O novo artigo-review “Allosteric Modulators of Potential Targets Related to Alzheimer’s Disease: a Review” foi aceito e já está disponível online.
Em 16/07/2019 foi aceito e publicado online o mais novo artigo de review escrito pelos membros do LCQF.
O artigo de review contou com a participação de Guilherme, Mariana, João, Lorane e Prof. Carlos e foi publicado após uma extensa e minuciosa revisão sobre o tema.
Este foi publicado na revista ChemMedChem, da editora Wiley Online Library.
Confira o abstract:
Among the neurodegenerative disorders, Alzheimer’s disease (AD) represents the most common type of dementia and there is an urgent need to discover new and efficacious forms of treatment for it. Pathological patterns of AD include cholinergic dysfunction, increase in β‐amyloid (Aβ) peptide concentration, appearance of neurofibrillary tangles, and others, all of them strongly associated with specific biological targets. Interactions observed between these targets and potential drug candidates in AD, most often occur by competitive mechanisms driven by orthosteric ligands that sometimes result in the production of side effects. In this context, the allosteric mechanism represents a key strategy, which can be translated as selective modulation of such targets by allosteric modulators in an advantageous manner, since this may provide lower chances of causing side effects. The purpose of this review is to present an overview of compounds that act as allosteric modulators of main biological targets related to AD.
Ref.: https://onlinelibrary.wiley.com/doi/abs/10.1002/cmdc.201900299
