Artigos

SILVA, A.B.; DOS SANTOS, N.A.P.; BERTOLONI, R.R.; OLIVEIRA-FILHO, A.G.S.; NIKOLAOU, S. CO release by redox stimuli and HSA interaction: Planning new CORMs based on µ-oxo triruthenium carbonyl clusters. Polyhedron, 278, 117589, 2025.

 

BARBOSA, H.E.; SILVA, A.B.; NAZAR, P.H.O.; BERTOLONI, R.R.; OLIVEIRA-FILHO, A.G.S.; NIKOLAOU, S. Reactivity of trinuclear ruthenium acetates with nitrite and nitric oxide ligands in aqueous media. Dalton Transactions, 54, 9388-9398, 2025.

 

NIKOLAOU, S.; CHAVES, O.A.; BERTOLONI, R.R.; IGLESIAS, B.A. Investigation on the Interaction Between μ-oxo Trinuclear Ruthenium Complexes and DNA. Revista Virtual de Química, 17, 513-521, 2025.

 

OLIVEIRA, M.M.; DINIZ, C.C.; COSTA, L.A.S.; DOS SANTOS, N.A.P.; NIKOLAOU, S.; MOREIRA, M.P.; DE OLIVEIRA, T.E.; IGLESIAS, B.A. Mono-substituted corroles containing morpholinyl, piperidyl and pyrrolidinyl units: Photophysics, photobiology and biomolecular interaction studies. Journal of Molecular Liquids, 435, 128168, 2025.

MÜLLER, A.V.; WIERZBA, W.M.; DO NASCIMENTO, L.G.A.; CONCEPCION, J.J.; NIKOLAOU, S.; POLYANSKY, D.E.; POLO, A.S. Tuning the Photocatalytic CO2 Reduction through para -Substituents in Bipyridyl Rhenium Complexes. Artificial Photosynthesis, 01, 214-225, 2025.

 

PINHEIRO, B.F.A.; FERNANDES, N.C.; CHAVES, O.A.; ELLENA, J.A.; QUEIROZ, M.S.; TEDESCO, A.C.; ARAUJO-NETO, J.H.; NIKOLAOU, S. Water-soluble µ-oxo triruthenium compound of biological interest: H-bonds network and interaction with HSA. European Journal of Inorganic Chemistry, 27, e202300617, 2024.

 

BATISTA, A.P.L.; PAVAN, J.R.; RIBEIRO, M.A.; NIKOLAOU, S.. Unveiling the Electronic and Molecular Structure of a Trinuclear Ruthenium Cluster Containing One Nitrosyl Ligand. Journal of Molecular Structure, 1308, 138119, 2024.

 

DO NASCIMENTO, L.G.A.; BARBETTA, M.F.; CHAVES, O.A.; DE OLIVEIRA, A.R.M.; NIKOLAOU, S.. Interaction of a triruthenium ortho-metallated phenazine with cytochrome P450 enzymes. Journal of The Brazilian Chemical Society, 35, e-20240136, 2024.

 

NIKOLAOU, S.; DO NASCIMENTO, L.G.A.; ALEXIOU, A.D.P. Oxo-centered trinuclear ruthenium acetates: Structure and applications. Coordination Chemistry Reviews, 494, 215341, 2023.

 

IGLESIAS, B.A.; PERANZONI, N.P.; FARIA, S.I.; TRENTIN, L.B.; SCHUCH, A.P.; CHAVES, O.A.; BERTOLINI, R.R.; NIKOLAOU, S.; DE OLIVEIRA, KLEBER THIAGO. DNA-Interactive and Damage Study with meso-Tetra(2-thienyl)porphyrins Coordinated with Polypyridyl Pd(II) and Pt(II) Complexes. Molecules, 8, 52172023, 2023.

 

CACITA, N.; SILVA, A.B.; DOS SANTOS, N.A.P.; RAMOS, L.C.B.; DEL LAMA, M.P.F.M.; NAAL, R.M.Z.G.; NIKOLAOU, S. Interactions with HSA, anticancer and antiallergic activity of binuclear μ-oxo bridged ruthenium acetate compounds. Chemistryselect, 8, e202300285, 2023.

 

MATEUS, D.B.G.; BATISTA, A.P.L.; SOUZA, S.S.; DEMETS, G.J.-F.; NIKOLAOU, S.. Solvatochromism and solution π-stacking of N-(4-pyridyl)-1,8-naphthalimide and its corresponding triruthenium coordination complex. Spectrochimica Acta Part A-Molecular and Biomolecular Spectroscopy, 292, 122420-0, 2023.

 

SARMENTO, C.O.; PINHEIRO, B.F.A.; ABRAHÃO, J.; CHAVES, O.A.; MOREIRA, M.B.; NIKOLAOU, S. Interactions of a Ruthenium-Ketoprofen Compound with Human Serum Albumin and DNA: Insights from Spectrophotometric Titrations and Molecular Docking Calculations. ChemistrySelect, v. 7, 2022.

 

DOS SANTOS, N.A.P.; SILVA, A.B.; DA SILVA, C.F.N.; ALEXIOU, A.D.P.; NIKOLAOU, S. A novel triruthenium nitrosyl bearing a quinolinic ligand: a comparison of its spectroscopic behavior with its pyridine analogues. New Journal of Chemistry, 46, 4819-4826, 2022.

 

DA SILVA, C.F.N.; DE ALMEIDA, E.T.; NIKOLAOU, S.; ALEXIOU, A.D.P.. Probing the thermal stability of μ-oxo triruthenium clusters. Polyhedron, 198, 115051, 2021.

 

PEREZ, N.M.; HIGASHIJIMA, G.Y.; RAMOS, V.M.; BATISTA, A.P.L.; NIKOLAOU, S.. Probing solvents effects on the absorption spectrum of oxo-centered carbonyl-triruthenium clusters. Polyhedron, 194, 114944, 2021.

 

DA SILVA, C.F.N.; CHRISPIM, P.B.H.; POSSATO, B.; PORTAPILLA, G.B.; ROHRABAUGH, T.N.; RAMOS, L.C.B.; DA SILVA, R.S.; ALBUQUERQUE, S.; TURRO, C.; NIKOLAOU, S. Anticancer and antitrypanosomal activities of trinuclear ruthenium compounds with orthometalated phenazine ligands. Dalton Transactions, 49, 16440-16452, 2020.

 

MATEUS, D.B.G.; BATISTA, A.P.L.; RODRIGUES, R.L.; NIKOLAOU, S. NO Photorelease from a Ruthenium Complex Assisted by Formation of a Supramolecular Dimer. Journal of the Brazilian Chemical Society, 31, 2319-2330, 2020.

 

MATEUS, D.B.G.; SOUZA, S.S.; SILVA, R.J.B.; BATISTA, A.P.L.; CICOLANI, R.S.; MURIE, V.E.; NISHIMURA, R.H.; CLOSOSKI, G.C.; OLIVEIRA-FILHO, A.G.S.; DEMETS, G.J.-F.; NIKOLAOU, S.. Assessment of the electronic structure of a triruthenium acetate-pyridylnaphthalimide cluster. Journal of Photochemistry and Photobiology A: Chemistry, 391, 112361, 2020.

 

POSSATO, B.; CHRISPIM, P.B.H.; ALVES, J.Q.; RAMOS, L.C.B.; MARQUES, E.; DE OLIVEIRA, A.C.; DA SILVA, R.S.; FORMIGA, A.L.B.; NIKOLAOU, S. Anticancer activity and DNA interaction of ruthenium acetate clusters bearing azanaphthalene ancillary ligands. Polyhedron, 176, 114261, 2020.

 

DA SILVA, C.F.N. ; RAMOS, L.C.B.; ROHRABAUGH, T.N.; VANDERVORD, J.; DA SILVA, R.S.; TURRO, C.; NIKOLAOU, S. Exploring the structure of a ruthenium acetate cluster for biological purposes. Inorganic Chemistry Communications, 114, 107810, 2020.

 

DA SILVA, C.F.N.; AL-AFYOUNI, M.; XUE, C.; FERREIRA, F.H.C.; COSTA, L.A.S. ; TURRO, C.; NIKOLAOU, S. Syntheses and electronic, electrochemical, and theoretical studies of a series of μ-oxo-triruthenium carboxylates bearing orthometalated phenazines. Dalton Transactions, 49, 1688-1698, 2020.

 

DA SILVA, C.F.N.; POSSATO, B.; FRANCO, L.P.; RAMOS, L.C.B.; NIKOLAOU, S. The role of ancillary ligand substituents in the biological activity of triruthenium-NO complexes. Journal of Inorganic Biochemistry, 186, 197-205, 2018.

 

NIKOLAOU, S; DA SILVA, C.F.N. Considerações sobre textos que tratam do desenvolvimento de metalofármacos de rutênio. Química Nova, 41, 833-838, 2018.

 

VAIDERGORN, M.M.; CARNEIRO, Z.A.; REIS, F.C.C.; LOPES, C.D.; MELLO, J.F.; GENESI, G.L.; TROSSINI, G.H.G.; NIKOLAOU, S.; ALBUQUERQUE, S.; GANESAN, A.; EMERY, F.S. β-amino alcohols and their respective 2-phenyl-N-alkyl aziridines as potential DNA minor groove binders. European Journal of Medicinal Chemistry, 157, 657-664, 2018.

 

POSSATO, B.; DEFLON, V.M.; NAAL, Z.; FORMIGA, A.L.B.; NIKOLAOU, S. An extended π-system and enhanced electronic delocalization on symmetric [Ru3O(CH3COO)6(L)3]n complexes combined with azanaphthalene ligands. Dalton Transactions, 46, 7926-7938, 2017.

 

POSSATO, B.; CARNEIRO, Z.A.; DE ALBUQUERQUE, S.; NIKOLAOU, S. The very first report on the trypanocidal activity of symmetric trinuclear ruthenium complexes. Journal of Inorganic Biochemistry, 176, 156-158, 2017.

 

CACITA, N.; NIKOLAOU, S. Studying the interaction between trinuclear ruthenium complexes and human serum albumin by means of fluorescence quenching. Journal of Luminescence, 169, 115-120, 2016.

 

REIS, F.C.C.; COELHO, J.S.V.; PAZIN, W.M.; NIKOLAOU, S. A new homoleptic coordination compound of ruthenium and norfloxacin and its interaction with human serum albumin. Inorganic Chemistry Communications, 63, 96-100, 2016.

 

DE OLIVEIRA, R.S.; BOFFO, E.F.; REIS, F.C.C.; NIKOLAOU, S; ANDRIANI, K.F.; CARAMORI, G.F.; DORO, F.G. A ruthenium polypyridyl complex with the antihypertensive drug valsartan: Synthesis, theoretical calculations and interaction studies with human serum albumin. Polyhedron, 114, 232-241, 2016.

 

MOREIRA, M.B.; DA SILVA, C.F.N.; PESCI, R.; DEFLON, V.; NIKOLAOU, S. Revisiting oxo-centered carbonyl-triruthenium clusters: investigating CO photorelease and some spectroscopic and electrochemical correlations. Dalton Transactions, 45, 16799-16809, 2016.

 

CACITA, N.; POSSATO, B.; DA SILVA, C.F.N.; PAULO, M.; FORMIGA, A.L.B.; BENDHACK, L.M.; NIKOLAOU, S. Investigation of a novel trinuclear μ-oxo ruthenium complex as a potential nitric oxide releaser for biological purposes. Inorganica Chimica Acta, 429, 114-121, 2015.

 

SEUANES, G.C.; MOREIRA, M.B.; PETTA, T.; DEL LAMA, M.P.F.M.; DE MORAES, L.A.B.; DE OLIVEIRA, A.R.M.; NAAL, NAAL, R.M.Z.G.; NIKOLAOU, S . Novel binuclear μ-oxo diruthenium complexes combined with ibuprofen and ketoprofen: Interaction with relevant target biomolecules and anti-allergic potential. Journal of Inorganic Biochemistry, 153, 178-185, 2015.

 

CARNEIRO, Z.A.; MORAES, J.C.B.; ALEXIOU, A.D.P.; NIKOLAOU, S. Nitric oxide photorelease from a trinuclear ruthenium nitrosyl complex and its in vitro cytotoxicity against melanoma cells. Journal of Inorganic Biochemistry, 36-38, 2014.

CARDOSO, F.P.; NETO, S.A.; CREPALDI, L.B.; NIKOLAOU, S.; BARROS, V.P.; ANDRADE, A.R. Biocathodes for Enzymatic Biofuel Cells Using Laccase and Different Redox Mediators Entrapped in Polypyrrole Matrix. Journal of the Electrochemical Society, 161, F445-F450, 2014.

 

VIDAL, R.S.; DORO, F.G.; FERREIRA, K.Q.; DA ROCHA, Z.N.; CASTELLANO, E.E.; NIKOLAOU, S.; TFOUNI, E. Cis trans isomerization in the syntheses of ruthenium cyclam complexes with nitric oxide. Inorganic Chemistry Communications, 15, 93-96, 2012.

 

TANIMOTO, M.K.; DIAS, K.; DOVIDAUSKAS, S.; NIKOLAOU, S. Tuning the reaction products of ruthenium and ciprofloxacin for studies of DNA interactions. Journal of Coordination Chemistry, 65, 1504-1517, 2012.

 

TOMA, S.H.; SANTOS, J.J.; NIKOLAOU, S.; ARAKI, K.; TOMA, H.E.  Direct Assembly of a Metallodendrimer Encompassing Seven Triruthenium Clusters Units. Inorganica Chimica Acta, 390, 148-153, 2012.

 

DIAS, K.; NIKOLAOU, S.; GIOVANI, W.F. The in vitro antioxidant properties of the Al-quercetin/ßCD and Al-catechin/ßCD inclusion compounds, rationalized in terms of their electrochemical behaviour. Medicinal Chemistry Research, 21, 2920-2925, 2012.

 

DE CARVALHO, A.N.; FORNARI, E.C.; GOMES, W.R.; ARAÚJO, D.M.S.; MACHADO, A.E.H.; NIKOLAOU, S. The bimolecular sensitization of nitric oxide release from weak interacting ruthenium units. Inorganica Chimica Acta, 444-448, 2011.

 

NIKOLAOU, S.; TOMA, S.H.; SOUZA, V.R.; BONACIN, J.A.; ARAKI, K.; TOMA, H.E. Triangular ruthenium acetate clusters containing the bis(pyridyl)propane ligand and their inclusion chemistry with ß-cyclodextrin. Transition Metal Chemistry, 36, 775-783, 2011.

 

DIAS, K.; NIKOLAOU, S. Does the Combination of Resveratrol with Al (III) and Zn (II) Improve its Antioxidant Activity?. Natural Product Communications, 6, 1934578X1100601, 2011.

 

NIKOLAOU, S.; FORMIGA, A.L.B.; TOMA, H.E. Probing the electronic delocalization in a cyclic pyrazine ruthenium cluster hexamer. Inorganic Chemistry Communications, 13, 1032-1035, 2010.

 

MOREIRA, E.Z.; FERREIRA, A.D.Q.; NERI, C.R.; MUKHOPADHYAY, S.; DOVIDAUSKAS, S.; NIKOLAOU, S.; IAMAMOTO, Y. Syntheses, electrochemistry and photophysical properties of a series of meso-pyridylpentafluorophenylporphyrins. Journal of Porphyrins and Phthalocyanines, 14, 975, 2010.

 

FORNARI, E.C.; MARCHESI, M.S.P.; MACHADO, A.E.H.; NIKOLAOU, S. Exploring weak interactions to assemble a nitrosyl–ruthenium compound able to release NO under visible light irradiation. Polyhedron, 1121-1126, 2009.

 

DE OLIVEIRA, A.R.M.; OLIVEIRA, F.M.; DE SANTANA, D.C.A.S.; NIKOLAOU, S.; BONATO, P.S.; DA SILVA, R.S. HPLC separation, NMR and QTOF/MS/MS structure elucidation of a prominent nitric oxide donor agent based on an isomeric composition of a nitrosyl ruthenium complex. Inorganic Chemistry Communications, 12, 343-346, 2009.

 

NIKOLAOU, S.; TOMA, H.E. A convergent approach for the generation of dendrimers containing the [Ru3O(CH3COO)6] electroactive core. European Journal of Inorganic Chemistry, 14, 2266-2271, 2008.

 

DIAS, K.; NIKOLAOU, S.; GIOVANI, W.F. Synthesis and Spectral Investigation of Al(III) Catechin/beta-Cyclodextrin and Al(III) Quercetin/beta-Cyclodextrin Inclusion Compounds. Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy, 70, 154-161, 2008.

 

MOREIRA, E.Z.; MORAES, L.AB.; EBERLIN, M.N.; IAMAMOTO, Y.; NIKOLAOU, S. The use of electrospray ionization tandem mass spectrometry on the structural characterization of novel asymmetric metallo-organic supermolecules, based on pentafluorophenylporphyrins and ruthenium complexes. Polyhedron, 27, 2721-2729, 2008.

 

NIKOLAOU, S.; TOMAZELA, D.M.; EBERLIN, M.N.; TOMA, H.E.  Synthesis and characterization of the [Ru3O(CH3COO)6(py)2(BPE)Ru(bpy)2Cl](PF6)2 dimer. Transition Metal Chemistry, 33, 1059-1065, 2008.

 

GUZZO, M.R.; UEMI, M.; DONATE, P.M.; NIKOLAOU, S.; MACHADO, A.E.H.; OKANO, L.T. Study of the complexation of fisetin with cyclodextrins. The Journal of Physical Chemistry. A, 110, 10545-10551, 2006.

 

EBERLIN, M.N.; TOMAZELA, D.M.; ARAKI, K.; ALEXIOU, A.D.P.; FORMIGA, A.L.B.; TOMA, H.E.; NIKOLAOU, S. Electrospray Ionization Tandem Mass Spectrometry of Polymetallic μ-Oxo- and Carboxylate-Bridged [Ru3O(CH3COO)6(Py)2(L)]+ Complexes:  Intrinsic Ligand (L) Affinities with Direct Access to Steric Effects, 25, 3245-3250, 2006.

 

FERREIRA, K.Q.; CARDOSO, L.N.; NIKOLAOU, S.; ROCHA, Z.N.; DA SILVA, R.S.; TFOUNI, E. Solvent Dependent Conformational Isomerism and Ligand Oxidation of Novel Ru(II) Cyclen Complexes. Inorganic Chemistry, 44, 5544-5546, 2005.

 

TOMA, S.H.; NIKOLAOU, S.; TOMAZELA, D.M.; EBERLIN, M.N.; TOMA, H.E. Synthesis, Spectroscopy, Tandem Mass Spectrometry, and Electrochemistry of the Linearly Bridged trans-1,4-bis[2-(4-pyridyl)ethenyl]-benzene}-{Ru3O(CH3COO)6(py)2}2 Cluster. Inorganica Chimica Acta, 357, 2253-2260, 2004.

 

TOMA, H.E.; ARAKI, K.; ALEXIOU, A.D.P.; NIKOLAOU, S.; DOVIDAUSKAS, S. Monomeric and extended oxo-centered triruthenium clusters. Coordination Chemistry Reviews, 219-221, 187-234, 2001.

 

NIKOLAOU, S.; TOMA, H.E. Self-assembly of a supramolecular cyclic polymer containing pyrazine bridged trinuclear μ-oxo-ruthenium-acetate clusters. Journal of Chemical Research, 2000, 326-327, 2000.

 

TOMA, H.E.; ALEXIOU, A.D.P.; NIKOLAOU, S.; DOVIDAUSKAS, S. 13C NMR spectra of triangular μ‐oxoruthenium acetate clusters revisited: HETCOR study of two pyridine and 4,4′‐bipyridine derivative. Magnetic Resonance in Chemistry, 37, 322-324, 1999.

 

ARAUJO, J.; NIKOLAOU, S.; ALEXIOU, A.D.P.; TOMA, H.E. Synthesis of a trinuclear ruthenium cluster containing pyridine and 4-acetylpyridine ligands and its immobilization on functionalized silica. Monatshefte für Chemie, 128, 759-766, 1997.