{"id":268,"date":"2020-09-09T10:16:00","date_gmt":"2020-09-09T12:16:00","guid":{"rendered":"http:\/\/sites.usp.br\/ppggastro\/?page_id=268"},"modified":"2020-09-09T10:16:00","modified_gmt":"2020-09-09T12:16:00","slug":"mgt5774","status":"publish","type":"page","link":"https:\/\/sites.usp.br\/ppggastro\/mgt5774\/","title":{"rendered":"MGT5774"},"content":{"rendered":"

Relat\u00f3rio de Dados da Disciplina<\/h1>\n

\u00a0<\/strong><\/p>\n

Sigla:\u00a0 MGT5774 – 1\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Tipo: POS<\/p>\n

Nome: Medicina Translacional em Ci\u00eancias Gastroenterol\u00f3gicas: Genoma, Epigenoma, Patologia Molecular, Vias de Sinaliza\u00e7\u00e3o e Biobanco<\/p>\n

\u00c1rea: Ci\u00eancias em Gastroenterologia (5168)<\/p>\n

 <\/p>\n

Datas de aprova\u00e7\u00e3o<\/strong><\/p>\n

CCP: 19\/12\/2016\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 CPG: 20\/12\/2016\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 CoPGr:<\/p>\n

Data de ativa\u00e7\u00e3o: 20\/12\/2016\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Data de desativa\u00e7\u00e3o:<\/p>\n

 <\/p>\n

Carga hor\u00e1ria<\/strong><\/p>\n

Total: 90 h\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Te\u00f3rica: 8 h\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Pr\u00e1tica: 14 h\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Estudo: 8 h<\/p>\n

Cr\u00e9ditos: 6\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Dura\u00e7\u00e3o: 3 Semanas<\/p>\n

 <\/p>\n

Respons\u00e1veis<\/strong><\/p>\n

977511 – Fl\u00e1vio Henrique Ferreira Galvao – 20\/12\/2016 at\u00e9 data atual<\/p>\n

1666287 – Suzane Kioko Ono – 20\/12\/2016 at\u00e9 data atual<\/p>\n

 <\/p>\n

Objetivos<\/strong><\/p>\n

Medicina translacional tornou-se uma prioridade, mas ainda existe uma grande diferen\u00e7a entre a chegada de novos tratamentos e do investimento. Aqui viemos com o objetivo de discutir o processo translacional e oferecer solu\u00e7\u00f5es potenciais para um maior avan\u00e7o atrav\u00e9s de uma melhor integra\u00e7\u00e3o entre o cuidado com a sa\u00fade, investiga\u00e7\u00e3o acad\u00eamica e a ind\u00fastria. Primeiramente obter uma vis\u00e3o metodol\u00f3gica, seguida pela aplica\u00e7\u00e3o de modelos cient\u00edficos, e assim promover a valida\u00e7\u00e3o de estudos em gastroenterologia cl\u00ednica e cir\u00fargica.<\/p>\n

Oferecer aos alunos de p\u00f3s-gradua\u00e7\u00e3o aspectos pr\u00e1ticos da produ\u00e7\u00e3o cient\u00edfica:<\/p>\n

Estrat\u00e9gias de estudos em genoma, epigenoma, patologia molecular, vias de sinaliza\u00e7\u00e3o e biobanco, visando a pesquisa translacional e medicina personalizada<\/p>\n

 <\/p>\n

Justificativa<\/strong><\/p>\n

A ci\u00eancia b\u00e1sica n\u00e3o deve ser negligenciada, como transla\u00e7\u00e3o a pesquisa b\u00e1sica n\u00e3o se sustenta na aus\u00eancia de<\/p>\n

investiga\u00e7\u00e3o s\u00f3lida e fundamentada. Com isso, \u00e0 medida em que avan\u00e7amos tentando desenvolver novas terapias, nunca devemos esquecer que a pesquisa b\u00e1sica \u00e9 essencial para a medicina translacional.<\/p>\n

Finalmente, promover o racioc\u00ednio do aluno de p\u00f3s-gradua\u00e7\u00e3o em rela\u00e7\u00e3o \u00e0 an\u00e1lise cr\u00edtica de trabalhos cient\u00edficos e produ\u00e7\u00e3o cient\u00edfica, oferecendo instrumentos pr\u00e1ticos para desenvolver uma pesquisa em medicina translacional. O desenvolvimento de novas tecnologias e a ampla exposi\u00e7\u00e3o \u00e0 informa\u00e7\u00e3o exp\u00f5e os novos pesquisadores a novas \u00e1reas de conhecimento. Utilizando de maneira pr\u00e1tica tais ferramentas o aluno poder\u00e1 com maior facilidade desenvolver sua pesquisa e posteriormente demonstrar a sua utilidade na pr\u00e1tica cl\u00ednica.<\/p>\n

 <\/p>\n

Conte\u00fado<\/strong><\/p>\n

Basis of Translational Research<\/p>\n

Genomics and Epigenomics in Translational Research Biobancs<\/p>\n

Molecular pathogenesis and signalling pathways Clinical Trials Design<\/p>\n

Evaluation of Molecular Therapies<\/p>\n

 <\/p>\n

Bibliografia<\/strong><\/p>\n

Llovet JM, Villanueva A. Liver cancer: Effect of HCV clearance with direct-acting antiviral agents on HCC. Nat Rev Gastroenterol Hepatol. 2016 Oct;13(10):561-2.<\/p>\n

Bitar KN, Zakhem E. Bioengineering the gut: future prospects of regenerative medicine. Nat Rev Gastroenterol Hepatol. 2016 Sep;13(9):543-56.<\/p>\n

Moran S, Mart\u00ednez-Card\u00fas A, Sayols S, Musul\u00e9n E, Bala\u00f1\u00e1 C, Estival-Gonzalez A, Moutinho C,Epigenetic profiling to classify cancer of unknown primary: a multicentre, retrospective analysis. Lancet Oncol. 2016 Aug 26. pii: S1470- 2045(16)30297-2.<\/p>\n

Moeini A, Sia D, Bardeesy N, Mazzaferro V, Llovet JM. Molecular Pathogenesis and Targeted Therapies for Intrahepatic Cholangiocarcinoma. Clin Cancer Res. 2016 Jan 15;22(2):291-300.<\/p>\n

Alexandre PA, Kogelman LJ, Santana MH, Passarelli D, Pulz LH, Fantinato-Neto P, et al. Liver transcriptomic networks reveal main biological processes associated with feed efficiency in beef cattle. BMC Genomics. 2015;16:1063.<\/p>\n

Ogino S, Nishihara R, VanderWeele TJ, Wang M, Nishi A, Lochhead P, Qian ZR, et al. Review Article: The Role of Molecular Pathological Epidemiology in the Study of Neoplastic and Non-neoplastic Diseases in the Era of Precision Medicine. Epidemiology. 2016 Jul;27(4):602-11.<\/p>\n

Zhang DY, Goossens N, Guo J, Tsai MC, Chou HI, Altunkaynak C. A hepatic stellate cell gene expression signature associated with outcomes in hepatitis C cirrhosis and hepatocellular carcinoma after curative resection. Gut. 2016 Oct;65(10):1754-64.<\/p>\n

Moeini A, Sia D, Bardeesy N, Mazzaferro V, Llovet JM. Molecular Pathogenesis and Targeted Therapies for Intrahepatic Cholangiocarcinoma. Clin Cancer Res. 2016 Jan 15;22(2):291-300.<\/p>\n

Llovet JM. Molecular markers predicting outcome in hepatocellular carcinoma treated by liver transplantation. Liver Transpl. 2015 Nov;21 Suppl 1:S25-6.<\/p>\n

Torrecilla S, Llovet JM. New molecular therapies for hepatocellular carcinoma. Clin Res Hepatol Gastroenterol. 2015 Sep;39 Suppl 1:S80-5.<\/p>\n

Llovet JM, Villanueva A, Lachenmayer A, Finn RS. Advances in targeted therapies for hepatocellular carcinoma in the genomic era. Nat Rev Clin Oncol. 2015 Aug;12(8):436.<\/p>\n

Schulze K, Imbeaud S, Letouz\u00e9 E, Alexandrov LB, Calderaro J, Rebouissou S, et al. Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets. Nat Genet. 2015 May;47(5):505-11.<\/p>\n

Villanueva A, Portela A, Sayols S, Battiston C, Hoshida Y, M\u00e9ndez-Gonz\u00e1lez J, et al. DNA methylation-based prognosis and epidrivers in hepatocellular carcinoma. Hepatology. 2015 Jun;61(6):1945-56.<\/p>\n

 <\/p>\n

Forma de avalia\u00e7\u00e3o<\/strong><\/p>\n

Vide campo Observa\u00e7\u00e3o<\/p>\n

 <\/p>\n

Observa\u00e7\u00e3o<\/strong><\/p>\n

CRIT\u00c9RIOS DE AVALIA\u00c7\u00c3O<\/span><\/p>\n

A avalia\u00e7\u00e3o dos alunos se basear\u00e1 na presen\u00e7a e participa\u00e7\u00e3o nas atividades estabelecidas pelos respons\u00e1veis do curso; assim como, realiza\u00e7\u00e3o de busca bibliogr\u00e1fica sobre o assunto estudado; compress\u00e3o e interpreta\u00e7\u00e3o dos trabalhos cient\u00edficos; apresenta\u00e7\u00e3o de semin\u00e1rios e das tarefas.<\/p>\n

 <\/p>\n

OBSERVA\u00c7\u00d5ES<\/span><\/p>\n

A disciplina estar\u00e1 fundamentada em uma plataforma on-line, com o idioma bil\u00edngue ingl\u00eas e portugu\u00eas. Tendo como meta a utiliza\u00e7\u00e3o de bibliografia atualizada anual e de revistas\/jornais com fatores de impacto expressivos dentro dos t\u00f3picos gastroenterologia, hepatologia e transplantes.","protected":false},"excerpt":{"rendered":"

Relat\u00f3rio de Dados da Disciplina \u00a0 Sigla:\u00a0 MGT5774 – 1\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Tipo: POS Nome: Medicina Translacional em Ci\u00eancias Gastroenterol\u00f3gicas: Genoma, Epigenoma, Patologia Molecular, Vias de Sinaliza\u00e7\u00e3o e Biobanco \u00c1rea: Ci\u00eancias em Gastroenterologia (5168)   Datas de aprova\u00e7\u00e3o CCP: 19\/12\/2016\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 CPG: 20\/12\/2016\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 CoPGr: Data de ativa\u00e7\u00e3o: 20\/12\/2016\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Data de desativa\u00e7\u00e3o:   Carga hor\u00e1ria Total: 90 h\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Te\u00f3rica: […]<\/p>\n","protected":false},"author":21987,"featured_media":0,"parent":0,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-268","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/sites.usp.br\/ppggastro\/wp-json\/wp\/v2\/pages\/268","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.usp.br\/ppggastro\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.usp.br\/ppggastro\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.usp.br\/ppggastro\/wp-json\/wp\/v2\/users\/21987"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.usp.br\/ppggastro\/wp-json\/wp\/v2\/comments?post=268"}],"version-history":[{"count":4,"href":"https:\/\/sites.usp.br\/ppggastro\/wp-json\/wp\/v2\/pages\/268\/revisions"}],"predecessor-version":[{"id":301,"href":"https:\/\/sites.usp.br\/ppggastro\/wp-json\/wp\/v2\/pages\/268\/revisions\/301"}],"wp:attachment":[{"href":"https:\/\/sites.usp.br\/ppggastro\/wp-json\/wp\/v2\/media?parent=268"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}