During oxidative stress, reactive oxygen species (ROS) are produced, which can cause deleterious effects on cells in the microenvironment, such as DNA damage. To ensure DNA integrity, DNA repair systems are activated. These mechanisms can be activated against products generated by ROS. On the other hand, ROS modulate the metabolism of immune cells, which in turn influence the production of cytokines. Therefore, we are interested in understanding the mechanisms by which ROS modulated DNA damage in different types of immune cells and how this impacts the development of kidney diseases