{"id":1996,"date":"2026-04-29T10:59:23","date_gmt":"2026-04-29T12:59:23","guid":{"rendered":"https:\/\/sites.usp.br\/posbfm\/?page_id=1996"},"modified":"2026-04-29T11:04:22","modified_gmt":"2026-04-29T13:04:22","slug":"jose-donato-junior","status":"publish","type":"page","link":"https:\/\/sites.usp.br\/posbfm\/jose-donato-junior\/","title":{"rendered":"Jos\u00e9 Donato J\u00fanior"},"content":{"rendered":"\t\t
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Jos\u00e9 Donato J\u00fanior <\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Linhas de Pesquisa:\u00a0<\/strong><\/p>

Circuitos hipotal\u00e2micos que regulam o metabolismo e eixos end\u00f3crinos<\/strong><\/p>

Resumo: <\/strong>O hipot\u00e1lamo \u00e9 uma regi\u00e3o cerebral respons\u00e1vel pela regula\u00e7\u00e3o de fun\u00e7\u00f5es viscerais e da homeostase. Popula\u00e7\u00f5es espec\u00edficas de neur\u00f4nios hipotal\u00e2micos controlam a fome e ingest\u00e3o alimentar, o gasto energ\u00e9tico, a sensibilidade perif\u00e9rica e secre\u00e7\u00e3o de insulina, bem como outros aspectos metab\u00f3licos. Al\u00e9m disso, neur\u00f4nios hipotal\u00e2micos s\u00e3o os principais reguladores dos principais eixos end\u00f3crinos, incluindo o da tiroide, adrenal, reprodutivo e do crescimento. Nosso laborat\u00f3rio \u00e9 especializado no estudo de neur\u00f4nios hipotal\u00e2micos e de como fatores hormonais atuam no funcionamento dessas c\u00e9lulas a fim de causar altera\u00e7\u00f5es metab\u00f3licas e hormonais. Entre outros aspectos, temos estudado nos \u00faltimos anos o papel desempenhado pela sinaliza\u00e7\u00e3o central de v\u00e1rios horm\u00f4nios sobre neur\u00f4nios hipotal\u00e2micos, incluindo o estradiol, prolactina, citocinas pr\u00f3-inflamat\u00f3rias e mais especificamente o da leptina e horm\u00f4nio do crescimento. Utilizamos m\u00e9todos neuroanat\u00f4micos, histol\u00f3gicos, de biologia molecular e de manipula\u00e7\u00e3o g\u00eanica, para estudar a neurofisiologia dos circuitos hipotal\u00e2micos que regulam o metabolismo e eixos end\u00f3crinos. Entre os nossos principais achados 1) descrevemos como situa\u00e7\u00f5es que causam resist\u00eancia \u00e0 leptina predisp\u00f5em os animais \u00e0 obesidade; 2) investigamos fatores hormonais e moleculares que afetam o metabolismo durante e ap\u00f3s a gesta\u00e7\u00e3o e lacta\u00e7\u00e3o; 3) demonstramos que o horm\u00f4nio do crescimento tem uma a\u00e7\u00e3o ampla no sistema nervoso central regulando diversos aspectos, incluindo metabolismo; 4) estamos redefinindo os mecanismos centrais de controle da secre\u00e7\u00e3o puls\u00e1til do horm\u00f4nio do crescimento.<\/p>

\u00a0<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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\"\"\u00a0\u00a0\u00a0jdonato@icb.usp.br<\/a><\/span><\/span><\/strong><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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\"\"\u00a0\u00a0\u00a0Curr\u00edculo Lattes<\/a><\/span><\/strong><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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\"\"\u00a0\u00a0 + 55 (11) 3091-0929<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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\"\"\u00a0\u00a0 ICB I, Depto. Fisiologia, Laborat\u00f3rio de Neuroanatomia Funcional, Sala 234<\/a><\/strong><\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Jos\u00e9 Donato J\u00fanior Linhas de Pesquisa:\u00a0 Circuitos hipotal\u00e2micos que regulam o metabolismo e eixos end\u00f3crinos Resumo: O hipot\u00e1lamo \u00e9 uma regi\u00e3o cerebral respons\u00e1vel pela regula\u00e7\u00e3o de fun\u00e7\u00f5es viscerais e da […]<\/p>\n","protected":false},"author":24472,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-1996","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/sites.usp.br\/posbfm\/wp-json\/wp\/v2\/pages\/1996","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.usp.br\/posbfm\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.usp.br\/posbfm\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.usp.br\/posbfm\/wp-json\/wp\/v2\/users\/24472"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.usp.br\/posbfm\/wp-json\/wp\/v2\/comments?post=1996"}],"version-history":[{"count":4,"href":"https:\/\/sites.usp.br\/posbfm\/wp-json\/wp\/v2\/pages\/1996\/revisions"}],"predecessor-version":[{"id":2007,"href":"https:\/\/sites.usp.br\/posbfm\/wp-json\/wp\/v2\/pages\/1996\/revisions\/2007"}],"wp:attachment":[{"href":"https:\/\/sites.usp.br\/posbfm\/wp-json\/wp\/v2\/media?parent=1996"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}