{"id":607,"date":"2021-08-27T23:38:33","date_gmt":"2021-08-28T01:38:33","guid":{"rendered":"https:\/\/sites.usp.br\/lemmcbeta\/?page_id=607"},"modified":"2021-11-19T12:31:23","modified_gmt":"2021-11-19T14:31:23","slug":"pagina-inicial","status":"publish","type":"page","link":"https:\/\/sites.usp.br\/lemmcbeta\/","title":{"rendered":"P\u00e1gina Inicial"},"content":{"rendered":"\t\t
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LABORAT\u00d3RIO DE ESTUDOS DOS MECANISMOS DE MORTE DA C\u00c9LULA \u03b2 - LEMMC\u03b2 <\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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\n\t\t\t\t\t\t\tUtilizar o conhecimento dos mecanismos moleculares de disfun\u00e7\u00e3o e morte da c\u00e9lula \u03b2 no desenvolvimento de estrat\u00e9gias que permitam a preven\u00e7\u00e3o e destrui\u00e7\u00e3o delas durante a insulite e tamb\u00e9m ap\u00f3s o transplante de ilhotas de Langerhans em modelos cl\u00ednicos da doen\u00e7a e posteriormente em pacientes. \t\t\t\t\t\t<\/div>\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\tCONHE\u00c7A NOSSAS LINHAS DE PESQUISA \t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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O Laborat\u00f3rio de Estudos dos Mecanismos de Morte da C\u00e9lula \u03b2 busca elucidar os mecanismos moleculares envolvidos na indu\u00e7\u00e3o da morte e disfun\u00e7\u00e3o de c\u00e9lulas beta pancre\u00e1ticas que levam ao desenvolvimento do Diabetes <\/span>mellitus<\/span><\/i>. Essas c\u00e9lulas s\u00e3o respons\u00e1veis pela produ\u00e7\u00e3o da insulina, o horm\u00f4nio hipoglicemiante, dessa forma, sua disfun\u00e7\u00e3o ou morte acarreta na hiperglicemia cr\u00f4nica observada no Diabetes <\/span>mellitus<\/span><\/i>.<\/span><\/p>

Atualmente investigamos os mecanismos moleculares que culminam da disfun\u00e7\u00e3o e morte desta c\u00e9lula principalmente em modelos de Diabetes <\/span>mellitus<\/span><\/i> do tipo 1, com \u00eanfase no papel do fator de transcri\u00e7\u00e3o HNF-4\u0251 e das enzimas da fam\u00edlia das NADPH oxidases. Al\u00e9m disso, avaliamos os mecanismos envolvidos no efeito ben\u00e9fico do exerc\u00edcio f\u00edsico na prote\u00e7\u00e3o de c\u00e9lulas beta em modelo de Diabetes <\/span>mellitus<\/span><\/i> do tipo 1.<\/span><\/p>

Um melhor entendimento dessas vias possibilita o uso desse conhecimento no desenvolvimento de estrat\u00e9gias que permitam a preven\u00e7\u00e3o da destrui\u00e7\u00e3o das c\u00e9lulas beta durante a insulite e tamb\u00e9m ap\u00f3s o transplante de ilhotas de Langerhans em modelos cl\u00ednicos da doen\u00e7a e posteriormente em pacientes. <\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Imunofluoresc\u00eancia para identifica\u00e7\u00e3o de c\u00e9lulas positivas para insulina (c\u00e9lulas \u03b2 pancre\u00e1ticas) em ilhotas de animal controle (esquerda) ou diab\u00e9tico (direita). Insulina em verde (Alexa Fluor 488) e n\u00facleos em azul (DAPI). Aumento original 40X <\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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<\/div>
ENTENDA A DIABETES <\/div>
Voc\u00ea sabe as principais informa\u00e7\u00f5es sobre a Diabetes mellitus<\/i>? <\/div>SAIBA MAIS <\/a><\/div><\/div><\/div>
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CONHE\u00c7A A NOSSA EQUIPE <\/div>
Saiba quem s\u00e3o os membros atuais e ex-participantes do LEMMC\u03b2 <\/div>SAIBA MAIS <\/a><\/div><\/div><\/div>
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ATIVIDADES DO GRUPO <\/div>
Fique por dentro dos principais eventos do grupo <\/div>SAIBA MAIS <\/a><\/div><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t
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<\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

LABORAT\u00d3RIO DE ESTUDOS DOS MECANISMOS DE MORTE DA C\u00c9LULA \u03b2 – LEMMC\u03b2 OBJETIVO Utilizar o conhecimento dos mecanismos moleculares de disfun\u00e7\u00e3o e morte da c\u00e9lula \u03b2 no desenvolvimento de estrat\u00e9gias que permitam a preven\u00e7\u00e3o e destrui\u00e7\u00e3o delas durante a insulite e tamb\u00e9m ap\u00f3s o transplante de ilhotas de Langerhans em modelos cl\u00ednicos da doen\u00e7a e[…]<\/a><\/p>\n","protected":false},"author":22523,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-607","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/sites.usp.br\/lemmcbeta\/wp-json\/wp\/v2\/pages\/607","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.usp.br\/lemmcbeta\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.usp.br\/lemmcbeta\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.usp.br\/lemmcbeta\/wp-json\/wp\/v2\/users\/22523"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.usp.br\/lemmcbeta\/wp-json\/wp\/v2\/comments?post=607"}],"version-history":[{"count":4,"href":"https:\/\/sites.usp.br\/lemmcbeta\/wp-json\/wp\/v2\/pages\/607\/revisions"}],"predecessor-version":[{"id":1779,"href":"https:\/\/sites.usp.br\/lemmcbeta\/wp-json\/wp\/v2\/pages\/607\/revisions\/1779"}],"wp:attachment":[{"href":"https:\/\/sites.usp.br\/lemmcbeta\/wp-json\/wp\/v2\/media?parent=607"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}