{"id":914,"date":"2022-10-26T16:11:41","date_gmt":"2022-10-26T19:11:41","guid":{"rendered":"https:\/\/sites.usp.br\/menopausando\/?p=914"},"modified":"2022-10-26T16:17:06","modified_gmt":"2022-10-26T19:17:06","slug":"estetrol","status":"publish","type":"post","link":"https:\/\/sites.usp.br\/menopausando\/terapias\/estetrol\/","title":{"rendered":"ESTETROL: O NOVO ESTROG\u00caNIO"},"content":{"rendered":"

Entrevista com Jean-Michael Foidart<\/strong><\/h1>\n

O estrog\u00eanio \u00e9 um dos principais horm\u00f4nios sexuais femininos e \u00e9 respons\u00e1vel pelo amadurecimento do corpo, com est\u00edmulo para as formas curvil\u00edneas e o crescimento das mamas; pelo preparo do corpo da mulher para uma gesta\u00e7\u00e3o; pela manuten\u00e7\u00e3o dos ossos e bom funcionamento do cora\u00e7\u00e3o, entre outros. Na transi\u00e7\u00e3o para menopausa e p\u00f3s-menopausa, entretanto, h\u00e1 uma diminui\u00e7\u00e3o progressiva da produ\u00e7\u00e3o desse horm\u00f4nio no organismo (ov\u00e1rios), sendo os principais sintomas os fogachos (ondas de calor), altera\u00e7\u00f5es do sono e do humor, secura vaginal e outros sintomas urogenitais e sexuais. Para buscar aliviar esses sintomas, al\u00e9m do incentivo de h\u00e1bitos de vida saud\u00e1veis, h\u00e1 a terapia hormonal, com uso de estrog\u00eanio (isolado para mulheres sem \u00fatero) e combinado com progestag\u00eanio (nas composi\u00e7\u00f5es) sendo outro horm\u00f4nio sexual feminino. Uma das indica\u00e7\u00f5es cl\u00e1ssicas do uso de terapia hormonal \u00e9 a presen\u00e7a de sintomas moderados a intensos que prejudicam as atividades de vida di\u00e1ria das pacientes, al\u00e9m da s\u00edndrome geniturin\u00e1ria do climat\u00e9rio (ou\u00e7a nosso podcast no spotify <\/span>Menopausando USP | Podcast on Spotify<\/span><\/a>). Contudo, h\u00e1 contraindica\u00e7\u00f5es ou mulheres que n\u00e3o podem usar terap\u00eautica hormonal, como as mulheres com doen\u00e7as cardiovasculares pr\u00e9vias ou ativa, trombose pr\u00e9via\/familiar e c\u00e2ncer de mama em tratamento. Mas, estudos recentes demonstram que um novo estrog\u00eanio, o Estetrol, al\u00e9m de ser eficaz, ter\u00e1 propriedades bioqu\u00edmicas diferentes.\u00a0<\/span><\/p>\n

O Estetrol est\u00e1 presente na gesta\u00e7\u00e3o de seres humanos, n\u00e3o sendo encontrado em nenhuma outra esp\u00e9cie sendo sintetizado apenas pelo f\u00edgado fetal.\u00a0 Os estrog\u00eanios agem na ativa\u00e7\u00e3o de genes respons\u00e1veis pela prolifera\u00e7\u00e3o de c\u00e9lulas, entretanto, o estetrol consegue agir diretamente no bloqueio do efeito de alguns desses genes, sendo aqueles que apresentam uma a\u00e7\u00e3o muito fraca na estimula\u00e7\u00e3o da prolifera\u00e7\u00e3o das c\u00e9lulas. O Professor Jean-Michael Foidart, m\u00e9dico e pesquisador belga, professor honor\u00e1rio e co-diretor do Laborat\u00f3rio de Tumores e Desenvolvimento Biol\u00f3gico da Universidade de Li\u00e8ge, B\u00e9lgica,\u00a0 explica que a metaboliza\u00e7\u00e3o dos estrog\u00eanios no organismo \u00e9 feita de maneiras diferentes. Estetrol, \u00e9 absorvido no trato intestinal, entra na circula\u00e7\u00e3o sangu\u00ednea at\u00e9 chegar ao f\u00edgado para ser finalmente metabolizado.<\/span><\/p>\n

O Estetrol, todavia, n\u00e3o \u00e9 metabolizado por nenhuma das enzimas do f\u00edgado respons\u00e1veis pelas a\u00e7\u00f5es de intera\u00e7\u00e3o medicamentosa, ou seja, ao tomar outros medicamentos que afetam essas enzimas, o Estetrol \u00e9 pouco impactado e permanece com a mesma efic\u00e1cia.<\/span><\/p>\n

A boa not\u00edcia \u00e9 que o Estetrol vir\u00e1 em breve para o Brasil. Segundo o Professor Foidart explana, na composi\u00e7\u00e3o de p\u00edlula contraceptiva, o Estetrol ser\u00e1 mais um estrog\u00eanio utilizado para anticoncep\u00e7\u00e3o combinada (p\u00edlulas que cont\u00e9m estrog\u00eanio e progestag\u00eanio em sua composi\u00e7\u00e3o). Ainda, segundo o pesquisador, o Estetrol possui uma vida \u00fatil muito mais prolongada do que os outros estrog\u00eanios, o que permite que os tecidos continuem expostos \u00e0 quantidade significativa da mol\u00e9cula muito tempo ap\u00f3s ter tomado p\u00edlulas anticoncepcionais. O estetrol na anticoncep\u00e7\u00e3o vir\u00e1 em combina\u00e7\u00e3o com um progestag\u00eanio j\u00e1 utilizado e conhecido, que ser\u00e1 a combina\u00e7\u00e3o da p\u00edlula anticoncepcional Estetrol-Drospirenona.\u00a0<\/span><\/p>\n

Para saber mais sobre o assunto, assista \u00e0 entrevista completa feita com o Professor Foidart no nosso novo canal do youtube: <\/span>Menopausando USP – YouTube<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Entrevista com Jean-Michael Foidart O estrog\u00eanio \u00e9 um dos principais horm\u00f4nios sexuais femininos e \u00e9 respons\u00e1vel pelo amadurecimento do corpo, com est\u00edmulo para as formas curvil\u00edneas e o crescimento das mamas; pelo preparo do corpo da mulher para uma gesta\u00e7\u00e3o; pela manuten\u00e7\u00e3o dos ossos e bom funcionamento do cora\u00e7\u00e3o, entre outros. Na transi\u00e7\u00e3o para menopausa […]<\/p>\n","protected":false},"author":1,"featured_media":919,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[25],"tags":[30,32,37,36],"class_list":["post-914","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-terapias","tag-climaterio","tag-menopausa","tag-pos-menopausa","tag-terapia-hormonal","entry","has-media"],"yoast_head":"\nESTETROL: O NOVO ESTROG\u00caNIO - Menopausando<\/title>\n<meta name=\"description\" content=\"O estrog\u00eanio \u00e9 um dos principais horm\u00f4nios sexuais femininos, o estetrol \u00e9 um tipo novo de hormonio com possibilidades promissoras.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sites.usp.br\/menopausando\/terapias\/estetrol\/\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"ESTETROL: O NOVO ESTROG\u00caNIO - 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