Produções Científicas 4 de novembro de 2024 Lorena Lôbo de Figueiredo Pontes ARTIGOS RECENTES Early death and intracranial hemorrhage prediction in acute promyelocytic leukemia: validation of a risk score in a cohort from an international consortium treated with chemotherapy plus all-trans retinoic acid Mesenchymal stromal cells secretory pattern contributes to oncoinflammatory bone marrow microenvironment in polycythemia vera Platelets display immunophenotypic alterations and dysregulated transcriptomic signature in Philadelphia-negative myeloproliferative neoplasms Chronic inflammation deters natural killer cell fitness and cytotoxicity in myeloid leukemia Microcosting analysis of haematopoietic stem cell transplantation and chemotherapy with intermediate doses of cytarabine in the treatment of acute myeloid leukaemia Kinetics of BCR::ABL1 transcript levels and molecular relapse after tyrosine kinase inhibitors discontinuation in chronic myeloid leukemia patients: preliminary results from the DES-CML study Clinical networking results in continuous improvement of the outcome of patients with acute promyelocytic leukemia Diagnosis and management of acute promyelocytic leukemia: Brazilian consensus guidelines 2024 on behalf of the Brazilian Association of Hematology, Hemotherapy and Cellular Therapy Prognostic implications of ΔNp73/TAp73 expression ratio in core-binding factor acute myeloid leukemia Ratio of stemness to interferon signalling as a biomarker and therapeutic target of myeloproliferative neoplasm progression to acute myeloid leukaemia Suppression of multiple anti-apoptotic BCL2 family proteins recapitulates the effects of JAK2 inhibitors in JAK2V617F driven myeloproliferative neoplasms Bioactive Lipids as Chronic Myeloid Leukemia’s Potential Biomarkers for Disease Progression and Response to Tyrosine Kinase Inhibitors Response to NK cell content does not seem to influence engraftment in ex vivo T cell depleted haploidentical stem cell transplantation Differential cytotoxic activity of pharmacological inhibitors of IGF1R-related pathways in JAK2V617F driven cells Hippo pathway-related genes expression is deregulated in myeloproliferative neoplasms Altered distribution and function of NK-cell subsets lead to impaired tumor surveillance in JAK2V617F myeloproliferative neoplasms Philadelphia-negative myeloproliferative neoplasms display alterations in monocyte subpopulations frequency and immunophenotype Clinical significance of mitochondrial DNA content in acute promyelocytic leukaemia Multicentric standardization of minimal/measurable residual disease in B-cell precursor acute lymphoblastic leukaemia using next-generation flow cytometry in a low/middle-level income country 67th ASH Annual Meeting & Exposition EARLY FLOW CYTOMETRY-BASED MRD PREDICTS RELAPSE IN INTERMEDIATE-RISK AML FROM LOW- AND MIDDLE-INCOME COUNTRIESOF MUTATIONAL PATTERNS AND THEIR IMPACT ON THE IMMUNE EXPLORATION OF MUTATIONAL PATTERNS AND THEIR IMPACT ON THE IMMUNE MICROENVIRONMENT IN ACUTE MYELOID LEUKEMIA THROUGH IN SILICO ANALYSES ADVANCED MYELOFIBROSIS IS MARKED BY LOSS OF NKG2D AND DNAM-1 NK ACTIVATING SIGNALING AND INCREASED TIM-3 T CD8 EXHAUSTION FLT3-ITD mutation promotes leukemic differentiation toward an immature cytotoxic stage HEMO 2025 EXPLORATION OF MUTATIONAL PATTERNS AND THEIR IMPACT ON THE IMMUNE EXPLORATION OF MUTATIONAL PATTERNS AND THEIR IMPACT ON THE IMMUNE MICROENVIRONMENT IN ACUTE MYELOID LEUKEMIA THROUGH IN SILICO ANALYSES FLT3-ITD MUTATION PROMOTES LEUKEMIC DIFFERENTIATION TOWARDS AN IMMATURE CYTOTOXIC STAGE IMMUNE EVASION IN AML: NK CELL LIGAND ALTERATIONS LINKED TO LEUKEMIC STEM CELL PERSISTENCE IMMUNE MATURATION AND CHECKPOINT DYNAMICS DURING TYROSINE KINASE INHIBITOR DOSE REDUCTION PREDICT RELAPSE RISK IN PATIENTS WITH CHRONIC MYELOID LEUKEMIA UNDERGOING TREATMENT DISCONTINUATION IMMUNE SENESCENCE AND EXHAUSTION PHENOTYPE MARKED BY LOSS OF NKG2D AND DNAM-1 NK ACTIVATING SIGNALING AND INCREASED TIM-3 T CD8 CHARACTERIZES ADVANCED MYELOFIBROSIS EHA2025 Congress Immune Content of Mature and Licensed Cytotoxic Cells Is Associated with Treatment-Free Remission in Chronic Myeloid Leukemia T-Cell Memory Compartment Downregulation and NK Cell Activation Are Associated with Myelofibrosis ProgressionSIGNATURE OF LEUKEMIA ARREST STAGE IS ASSOCIATED WITH NPM1/FLT3 MUTATIONAL PROFILE AND PROGNOSIS IN ACUTE MYELOID LEUKEMIA NK2025 Congress Myelofibrosis Patients with CALR, MPL, or Other Clonal Mutations Exhibit Dysfunctional NK Cells with Increased KIR2DL1 Inhibition Hypermature but dysfunctional NK Cells is associated with Advanced Myelofibrosis 66th ASH Annual Meeting & Exposition Immune Content of Mature and Licensed Cytotoxic Cells Is Associated with Treatment-Free Remission in Chronic Myeloid Leukemia T-Cell Memory Compartment Downregulation and NK Cell Activation Are Associated with Myelofibrosis ProgressionSIGNATURE OF LEUKEMIA ARREST STAGE IS ASSOCIATED WITH NPM1/FLT3 MUTATIONAL PROFILE AND PROGNOSIS IN ACUTE MYELOID LEUKEMIA HEMO 2024 CYTOTOXIC IMMUNE CELLS MATURATION IN MYELOFIBROSIS: IMPLICATIONS FOR DISEASE PROGRESSION IMMUNOPHENOTYPIC SIGNATURE OF LEUKEMIA ARREST STAGE IS ASSOCIATED WITH NPM1/FLT3 MUTATIONAL PROFILE AND PROGNOSIS IN ACUTE MYELOID LEUKEMIA VALIDAÇÃO METODOLÓGICA NA ANÁLISE DE SUBPOPULAÇÕES LINFOCITÁRIAS ENTRE CITÔMETROS DE FLUXO HIGH LEUKEMIC STEM CELL FREQUENCY IN FLT3- MUTATED ACUTE MYELOID LEUKEMIA PATIENTS WITH NORMAL KARYOTYPE: IMPLICATIONS FOR PROGNOSIS IMPACT OF NK RECEPTOR AND LIGAND GENE EXPRESSION IN ACUTE MYELOID LEUKEMIA: A COMPUTATIONAL APPROACH IMMUNOLOGICAL PROFILES OF CYTOTOXIC CELLS IS ASSOCIATED WITH TREATMENT-FREE REMISSION IN CHRONIC MYELOID LEUKEMIA
