{"id":564,"date":"2024-11-11T12:08:17","date_gmt":"2024-11-11T14:08:17","guid":{"rendered":"https:\/\/sites.usp.br\/lmscc\/?page_id=564"},"modified":"2025-04-25T12:40:30","modified_gmt":"2025-04-25T14:40:30","slug":"publicacoes","status":"publish","type":"page","link":"https:\/\/sites.usp.br\/lmscc\/en\/publicacoes\/","title":{"rendered":"Publica\u00e7\u00f5es"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"564\" class=\"elementor elementor-564\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-41b63669 elementor-section-height-min-height elementor-section-boxed elementor-section-height-default elementor-section-items-middle\" data-id=\"41b63669\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-63452ec2\" data-id=\"63452ec2\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-16152b32 elementor-widget elementor-widget-theme-post-title elementor-page-title elementor-widget-heading\" data-id=\"16152b32\" data-element_type=\"widget\" data-widget_type=\"theme-post-title.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Publica\u00e7\u00f5es<\/h1>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-3065f06e elementor-reverse-mobile elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3065f06e\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-552dd4f6\" data-id=\"552dd4f6\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f2d321b elementor-widget elementor-widget-heading\" data-id=\"f2d321b\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">2025<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-e13aa2b\" data-id=\"e13aa2b\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a9e5a0f elementor-widget elementor-widget-text-editor\" data-id=\"a9e5a0f\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul><li>CHAGAS, Pablo Shimaoka; GARCIA, Cristiana Bernadelli; LEOPOLDINO, Andr\u00e9ia Machado.<span style=\"color: #000000;\"><a style=\"color: #000000;\" href=\"https:\/\/link.springer.com\/article\/10.1007\/s10528-025-11108-0#citeas\"><span style=\"font-weight: 400;\"> Genomic insights into oral cancer highlight mutant <\/span><i><span style=\"font-weight: 400;\">SIGMAR1<\/span><\/i><span style=\"font-weight: 400;\"> as a critical target to overcome chemoresistance. <\/span><\/a><\/span><i><span style=\"font-weight: 400;\">Biochemical Genetics<\/span><\/i><span style=\"font-weight: 400;\">, [S. l.], 2025.<\/span><\/li><\/ul>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-34479a1 elementor-reverse-mobile elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"34479a1\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-3acb9ec\" data-id=\"3acb9ec\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-de429da elementor-widget elementor-widget-heading\" data-id=\"de429da\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">2024<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-55535d6\" data-id=\"55535d6\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-21ce0b5 elementor-widget elementor-widget-text-editor\" data-id=\"21ce0b5\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul><li><span style=\"font-weight: 400;\">DA SILVA, GABRIEL; MILAN, THA\u00cdS MOR\u00c9 ; Leopoldino, Andr\u00e9ia Machado. <span style=\"color: #000000;\"><a style=\"color: #000000;\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0378111923009046?via%3Dihub\" data-wplink-edit=\"true\">The accumulation of sphingosine kinase 2 disrupts the DNA damage response and promotes resistance to genotoxic agents.<\/a><\/span> GENE, v. 897, p. 148063, 2024.<\/span><\/li><li><p><span style=\"font-weight: 400;\">FUGIO, LAIS BRIGLIADORI ; SILVA, GABRIEL ; FERRAZ, CAMILA LOPES ; TREVISAN, GLAUCE LUNARDELLI ; COELI-LACCHINI, FERNANDA BORCHERS ; GARCIA, CRISTIANA BERNADELLI ; SOUSA, LUCAS OLIVEIRA ; MALTA, TATHIANE MAISTRO ; GIL, CRISTIANE DAMAS ; Leopoldino, Andr\u00e9ia Machado . <span style=\"color: #000000;\"><a style=\"color: #000000;\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0167488923001891\">Accumulation of sphingosine kinase 2 protein induces malignant transformation in oral keratinocytes associated with stemness, autophagy, senescence, and proliferation.<\/a><\/span> BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, v. 1871, p. 119616, 2024.<\/span><\/p><\/li><li><p><span style=\"font-weight: 400;\">TORRES, LIZETH ANDREA TORRES ; SILVA, GABRIEL ; ALVES, JOVELINA SAMARA FERREIRA ; USHIDA, TATIANE RESENDE ; POTENZA, JULIA ; GARCIA, CRISTIANA BERNADELLI ; SOUSA, LUCAS OLIVEIRA ; LOPES, NORBERTO PEPORINE ; ALMEIDA, LUCIANA OLIVEIRA ; Leopoldino, Andr\u00e9ia Machado . <span style=\"color: #000000;\"><a style=\"color: #000000;\" href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jop.13498\">FTY720 increases paclitaxel efficacy in cisplatin-resistant oral squamous cell carcinoma.<\/a> <\/span>JOURNAL OF ORAL PATHOLOGY &amp;amp; MEDICINE, v.53(1), p. 42-52, 2024.<\/span><\/p><\/li><\/ul>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-2e017bb elementor-reverse-mobile elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"2e017bb\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-7d06dc6\" data-id=\"7d06dc6\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5e1bea1 elementor-widget elementor-widget-heading\" data-id=\"5e1bea1\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">2023<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-589bf0f\" data-id=\"589bf0f\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1346fa2 elementor-widget elementor-widget-text-editor\" data-id=\"1346fa2\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul><li><span style=\"font-weight: 400;\">COELI-LACCHINI, FERNANDA BORCHERS ; DA SILVA, GABRIEL ; BELENTANI, MONICA ; FERREIRA ALVES, JOVELINA SAMARA ; USHIDA, TATIANE RESENDE ; LUNARDELLI, GLAUCE TREVISAN ; GARCIA, CRISTIANA BERNADELLI ; SILVA, TARC\u00cdLIA APARECIDA ; LOPES, NORBERTO PEPORINE ; Leopoldino, Andr\u00e9ia Machado . <span style=\"color: #000000;\"><a style=\"color: #000000;\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0002944023003619?via%3Dihub\">Spermidine Suppresses Oral Carcinogenesis through Autophagy Induction, DNA Damage Repair, and Oxidative Stress Reduction.<\/a> <\/span>AMERICAN JOURNAL OF PATHOLOGY, v.193(12), p.2172-2181, 2023.<\/span><\/li><li><p><span style=\"font-weight: 400;\">SILVA, GABRIEL DA ; MILAN, THA\u00cdS MOR\u00c9 ; CHAGAS, PABLO SHIMAOKA ; TREVISAN, GLAUCE LUNARDELLI ; FERRAZ, CAMILA LOPES ; Leopoldino, Andr\u00e9ia Machado . <span style=\"color: #000000;\"><a style=\"color: #000000;\" href=\"https:\/\/www.tandfonline.com\/doi\/10.2217\/epi-2023-0297?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub%20%200pubmed\">SET protein as an epigenetics target.<\/a> <\/span>Epigenomics, v. 16(4), p. 249-257, 2023.<\/span><\/p><\/li><\/ul>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-ba91fe8 elementor-reverse-mobile elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"ba91fe8\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-5fa9ee1\" data-id=\"5fa9ee1\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2bd4db9 elementor-widget elementor-widget-heading\" data-id=\"2bd4db9\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">2022<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-f4cb710\" data-id=\"f4cb710\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-0bb967a elementor-widget elementor-widget-text-editor\" data-id=\"0bb967a\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul><li><span style=\"font-weight: 400;\">TAVARES, MARCELA OLIVEIRA ; MILAN, THA\u00cdS MOR\u00c9 ; BIGHETTI&#8217;TREVISAN, RAYANA LONGO ; Leopoldino, Andr\u00e9ia Machado ; DE ALMEIDA, LUCIANA OLIVEIRA . <span style=\"color: #000000;\"><a style=\"color: #000000;\" href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jop.13326\">Pharmacological inhibition of HDAC6 overcomes cisplatin chemoresistance by targeting cancer stem cells in oral squamous cell carcinoma.<\/a><\/span> JOURNAL OF ORAL PATHOLOGY &amp;amp; MEDICINE, v. x, p. x, 2022.<\/span><\/li><\/ul>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-0ccc48d elementor-reverse-mobile elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"0ccc48d\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-331e7aa\" data-id=\"331e7aa\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-9e1ad94 elementor-widget elementor-widget-heading\" data-id=\"9e1ad94\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">2021<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-523355f\" data-id=\"523355f\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4d8afb0 elementor-widget elementor-widget-text-editor\" data-id=\"4d8afb0\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul><li><p><span style=\"font-weight: 400;\">SILVA, G. ; KOWALSKI, L. P. ; MATOS, L. L. ; KULCSAR, M. ; Leopoldino, Andr\u00e9ia M. <span style=\"color: #000000;\"><a style=\"color: #000000;\" href=\"https:\/\/journals.sagepub.com\/doi\/abs\/10.3233\/CBM-203100?journalCode=cbma\">Profile of sphingolipid-related genes and its association with prognosis highlights sphingolipid metabolism in oral cancer.<\/a> C<\/span>ANCER BIOMARKERS, v. 32, p. 49-63, 2021.<\/span><\/p><\/li><li><span style=\"font-weight: 400;\">PADOVANI, KARINA STRINGHETTA ; GOTO, RENATA NISHIDA ; FUGIO, LAIS BRIGLIADORI ; GARCIA, CRISTIANA BERNADELLI ; ALVES, VANI MARIA ; BRASSESCO, MARIA SOL ; GREENE, LEWIS JOEL ; REGO, EDUARDO MAGALH\u00c3ES ; Leopoldino, Andr\u00e9ia Machado . <span style=\"color: #000000;\"><a style=\"color: #000000;\" href=\"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1002\/2211-5463.13210\">Crosstalk between hnRNP K and SET in ATRA induced differentiation in acute promyelocytic leukemia.<\/a> <\/span>FEBS Open Bio, v. x, p. x, 2021.<\/span><\/li><li><span style=\"font-weight: 400;\">ROMAN, R. F. ; SILVA, G. ; SILVA, R. M. ; USHIDA, T. R. ; SILVA, R. R. ; LACCHINI, R. ; MATOS, L. L. ; KOWALSKI, L. P. ; LOPES, N. P. ; Andr\u00e9ia M. Leopoldino . <span style=\"color: #000000;\"><a style=\"color: #000000;\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1388198121001852\">Sphingolipids signature in plasma and tissue as diagnostic and prognostic tools in oral squamous cell carcinoma.<\/a><\/span> BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, v. 1867, p. 159057, 2021.<\/span><\/li><\/ul>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-df5898e elementor-reverse-mobile elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"df5898e\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-1d54c64\" data-id=\"1d54c64\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-79147b7 elementor-widget elementor-widget-heading\" data-id=\"79147b7\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">2020<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-d9aac57\" data-id=\"d9aac57\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-0bfde15 elementor-widget elementor-widget-text-editor\" data-id=\"0bfde15\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul><li><p><span style=\"font-weight: 400;\">FUGIO, LAIS BRIGLIADORI ; COELI-LACCHINI, FERNANDA B. ; Leopoldino, Andr\u00e9ia Machado. <span style=\"color: #000000;\"><a style=\"color: #000000;\" href=\"https:\/\/www.mdpi.com\/2073-4409\/9\/3\/581\">Sphingolipids and Mitochondrial Dynamic<\/a><\/span>. Cells, v. 9, p. 581, 2020.<\/span><\/p><\/li><li><span style=\"font-weight: 400;\">SOUSA, LUCAS OLIVEIRA ; SOBRAL, LAYS MARTIN; DE ALMEIDA, LUCIANA OLIVEIRA; GARCIA, CRISTIANA BERNADELLI; GREENE, LEWIS JOEL; Leopoldino, Andr\u00e9ia Machado. <span style=\"color: #000000;\"><a style=\"color: #000000;\" href=\"https:\/\/www.tandfonline.com\/doi\/10.2217\/epi-2019-0181?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub%20%200pubmed\">SET protein modulates H4 histone methylation status and regulates miR-137 level in oral squamous cell carcinoma.<\/a><\/span> Epigenomics, v. x, p. epi-2019-0181, 2020.<\/span><\/li><li><span style=\"font-weight: 400;\">GOTO, RENATA NISHIDA ; SOBRAL, LAYS MARTIN; STRINGHETTA-PADOVANI, KARINA; GARCIA, CRISTIANA B. ; DA SILVA, GABRIEL ; VITEK, MICHAEL P. ; LEOPOLDINO, ANDREIA MACHADO. <span style=\"color: #000000;\"><a style=\"color: #000000;\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0014299920303605?via%3Dihub\">Synergic effect of OP449 and FTY720 on oral squamous cell carcinoma.<\/a><\/span> EUROPEAN JOURNAL OF PHARMACOLOGY, v. 882, p. 173268, 2020.<\/span><\/li><\/ul>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-4bf9ba4 elementor-reverse-mobile elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4bf9ba4\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-d61d8bf\" data-id=\"d61d8bf\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-46125bb elementor-widget elementor-widget-heading\" data-id=\"46125bb\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">2019<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-b6b9704\" data-id=\"b6b9704\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-0c0dd1f elementor-widget elementor-widget-text-editor\" data-id=\"0c0dd1f\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul><li><p><span style=\"font-weight: 400;\">OUCHIDA, A. T. ; TUDELLA, V. G. ; QUEIROZ, A. L. ; BRAUER, V.; CAVALCANTI NETO, M. P. ; Sousa, L.O.; Uyemura, S.A.; CURTI, C.; Andr\u00e9ia M Leopoldino. <span style=\"color: #000000;\"><a style=\"color: #000000;\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0167488919300035\">SET protein accumulation prevents cell death in head and neck squamous cell carcinoma through regulation of redox state and autophagy<\/a><\/span>. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, v. 1866, p. 623-637, 2019.<\/span><\/p><\/li><\/ul>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-17b0f8a elementor-reverse-mobile elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"17b0f8a\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-3e3872c\" data-id=\"3e3872c\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-df5715e elementor-widget elementor-widget-heading\" data-id=\"df5715e\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">2018<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-398d27b\" data-id=\"398d27b\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4a36915 elementor-widget elementor-widget-text-editor\" data-id=\"4a36915\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul><li><p><span style=\"font-weight: 400;\">LIMA, SANTIAGO ; TAKABE, KAZUAKI ; NEWTON, JASON ; SAURABH, KUMAR ; YOUNG, MEGAN M. ; LEOPOLDINO, ANDREIA MACHADO ; HAIT, NITAI C. ; ROBERTS, JANE L. ; WANG, HONG-GANG ; DENT, PAUL ; MILSTIEN, SHELDON ; BOOTH, LAURENCE ; SPIEGEL, SARAH. <span style=\"color: #000000;\"><a style=\"color: #000000;\" href=\"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/15548627.2018.1429875\">TP53 is required for BECN1- and ATG5-dependent cell death induced by sphingosine kinase 1 inhibition.<\/a><\/span> Autophagy, v. 11, p. 1-16, 2018.<\/span><\/p><\/li><li><p><span style=\"font-weight: 400;\">GOTO, RENATA NISHIDA ; SOBRAL, LAYS MARTIN ; SOUSA, LUCAS OLIVEIRA ; GARCIA, CRISTIANA BERNADELLI ; LOPES, NORBERTO PEPORINE ; MAR\u00cdN-PRIDA, JAVIER ; OCHOA-RODR\u00cdGUEZ, ESTAEL ; VERDECIA-REYES, YAMILA ; PARDO-ANDREU, GILBERTO L\u00c1ZARO ; Curti, Carlos ; Leopoldino, Andr\u00e9ia Machado. <span style=\"color: #000000;\"><a style=\"color: #000000;\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0014299917307884?via%3Dihub\">Anti-cancer activity of a new dihydropyridine derivative, VdiE-2N, in head and neck squamous cell carcinoma<\/a><\/span>. EUROPEAN JOURNAL OF PHARMACOLOGY, v. 819, p. 198-206, 2018.<\/span><\/p><\/li><\/ul>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-14ebb0f elementor-reverse-mobile elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"14ebb0f\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-bd18771\" data-id=\"bd18771\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c8569ac elementor-widget elementor-widget-heading\" data-id=\"c8569ac\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">2017<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-a0c8f5a\" data-id=\"a0c8f5a\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d66ded7 elementor-widget elementor-widget-text-editor\" data-id=\"d66ded7\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul><li><p><span style=\"font-weight: 400;\">Almeida, Luciana O. ; NETO, MARINALDO P. C. ; SOUSA, LUCAS O. ; TANNOUS, MARYNA A. ; Curti, Carlos ; Leopoldino, Andreia M. <span style=\"color: #000000;\"><a style=\"color: #000000;\" href=\"https:\/\/www.oncotarget.com\/article\/15818\/text\/\">SET oncoprotein accumulation regulates transcription through DNA demethylation and histone hypoacetylation.<\/a><\/span> OncoTarget, 8:26802-26818, 2017.<\/span><\/p><\/li><li><p><span style=\"font-weight: 400;\">Sobral, Lays M. ; COLETTA, R. D. ; ALBERICI, L. C. ; CURTI, C. ; Leopoldino, Andreia M. . <span style=\"color: #000000;\"><a style=\"color: #000000;\" href=\"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1111\/febs.14148\">SET\/I2PP2A overexpression induces phenotypic, molecular, and metabolic alterations in an oral keratinocyte cell line<\/a><\/span>. FEBS Journal, p. x, 2017.<\/span><\/p><\/li><\/ul>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-4d42f12 elementor-reverse-mobile elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4d42f12\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-13279ea\" data-id=\"13279ea\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5f7ee20 elementor-widget elementor-widget-heading\" data-id=\"5f7ee20\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">2016<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-2aceeac\" data-id=\"2aceeac\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-13277ac elementor-widget elementor-widget-text-editor\" data-id=\"13277ac\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul><li><p><span style=\"font-weight: 400;\">CAMPOS, L. ; RODRIGUEZ, Y. ; MACHADO LEOPOLDINO, A. ; HAIT, N. C. ; LOPEZ BERGAMI, P. ; CASTRO, M. ; SANCHEZ, E. ; MACEYKA, M. ; SPIEGEL, S. ; ALVAREZ, S. E. . <span style=\"color: #000000;\"><a style=\"color: #000000;\" href=\"https:\/\/www.tandfonline.com\/doi\/full\/10.1128\/MCB.00554-15\">Filamin A Expression Negatively Regulates Sphingosine-1-Phosphate-Induced NF- B Activation in Melanoma Cells by Inhibition of Akt Signaling<\/a><\/span>. Molecular and Cellular Biology (Print), v. 36, p. 320-329, 2016.<\/span><\/p><\/li><li><p><span style=\"font-weight: 400;\">SAYURI, C. M. ; ALMEIDA, L. O. ; GUIMARAES, D. M. ; MARTINS, M. D. ; PAPAGERAKIS, P. ; PAPAGERAKIS, S. ; LEOPOLDINO, A. M. ; CASTILHO, R. M. ; SQUARIZE, C. .<span style=\"color: #000000;\"><a style=\"color: #000000;\" href=\"https:\/\/www.oncotarget.com\/article\/9877\/text\/\"> PI3K-PTEN dysregulation leads to mTOR-driven upregulation of the core clock gene BMAL1 in normal and malignant epithelial cells<\/a><\/span>. OncoTarget, p. xx, 2016.<\/span><\/p><\/li><li><span style=\"font-weight: 400;\">SOUSA, LUCAS O ; SOBRAL, LAYS M ; MATSUMOTO, CAMILA S ; SAGGIORO, FABIANO P ; L\u00d3PEZ, ROSSANA V M ; PANEPUCCI, RODRIGO A ; Curti, Carlos ; SILVA, WILSON A ; GREENE, LEWIS J ; LEOPOLDINO, ANDR\u00c9IA M .<span style=\"color: #000000;\"><a style=\"color: #000000;\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2214647416300526\"> Lymph node or perineural invasion is associated with low miR-15a, miR-34c and miR-199b levels in head and neck squamous cell carcinoma<\/a><\/span>. BBA Clinical, v. x, p. xx-164, 2016.<\/span><\/li><\/ul>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-b53b701 elementor-reverse-mobile elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"b53b701\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-c60d2db\" data-id=\"c60d2db\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8c8945f elementor-widget elementor-widget-heading\" data-id=\"8c8945f\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">2015<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-0f12943\" data-id=\"0f12943\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-34707d9 elementor-widget elementor-widget-text-editor\" data-id=\"34707d9\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul><li><p><span style=\"font-weight: 400;\">Almeida, Luciana O. ; GOTO, RENATA N. ; NETO, MARINALDO P.C. ; SOUSA, LUCAS O. ; Curti, Carlos ; Leopoldino, Andr\u00e9ia M. <span style=\"color: #000000;\"><a style=\"color: #000000;\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0006291X15001436?via%3Dihub\">SET overexpression in HEK293 cells regulates mitochondrial uncoupling proteins levels within a mitochondrial fission\/reduced autophagic flux scenario<\/a><\/span>. Biochemical and Biophysical Research Communications (Print), v. xx, p. xx, 2015<\/span><\/p><\/li><\/ul>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-6c07860 elementor-reverse-mobile elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6c07860\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-eed623b\" data-id=\"eed623b\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-076e2b0 elementor-widget elementor-widget-heading\" data-id=\"076e2b0\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">2014<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-4ca15b4\" data-id=\"4ca15b4\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-fe027b6 elementor-widget elementor-widget-text-editor\" data-id=\"fe027b6\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul><li><p><span style=\"font-weight: 400;\">ALMEIDA, L. O. ; Garcia, C.B. ; SILVA, F. A. M.. ; CURTI, C. ; Leopoldino, Andr\u00e9ia M. <span style=\"color: #000000;\"><a style=\"color: #000000;\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0006291X14002186\">Accumulated SET protein up-regulates and interacts with hnRNPK, increasing its binding to nucleic acids, the Bcl-xS repression, and cellular proliferation.<\/a><\/span> Biochemical and Biophysical Research Communications (Print), p. xx, 2014.<\/span><\/p><\/li><li><p><span style=\"font-weight: 400;\">SILVA, V. B. ; Leopoldino, Andr\u00e9ia M. ; Tomich CHPS . <span style=\"color: #000000;\"><a style=\"color: #000000;\" href=\"https:\/\/www.ingentaconnect.com\/content\/ben\/cpc\/2014\/00000004\/00000001\/art00006\">In Silico Bioisosteric Replacements of hnRNP K Ligands as Anticancer Lead Compounds.<\/a><\/span> Current Physical Chemistry, v. 4, p. 30-34, 2014.<\/span><\/p><\/li><li><span style=\"font-weight: 400;\">SOBRAL, L. M. ; Sousa, L.O. ; COLETTA, R. D. ; GREENE, L. J. ; Tajara, E. H. S. ; GUTKIND, S. ; CURTI, C. ; Leopoldino, Andr\u00e9ia Machado . <span style=\"color: #000000;\"><a style=\"color: #000000;\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/1476-4598-13-32\">Stable SET knockdown in head and neck squamous cell carcinoma promotes cell invasion and the mesenchymal-like phenotype in vitro, as well as necrosis, cisplatin sensitivity and lymph node metastasis in xenograft tumor models.<\/a><\/span> Molecular Cancer, v. 13, p. 32, 2014.<\/span><\/li><li><span style=\"font-weight: 400;\">OLIVEIRA, M. G. ; FIGUEREDO, A. S. ; AQUINO, G. L. ; Leopoldino, Andreia M. ; SILVA, V. B. ; TAFT, C. A. ; Tomich CHPS . <span style=\"color: #000000;\"><a style=\"color: #000000;\" href=\"https:\/\/www.ingentaconnect.com\/content\/ben\/cbc\/2014\/00000010\/00000003\/art00005\">In Silico Design of Phenylbenzamide Derivatives Coupled to Pyrimidines as Novel hnRNP K Ligands Against Cancer<\/a><\/span>. Current Bioactive Compounds, v. 10, p. 158-162, 2014.<\/span><\/li><\/ul>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-a23423e elementor-reverse-mobile elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"a23423e\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-b095ab7\" data-id=\"b095ab7\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6d4cb2f elementor-widget elementor-widget-heading\" data-id=\"6d4cb2f\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">2012<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-a0d22cf\" data-id=\"a0d22cf\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6de42d4 elementor-widget elementor-widget-text-editor\" data-id=\"6de42d4\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul><li><p><span style=\"font-weight: 400;\">LEOPOLDINO, AM; Squarize, Cristiane H. ; Garcia, C.B. ; ALMEIDA, L. O. ; PESTANA, C. R. ; Uyemura, S.A. ; Tajara, EH ; GUTKIND, S. ; CURTI, C. . <span style=\"color: #000000;\"><a style=\"color: #000000;\" href=\"https:\/\/link.springer.com\/article\/10.1007\/s11010-011-1158-x\">Accumulation of the SET protein in HEK293T cells and mild oxidative stress: cell survival or death signaling<\/a><\/span>. Molecular and Cellular Biochemistry, v. 363, p. 65-74, 2012.<\/span><\/p><\/li><li><p><span style=\"font-weight: 400;\">ALMEIDA, L. O. ; GOTO, R. N. ; PESTANA, C. R. ; Uyemura, S.A. ; GUTKIND, S. ; CURTI, C. ; Leopoldino AM . <span style=\"color: #000000;\"><a style=\"color: #000000;\" href=\"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1111\/febs.12047\">SET overexpression decreases cell detoxification efficiency: ALDH2 and GSTP1 are downregulated, DDR is impaired and DNA damage accumulates.<\/a><\/span> The FEBS Journal (Print), v. 279, p. 4615-4628, 2012.<\/span><\/p><\/li><li><span style=\"font-weight: 400;\">Leopoldino, Andr\u00e9ia M.; Squarize, Cristiane H. ; Garcia, Cristiana B. ; Almeida, Luciana O. ; Pestana, Cezar R. ; Sobral, Lays M. ; Uyemura, S\u00e9rgio A. ; Tajara, Eloiza H. ; Silvio Gutkind, J. ; Curti, Carlos . <span style=\"color: #000000;\"><a style=\"color: #000000;\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1368837512001753?via%3Dihub\">SET protein accumulates in HNSCC and contributes to cell survival: Antioxidant defense, Akt phosphorylation and AVOs acidification.<\/a><\/span> Oral Oncology (1997), v. vol.x, p. xx-xx, 2012.<\/span><\/li><\/ul>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1501957 elementor-reverse-mobile elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1501957\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-58ffb31\" data-id=\"58ffb31\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-53edb43 elementor-widget elementor-widget-heading\" data-id=\"53edb43\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">2010<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-749d40f\" data-id=\"749d40f\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2a6ea01 elementor-widget elementor-widget-text-editor\" data-id=\"2a6ea01\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul><li><p><span style=\"font-weight: 400;\">CARREGARO, F. ; CARTA, A. ; LOBO, S. A. ; Tajara, EH ; LEOPOLDINO, AM . <span style=\"color: #000000;\"><a style=\"color: #000000;\" href=\"https:\/\/www.scielo.br\/j\/mioc\/a\/fSww49vhbDbrKbMQN9fXxcp\/?lang=en\">Polymorphisms IL10-819 and TLR-2 are potentially associated with sepsis in Brazilian patients.<\/a><\/span> Mem\u00f3rias do Instituto Oswaldo Cruz (Impresso), v. 105, p. 649-656, 2010.<\/span><\/p><\/li><\/ul>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-fa55e42 elementor-reverse-mobile elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"fa55e42\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-49b24ce\" data-id=\"49b24ce\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5e2135d elementor-widget elementor-widget-heading\" data-id=\"5e2135d\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">2007<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-7ca226d\" data-id=\"7ca226d\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-683b429 elementor-widget elementor-widget-text-editor\" data-id=\"683b429\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul><li><span style=\"font-weight: 400;\">LEOPOLDINO, AM; CARREGARO, F. ; Tomich CHPS ; Feitosa AO ; MANCINI, U. M. ; FREITAS, J. M. ; Tajara, E. H. S. . <span style=\"color: #000000;\"><a style=\"color: #000000;\" href=\"https:\/\/cdnsciencepub.com\/doi\/10.1139\/g07-016?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub%20%200pubmed\">Sequence and transcriptional study of HNRPK pseudogenes, and expression and molecular modeling analysis of hnRNP K isoforms<\/a><\/span>. Genome (Ottawa. Online), v. 50, p. 451-462, 2007.<\/span><\/li><\/ul>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-17966d0 elementor-reverse-mobile elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"17966d0\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-4c492f4\" data-id=\"4c492f4\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e370b57 elementor-widget elementor-widget-heading\" data-id=\"e370b57\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">2006<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-2736c71\" data-id=\"2736c71\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c2ed0a0 elementor-widget elementor-widget-text-editor\" data-id=\"c2ed0a0\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul><li><p><span style=\"font-weight: 400;\">LEOPOLDINO, AM; CANDURI, F ; CABRAL, H ; JUNQUEIRA, M ; DEMARQUI, A ; APPONI, L ; FONSECA, I ; DOMONT, G ; SANTOS, D ; VALENTINI, S . <span style=\"color: #000000;\"><a style=\"color: #000000;\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1046592806000659?via%3Dihub\">Expression, purification, and circular dichroism analysis of human CDK9.<\/a><\/span> Protein Expression and Purification, Netherlands, v. 47, p. 614-620, 2006.<\/span><\/p><\/li><\/ul>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-9c22813 elementor-reverse-mobile elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"9c22813\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-35e1d4d\" data-id=\"35e1d4d\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ed2cca8 elementor-widget elementor-widget-heading\" data-id=\"ed2cca8\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">2005<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-8a88e4a\" data-id=\"8a88e4a\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-eb92ab1 elementor-widget elementor-widget-text-editor\" data-id=\"eb92ab1\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul><li><p><span style=\"font-weight: 400;\">Bavoux C ; LEOPOLDINO, AM ; Ogi T ; Bieth A ; Kumari A ; Lehmann A ; PENA, S. D. J. ; Renato Machado C ; Hoffmann JS ; Cazaux C . Misregulation of the error-prone DNA polymerase kappa promotes pleiotropic genetic disorders and tumorigenesis. Cancer Research, v. 65, n.1, p. 325-330, 2005.<\/span><\/p><\/li><li><p><span style=\"font-weight: 400;\">Anacleto, Charles ; Leopoldino, Andr\u00e9ia M. ; Rossi, Benedito ; Soares, Fernando A. ; Lopes, Ademar ; Rocha, Jos\u00e9 Cl\u00e1udio C. ; Caballero, Ot\u00e1via ; Camargo, Anamaria A. ; Simpson, Andrew J. G. ; Pena, S\u00e9rgio D. J. <span style=\"color: #000000;\"><a style=\"color: #000000;\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1476558605800648\">Colorectal Cancer &#8220;Methylator Phenotype&#8221;: Fact or Artifact?<\/a><\/span>. Neoplasia (New York), v. 7, n.4, p. 331-335, 2005.<\/span><\/p><\/li><\/ul>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-c7fdac5 elementor-reverse-mobile elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"c7fdac5\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-8f31249\" data-id=\"8f31249\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-19a832a elementor-widget elementor-widget-heading\" data-id=\"19a832a\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">2003<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-c7cb78a\" data-id=\"c7cb78a\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2d0d71e elementor-widget elementor-widget-text-editor\" data-id=\"2d0d71e\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul><li><p><span style=\"font-weight: 400;\">LEOPOLDINO, AM; PENA, S. D. J. . <span style=\"color: #000000;\"><a style=\"color: #000000;\" href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/humu.10153\">The mutational spectrum of human autosomal tetranucleotide microsatellites<\/a><\/span>. Human Mutation, EUA, v. 21, n.1, p. 71-79, 2003.<\/span><\/p><\/li><\/ul>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-464e5b2 elementor-reverse-mobile elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"464e5b2\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-1d48054\" data-id=\"1d48054\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f0c74b5 elementor-widget elementor-widget-heading\" data-id=\"f0c74b5\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">1999<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-89e6fac\" data-id=\"89e6fac\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b0d0e39 elementor-widget elementor-widget-text-editor\" data-id=\"b0d0e39\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul><li><p><span style=\"font-weight: 400;\">LEOPOLDINO, AM; CARVALHOI, M. R. S. ; AGUIAR, M. J. B. ; PENA, S. D. J. . <span style=\"color: #000000;\"><a style=\"color: #000000;\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC1734381\/\">Prevalence of Prader-Willi and Angelman syndromes among mentally retarded boys in Brazil<\/a><\/span>. Journal of Medical Genetics, EUA, v. 36, p. 498-498, 1999.<\/span><\/p><\/li><\/ul>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>2025 CHAGAS, Pablo Shimaoka; GARCIA, Cristiana Bernadelli; LEOPOLDINO, Andr\u00e9ia Machado. Genomic insights into oral cancer highlight mutant SIGMAR1 as a critical target to overcome chemoresistance. Biochemical Genetics, [S. l.], 2025. 2024 DA SILVA, GABRIEL; MILAN, THA\u00cdS MOR\u00c9 ; Leopoldino, Andr\u00e9ia Machado. The accumulation of sphingosine kinase 2 disrupts the DNA damage response and promotes resistance [&hellip;]<\/p>\n","protected":false},"author":24318,"featured_media":0,"parent":0,"menu_order":5,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-564","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/sites.usp.br\/lmscc\/en\/wp-json\/wp\/v2\/pages\/564","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.usp.br\/lmscc\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.usp.br\/lmscc\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.usp.br\/lmscc\/en\/wp-json\/wp\/v2\/users\/24318"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.usp.br\/lmscc\/en\/wp-json\/wp\/v2\/comments?post=564"}],"version-history":[{"count":4,"href":"https:\/\/sites.usp.br\/lmscc\/en\/wp-json\/wp\/v2\/pages\/564\/revisions"}],"predecessor-version":[{"id":934,"href":"https:\/\/sites.usp.br\/lmscc\/en\/wp-json\/wp\/v2\/pages\/564\/revisions\/934"}],"wp:attachment":[{"href":"https:\/\/sites.usp.br\/lmscc\/en\/wp-json\/wp\/v2\/media?parent=564"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}