Welcome to the Biology of Digestive Epithelia Laboratory website!

Instituto de Ciências Biomédicas - USP

The gastrointestinal tract epithelium is continually renewed and this process is controlled by several factors, such as food, hormones, growth factors and innervation. We used several approaches to assess the complex interaction between these elements and their effect on epithelial cell kinetics during the development of the gastric and intestinal mucosa. At the beginning of postnatal development, breastfeeding acts as an important route in controlling growth and maturation of the gastrointestinal tract. Thus we aim to study the effect of some hormones and growth factors present in milk on cell kinetics, using mainly immunohistochemical/cytochemical techniques.

Figure at right: Immunofluorecence for the identification of proliferative cells in the gastric mucosa of rats 30 days post birth. Ki-67 identified with AlexaFluor®-563 (red). Nuclei were stained with DAPI (blue). Original magnification: 400x

Goblet cells in the small intestine identified by histochemical reaction with PAS-AB. Original magnification: 400x

Double stained immunofluorescence to positive Troy cells identified by AlexaFluor®-633 (red) and parietal cells, AlexaFluor®-488 (green) in 60-day-old rats. Nuceli stained with DAPI (blue). Original magnification: 200x

Join us!

If you are interested in joining the group, please contact me by e-mail with your updated CV and a motivation letter explaining your research interests. Please, if possible, include the contact of researchers you had previously worked with.


Biology of Digestive Epithelia Laboratory

Av. Prof. Lineu Prestes, 1524
São Paulo - SP, Brazil

+55 (11) 3091-7303