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Multicenter, international, double-blind, placebo-controlled, parallel, controlled and randomized trial of a combination of low and fixed dose with antihypertensive effect (Triple Pill) as a standard treatment in patients with a history of acute ICH and levels of systolic blood pressure (SBP) defined as at least; high normal to high borderline (130 mmHg), and under minimal or no treatment for BP reduction according to current guidelines. Two-phase design. Phase 1: Determine the efficacy, tolerance, safety and adherence to a single low-dose, fixed-combination pill with an antihypertensive effect (Pill – telmisartan 20 mg, amlodipine 2.5 mg and indapamide 1.25 mg) compared to placebo in patients with recent acute stroke (stroke) due to spontaneous intraparenchymal cerebral hemorrhage (HIP). Phase 2: Determine the effectiveness of the most intensive reduction in blood pressure (BP) provided by a strategy as a standard treatment, at the time of the first occurrence of recurrent stroke after HIP.<\/p>\n
Further information: https:\/\/www.tridentstudy.org\/<\/a><\/p>\n <\/p>\n <\/p>\n","protected":false},"excerpt":{"rendered":" Multicenter, international, double-blind, placebo-controlled, parallel, controlled and randomized trial of a combination of low and fixed dose with antihypertensive effect (Triple Pill) as a standard treatment in patients with a history of acute ICH and levels of systolic blood pressure (SBP) defined as at least; high normal to high borderline (130 mmHg), and under[…]<\/a><\/p>\n","protected":false},"author":906,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-840","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/sites.usp.br\/rnpavc\/wp-json\/wp\/v2\/pages\/840","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.usp.br\/rnpavc\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.usp.br\/rnpavc\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.usp.br\/rnpavc\/wp-json\/wp\/v2\/users\/906"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.usp.br\/rnpavc\/wp-json\/wp\/v2\/comments?post=840"}],"version-history":[{"count":4,"href":"https:\/\/sites.usp.br\/rnpavc\/wp-json\/wp\/v2\/pages\/840\/revisions"}],"predecessor-version":[{"id":985,"href":"https:\/\/sites.usp.br\/rnpavc\/wp-json\/wp\/v2\/pages\/840\/revisions\/985"}],"wp:attachment":[{"href":"https:\/\/sites.usp.br\/rnpavc\/wp-json\/wp\/v2\/media?parent=840"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}