{"id":181,"date":"2024-02-09T19:00:53","date_gmt":"2024-02-09T21:00:53","guid":{"rendered":"https:\/\/sites.usp.br\/lambs\/?page_id=181"},"modified":"2025-07-24T12:34:40","modified_gmt":"2025-07-24T14:34:40","slug":"research","status":"publish","type":"page","link":"https:\/\/sites.usp.br\/lambs\/research\/","title":{"rendered":"Research"},"content":{"rendered":"<h4>Mathematical modeling of infectious diseases<\/h4>\n<p>We study the dynamics of infectious diseases using mathematical tools and techniques to \u00a0<a href=\"https:\/\/doi.org\/10.1371\/journal.pcbi.1007377\"><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-311 alignleft\" src=\"https:\/\/sites.usp.br\/lambs\/wp-content\/uploads\/sites\/1421\/2024\/02\/FigureLAMBS_modeling-300x300.png\" alt=\"\" width=\"348\" height=\"348\" srcset=\"https:\/\/sites.usp.br\/lambs\/wp-content\/uploads\/sites\/1421\/2024\/02\/FigureLAMBS_modeling-300x300.png 300w, https:\/\/sites.usp.br\/lambs\/wp-content\/uploads\/sites\/1421\/2024\/02\/FigureLAMBS_modeling-1024x1024.png 1024w, https:\/\/sites.usp.br\/lambs\/wp-content\/uploads\/sites\/1421\/2024\/02\/FigureLAMBS_modeling-150x150.png 150w, https:\/\/sites.usp.br\/lambs\/wp-content\/uploads\/sites\/1421\/2024\/02\/FigureLAMBS_modeling-768x768.png 768w, https:\/\/sites.usp.br\/lambs\/wp-content\/uploads\/sites\/1421\/2024\/02\/FigureLAMBS_modeling-45x45.png 45w, https:\/\/sites.usp.br\/lambs\/wp-content\/uploads\/sites\/1421\/2024\/02\/FigureLAMBS_modeling-200x200.png 200w, https:\/\/sites.usp.br\/lambs\/wp-content\/uploads\/sites\/1421\/2024\/02\/FigureLAMBS_modeling-400x400.png 400w, https:\/\/sites.usp.br\/lambs\/wp-content\/uploads\/sites\/1421\/2024\/02\/FigureLAMBS_modeling.png 1350w\" sizes=\"auto, (max-width: 348px) 100vw, 348px\" \/><\/a>simulate and understand the spread, transmission, and control of various infectious diseases. Through sophisticated and parsimonious modeling approaches, we aim to uncover insights into the complex host-pathogen and environment interactions. Our research explores the efficacy of intervention strategies, the impact of demographic factors, and the dynamics of emerging infectious threats with the ultimate goal of informing public health policies and combating infectious diseases worldwide.<\/p>\n<p>Examples: <a href=\"https:\/\/doi.org\/10.1371\/journal.pcbi.1007377\">Corder <em>et al.,<\/em> 2020<\/a>; <a href=\"https:\/\/doi.org\/10.1371\/journal.pntd.0008526\">Corder <em>et al.,<\/em> 2020<\/a>;\u00a0<a href=\"https:\/\/doi.org\/10.1016\/j.lana.2021.100169\">Ferreira <em>et al.<\/em>, 2022<\/a>.<\/p>\n<p><!--more--><!--more--><\/p>\n<h4>Genetics-based strategies to control mosquito-borne diseases<\/h4>\n<p><a href=\"https:\/\/doi.org\/10.1073\/pnas.2221118120\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-312 alignright\" src=\"https:\/\/sites.usp.br\/lambs\/wp-content\/uploads\/sites\/1421\/2024\/02\/FigureLAMBS_genetic-225x300.png\" alt=\"\" width=\"285\" height=\"380\" srcset=\"https:\/\/sites.usp.br\/lambs\/wp-content\/uploads\/sites\/1421\/2024\/02\/FigureLAMBS_genetic-225x300.png 225w, https:\/\/sites.usp.br\/lambs\/wp-content\/uploads\/sites\/1421\/2024\/02\/FigureLAMBS_genetic-768x1024.png 768w, https:\/\/sites.usp.br\/lambs\/wp-content\/uploads\/sites\/1421\/2024\/02\/FigureLAMBS_genetic-1152x1536.png 1152w, https:\/\/sites.usp.br\/lambs\/wp-content\/uploads\/sites\/1421\/2024\/02\/FigureLAMBS_genetic-400x533.png 400w, https:\/\/sites.usp.br\/lambs\/wp-content\/uploads\/sites\/1421\/2024\/02\/FigureLAMBS_genetic.png 1200w\" sizes=\"auto, (max-width: 285px) 100vw, 285px\" \/><\/a>Genetics-based vector population modification approaches (also called \u201creplacement\u201d) involve introducing genes that prevent parasite transmission into wild mosquito populations and have several predicted attractive features. In addition to sustainability, they leave no \u201cempty\u201d ecological niche open to invasive species, and thus may be neutral in their environmental impact. Leveraging experimental data, we employ mathematical modeling techniques to gain insights into the efficacy and implications of these genetic interventions.<\/p>\n<p>Examples: <a href=\"https:\/\/doi.org\/10.1073\/pnas.2221118120\">Carballar-Lejaraz\u00fa <em>et al.<\/em>, 2023<\/a>; <a href=\"https:\/\/doi.org\/10.1038\/s41467-024-54210-4\">Auradkar <em>et al.<\/em>, 2024;<\/a> <a href=\"https:\/\/doi.org\/10.1038\/s41586-025-09283-6\">Li et al., 2025<\/a>.<\/p>\n<p><!--more--><!--more--><\/p>\n<h4>Synchronization in heterogeneous networks<\/h4>\n<p>Synchronization stands as a pivotal phenomenon in networks, exerting a profound impact across a spectrum of disciplines, including biology, chemistry, and physics, and various man-made systems. <a href=\"https:\/\/doi.org\/10.1063\/5.0173546\"><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-213 aligncenter\" src=\"https:\/\/sites.usp.br\/lambs\/wp-content\/uploads\/sites\/1421\/2024\/02\/Highlight_Image-300x145.jpg\" alt=\"\" width=\"612\" height=\"296\" srcset=\"https:\/\/sites.usp.br\/lambs\/wp-content\/uploads\/sites\/1421\/2024\/02\/Highlight_Image-300x145.jpg 300w, https:\/\/sites.usp.br\/lambs\/wp-content\/uploads\/sites\/1421\/2024\/02\/Highlight_Image-1024x494.jpg 1024w, https:\/\/sites.usp.br\/lambs\/wp-content\/uploads\/sites\/1421\/2024\/02\/Highlight_Image-768x370.jpg 768w, https:\/\/sites.usp.br\/lambs\/wp-content\/uploads\/sites\/1421\/2024\/02\/Highlight_Image-1536x741.jpg 1536w, https:\/\/sites.usp.br\/lambs\/wp-content\/uploads\/sites\/1421\/2024\/02\/Highlight_Image-2048x988.jpg 2048w, https:\/\/sites.usp.br\/lambs\/wp-content\/uploads\/sites\/1421\/2024\/02\/Highlight_Image-400x193.jpg 400w\" sizes=\"auto, (max-width: 612px) 100vw, 612px\" \/><\/a>Notably, recent investigations unveiled the phenomenon of chaotic units achieving sustained and stable cluster synchronization within heterogeneous networks. Because many real-world systems rely on cluster synchronization for their functioning and natural systems often comprise individuals with varying connection counts, understanding the fundamental mechanisms that underlie the spark of synchrony in heterogeneous networks holds promise for elucidating innovative control strategies that amplify coherence among interacting entities.<\/p>\n<p>Examples: <a href=\"https:\/\/doi.org\/10.1063\/5.0169628\">Corder <em>et al.<\/em>, 2023<\/a>; <a href=\"https:\/\/doi.org\/10.1063\/5.0173546\">Montalb\u00e1n and Corder, 2024<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Mathematical modeling of infectious diseases We study the dynamics of infectious diseases using mathematical tools and techniques to \u00a0simulate and understand the spread, transmission, and control of various infectious diseases. Through sophisticated and parsimonious modeling approaches, we aim to uncover insights into the complex host-pathogen and environment interactions. Our research explores the efficacy of intervention [&hellip;]<\/p>\n","protected":false},"author":23934,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-181","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/sites.usp.br\/lambs\/wp-json\/wp\/v2\/pages\/181","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.usp.br\/lambs\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.usp.br\/lambs\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.usp.br\/lambs\/wp-json\/wp\/v2\/users\/23934"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.usp.br\/lambs\/wp-json\/wp\/v2\/comments?post=181"}],"version-history":[{"count":5,"href":"https:\/\/sites.usp.br\/lambs\/wp-json\/wp\/v2\/pages\/181\/revisions"}],"predecessor-version":[{"id":484,"href":"https:\/\/sites.usp.br\/lambs\/wp-json\/wp\/v2\/pages\/181\/revisions\/484"}],"wp:attachment":[{"href":"https:\/\/sites.usp.br\/lambs\/wp-json\/wp\/v2\/media?parent=181"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}