Programa – Orientadores e Linhas de Pesquisa – Bárbara Falquetto

Bárbara Falquetto

Professora Doutora

Laboratório

Mecanismos Neuromoleculares no Controle cardiorrespiratório – sala 332

Lattes

http://lattes.cnpq.br/2832392875866139

Contato

Telefone: (11) 3091-7318 / (11) 3091-7285
Email: barbaraf@icb.usp.br

LINHA DE PESQUISA

Linha de pesquisa: Mecanismos Neuromoleculares no Controle cardiorrespiratório

Descrição: O controle neural cardiorrespiratório se dá por uma rede de neurônios na região do tronco encefálico que orquestram sinalizações a fim de manter a homeostasia. Em patologias, como as doenças neurodegenerativas, este controle sofre intensa disfunção anatomofuncional. Minha linha de pesquisa busca pavimentar novas avenidas no entendimento dos fenômenos complexos geradores do desbalanço entre o dano e reparação celular atuando na investigação de mecanismos neurais e de sinalização intracelular nos núcleos de controle neural cardiorrespiratório.

Principais trabalhos desenvolvidos

Purinergic receptors blockade in the retrotrapezoid nucleus attenuates the respiratory chemoreflexes in awake rats

Barna, BF; Takakura, AC; Mulkey, DK; Moreira, TS. Purinergic receptors blockade in the retrotrapezoid nucleus attenuates the respiratory chemoreflexes in awake rats. Acta Physiol (Oxf). 2016

Inhibition of the hypercapnic ventilatory response by adenosine in the retrotrapezoid nucleus in awake rats

Falquetto B, Oliveira LM, Takakura AC, Mulkey DK, Moreira TS. Inhibition of the hypercapnic ventilatory response by adenosine in the retrotrapezoid nucleus in awake rats. Neuropharmacology. 2018

Attenuated baroreflex in a Parkinson's disease animal model coincides with impaired activation of non-C1 neurons

Cabral LM, Moreira TS, Takakura AC, Falquetto B. Attenuated baroreflex in a Parkinson’s disease animal model coincides with impaired activation of non-C1 neurons. Auton Neurosci. 2020

Oxidative stress in the medullary respiratory neurons contributes to respiratory dysfunction in the 6-OHDA model of Parkinson's disease

Falquetto B, Thieme K, Malta MB, E Rocha KC, Tuppy M, Potje SR, Antoniali C, Rodrigues AC, Munhoz CD, Moreira TS, Takakura AC. Oxidative stress in the medullary respiratory neurons contributes to respiratory dysfunction in the 6-OHDA model of Parkinson’s disease. J Physiol. 2020

Oxidative stress inhibition via apocynin prevents medullary respiratory neurodegeneration and respiratory pattern dysfunction in a 6-OHDA animal model of Parkinson's disease

Nascimento ALF, Medeiros POS, Pedrão LFAT, Queiroz VC, Oliveira LM, Novaes LS, Caetano AL, Munhoz CD, Takakura AC, Falquetto B. Oxidative stress inhibition via apocynin prevents medullary respiratory neurodegeneration and respiratory pattern dysfunction in a 6-OHDA animal model of Parkinson’s disease. Neuroscience. 2022