as cr\u00f4nicas que oneram os cofres p\u00fablicos, e apesar dos avan\u00e7os no diagn\u00f3stico e tratamento, ainda possuem altas taxas de mortalidade e reduzem a qualidade de vida dos pacientes.\u00a0<\/p>

No Laborat\u00f3rio de Fisiologia Vascular (LabVasc) buscamos elucidar as vias de sinaliza\u00e7\u00e3o celular e as bases moleculares envolvidas nos ajustes funcionais (reatividade vascular) e estruturais (remodelamento estrutural e mec\u00e2nico) em vasos de condut\u00e2ncia e resist\u00eancia em doen\u00e7as cardiovasculares (hipertens\u00e3o arterial e insufici\u00eancia card\u00edaca), assim como em manobras farmacol\u00f3gicas e n\u00e3o farmacol\u00f3gicas (exerc\u00edcio f\u00edsico, microbiota e amamenta\u00e7\u00e3o cruzada) que podem restaurar ou prevenir as les\u00f5es vasculares.\u00a0<\/p>

Nossos estudos s\u00e3o focados na avalia\u00e7\u00e3o da participa\u00e7\u00e3o do endot\u00e9lio, do tecido adiposo perivascular (PVAT), da inerva\u00e7\u00e3o perivascular e da Na+, K+-ATPase (por meio da a\u00e7\u00e3o ouaba\u00edna na via signalosome) nos ajustes vasculares. Para tal, s\u00e3o realizadas avalia\u00e7\u00f5es hemodin\u00e2micas (arteriais e ventriculares) e de reatividade e estrutura\/ mec\u00e2nica vascular (em an\u00e9is de condut\u00e2ncia e resist\u00eancia); al\u00e9m de an\u00e1lises bioqu\u00edmicas, moleculares e de microscopia de fluoresc\u00eancia.<\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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\n\t\t\t\t\t\t\t\tAcesse a p\u00e1gina do grupo de pesquisa do CNPq\t\t\t\t\t\t\t<\/h3>\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t
\n\t\t\t\t\t\t\t\tSistema Vascular: Fisiologia e Fisiopatologia\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t
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\n\t\t\t\t\t\t\tAcesse a p\u00e1gina do grupo de pesquisa do CNPq\t\t\t\t\t\t<\/h3>\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t
\n\t\t\t\t\t\t\tSistema Vascular: Fisiologia e Fisiopatologia\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\tClique Aqui\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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<\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Financiamento Financiamento Conhe\u00e7a os projetos associados ao Laborat\u00f3rio de Fisiologia Vascular Acesse a p\u00e1gina da chefe do Laborat\u00f3rio de Fisiologia Cardiovascular na Biblioteca Virtual da FAPESP Clique Aqui Os projetos do Laborat\u00f3rio de Fisiologia Vascular possuem apoio das ag\u00eancias de fomento FAPESP (Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo), CNPq (Conselho Nacional[…]<\/a><\/p>\n","protected":false},"author":22540,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-396","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/sites.usp.br\/labvasc_icb\/wp-json\/wp\/v2\/pages\/396","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.usp.br\/labvasc_icb\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.usp.br\/labvasc_icb\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.usp.br\/labvasc_icb\/wp-json\/wp\/v2\/users\/22540"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.usp.br\/labvasc_icb\/wp-json\/wp\/v2\/comments?post=396"}],"version-history":[{"count":4,"href":"https:\/\/sites.usp.br\/labvasc_icb\/wp-json\/wp\/v2\/pages\/396\/revisions"}],"predecessor-version":[{"id":1886,"href":"https:\/\/sites.usp.br\/labvasc_icb\/wp-json\/wp\/v2\/pages\/396\/revisions\/1886"}],"wp:attachment":[{"href":"https:\/\/sites.usp.br\/labvasc_icb\/wp-json\/wp\/v2\/media?parent=396"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}