Chemistry, UFSCar – Federal University of São Carlos, 2024
Guilherme B. Simoso completed his graduation in Chemistry in 2024 at UFSCar, Brazil, under the supervision of Prof. Dr. Kleber T. de Oliveira and co-supervision of Dr. Guilherme M. Martins, with a focus on the electrosynthesis of small molecules and biologically active nuclei. In 2018, he obtained a technical diploma in Chemistry from the Federal Institute of São Paulo – IFSP.
He is currently studying for a Master’s degree at the University of São Paulo – USP, supervised by Prof. Dr. Giuliano C. Clososki, focusing on the synthesis of biologically active fragments and their functionalization through metallation reactions.
Project title: Development of synthetic methodologies for the synthesis and vector functionalization of 5,8-dihydro-1,6-naphthyridin-7(6H)-one: FBDD approach.
The Fragment-Based Drug Discovery (FBDD) strategy has become prominent in the development of new bioactive molecules, as it allows for the rational construction of compounds from low molecular weight fragments. In this context, this project aims to develop synthetic methodologies for the vector functionalization of a fragment, exploring regioselective metallation reactions.
In addition, in order to optimize the efficiency of the process, reduce the environmental impact and make production on a larger scale more viable, innovative strategies such as continuous flow synthesis, electrosynthesis and photocatalysis will be considered.