Science and Community

We seek within this area to reach out for the general public by communicating the work that is provided in our lab. 

Injury Sensing, Inflammation and Repair

This study axis seeks to understand how the immune system of different organs like the skin, intestine and kidney act to promote inflammation. We develop several models to study such conditions such as psoriasis, colitis and kidney damage promoted by ischemia reperfusion or by unilateral ureteral obstruction. Within each condition, a specific cell is targeted to modulate immune response and change the outcome of the disease. 

Microbiota and Organs-Kidney Axis

Up to date we know several organs have a commensal microbiota that not only control local homeostasis but also communicates with other organs. The commensals may send signals like short chain fatty acids or induce different immune cell types that communicate with the kidney and, therefore, modulates its physiology.DNA Repair and Immune System

During oxidative stress, reactive oxygen species (ROS) are produced, which can cause deleterious effects on cells in the microenvironment, such as DNA damage. To ensure DNA integrity, DNA repair systems are activated. These mechanisms can be activated against products generated by ROS. On the other hand, ROS modulate the metabolism of immune cells, which in turn influence the production of cytokines. Therefore, we are interested in understanding the mechanisms by which ROS modulated DNA damage in different types of immune cells and how this impacts the development of kidney diseases.Regulation of Immune Response and Cell Energy

In this field we sought to understand how cell metabolism functions as a hub to modulate effector responses from macrophages, T and B lymphocytes to epithelial cells like keratinocytes.