Laboratório de Farmacogenômica

Our studies have resulted in a large number of research articles and reviews and have significantly affected our research field.

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  • da Paixão AO, Bolin AP, Silvestre JG, Rodrigues AC. Palmitic Acid Impairs Myogenesis and Alters Temporal Expression of miR-133a and miR-206 in C2C12 Myoblasts. Int. J. Mol. Sci. 2021, 22(5), 2748. https://doi.org/10.3390/ijms22052748 
  • Masi LN, Lotufo PA, Ferreira FM, Rodrigues AC, Serdan TDA, Souza-Siqueira T, Braga AA, Saldarriaga MEG, Alba-Loureiro TC, Borges FT, Cury DP, Hirata MH, Gorjão R, Pithon-Curi TC, Lottenberg SA, Fedeli LMG, Nakaya HTI, Bensenor IJM, Curi R, Hirabara SM. Profiling plasma-extracellular vesicle proteins and microRNAs in diabetes onset in middle-aged male participants in the ELSA-Brasil study. Physiol Rep. 2021. PMID: 33587339; PMCID: PMC7883809. https://doi.org/10.14814/phy2.14731 
  • de Mendonça M, Rocha KC, de Sousa É, Pereira BMV, Oyama LM, Rodrigues AC. Aerobic exercise training regulates serum extracellular vesicle miRNAs linked to obesity to promote their beneficial effects in mice. Am J Physiol Endocrinol Metab. 2020. PMID: 32744099. https://doi.org/10.1152/ajpendo.00172.2020 
  • de Oliveira Silva T, Lino CA, Buzatto VC, Asprino PF, Lu YW, Lima VM, Fonseca RIB, Jensen L, Murata GM, Filho SV, Ribeiro MAC, Donato JJ, Ferreira JCB, Rodrigues AC, Irigoyen MC, Barreto-Chaves MLM, Huang ZP, Galante PAF, Wang DZ, Diniz GP. Deletion of miRNA-22 Induces Cardiac Hypertrophy in Females but Attenuates Obesogenic Diet-Mediated Metabolic Disorders.Cell Physiol Biochem. 2020 54(6):1199-1217. PMID: 33252886. https://doi.org/10.33594/000000309 
  • Frias F de T, de Mendonça M, Martins AR, Gindro AF, Cogliati B, Curi R, Rodrigues AC. MyomiRs as Markers of Insulin Resistance and Decreased Myogenesis in Skeletal Muscle of Diet-Induced Obese Mice. Front Endocrinol (Lausanne). 2016 7:76. PMID: 27445979; PMCID: PMC4921801. https://doi.org/10.3389/fendo.2016.00076 
  • MENDONCA, M.; SOUSA, E.; PAIXAO, A. O.; SANTOS, B. A. C.; SPAGNOL, A. R.; MURATA, G. M.; ARAUJO, HYGOR N.; LIMA, TANES I.; GUIMARAES, D. S.; SILVEIRA, L. R.; RODRIGUES, A.C. MicroRNA miR-222 mediates pioglitazone beneficial effects on skeletal muscle of diet-induced obese mice. MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2019. (accepted) https://doi.org/10.1016/j.mce.2019.110661 
  • MENDONCA, M.; SANTOS, B. A. C.; SOUSA, E.; RODRIGUES, A.C. Adiponectin is required for pioglitazone-induced improvements in hepatic steatosis in mice fed a high-fat diet. MOLECULAR AND CELLULAR ENDOCRINOLOGY, v. 493, p. 110480, 2019. https://doi.org/10.1016/j.mce.2019.110480 
  • FRIAS, F. T.; ROCHA, K. C. E.; MENDONCA, M.; MURATA, G. M.; ARAUJO, HYGOR N.; SOUSA, L. G. O.; SOUSA, E.; Hirabara, S. M.; CARVALHO, N.; CARNEIRO, EVERARDO M.; CURI, R.; SILVEIRA, LEONARDO R.; RODRIGUES, A.C. Fenofibrate reverses changes induced by high-fat diet on metabolism in mice muscle and visceral adipocytes. JOURNAL OF CELLULAR PHYSIOLOGY, v. 233, p. 3515-3528, 2018. https://doi.org/10.1002/jcp.26203 
  • RODRIGUES, A. C.; NERI, E. A.; VERISSIMO FILHO, S.; HIRATA, R. D. C.; Yu, A.M. Atorvastatin attenuation of ABCB1 expression is mediated by microRNA miR-491-3p in Caco-2 cells. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, v. 93, p. 431-436, 2016. https://doi.org/10.1016/j.ejps.2016.08.044 
  • RODRIGUES, A. C.; Li, Xin; Radecki, Laura; Pan, Yu-Zhuo; Winter, Jerrold C.; Huang, Min; Yu, Ai-Ming. MicroRNA expression is differentially altered by xenobiotic drugs in different human cell lines. Biopharmaceutics & Drug Disposition, v. 32, p. 355-367, 2011. https://doi.org/10.1002/bdd.764