{"id":704,"date":"2021-09-04T22:19:12","date_gmt":"2021-09-05T00:19:12","guid":{"rendered":"https:\/\/sites.usp.br\/lemmcbeta\/?page_id=704"},"modified":"2021-10-17T01:06:04","modified_gmt":"2021-10-17T03:06:04","slug":"linha-de-pesquisa","status":"publish","type":"page","link":"https:\/\/sites.usp.br\/lemmcbeta\/en\/linha-de-pesquisa\/","title":{"rendered":"Linha de pesquisa"},"content":{"rendered":"\t\t
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Research lines<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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<\/span><\/p>

At LEMMC\u03b2, we aim to understand the molecular mechanisms involved in \u03b2 cell dysfunction and death leading to the development of Diabetes <\/span>mellitus <\/span><\/i>(DM). Different transcription factors and signaling pathways are involved in these alterations observed in \u03b2 cells and contribute to the development of the disease.<\/span><\/p>

Currently, we are conducting three research lines. First, evaluating the effects of NADPH oxidase isoenzymes, which plays an important role in oxidative stress and in insulin secretion capacity in \u03b2 cells. Second, we study the role of the transcription factor HNF-4\u03b1 in \u03b2 cell function and viability. Finally, the third aims to understand the mechanisms involved in the beneficial effects of physical exercise in preserving \u03b2 cells in T1DM animal models.<\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Projects<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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  • \n\t\t\t\t\t\t\t\t\t\tCharacterization of expression, localization and modulation of NADPH oxidases by proinflammatory cytokines in pancreatic \u03b2 cells<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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    • \n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\tTeam:<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t
    • \n\t\t\t\t\t\t\t\t\t\tFernanda Ortis, Angelo Rafael Carpinelli,
      Fernando Rodrigues Moraes Abdulkader,
      Davidson Correa de Almeida and Gabriel Maia da Silveira<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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      • \n\t\t\t\t\t\t\t\t\t\tCharacterization of expression, localization and modulation of NADPH oxidases by proinflammatory cytokines in pancreatic \u03b2 cells<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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        • \n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\tTeam:<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t
        • \n\t\t\t\t\t\t\t\t\t\tFernanda Ortis, Angelo Rafael Carpinelli, Fernando Rodrigues Moraes Abdulkader, Davidson Correa de Almeida and Gabriel Maia da Silveira<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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