Leticia Veras Costa Lotufo
Full Professor
Laboratory
Laboratory of Marine Neuropharmacology Research – lab 213
Research interests
Research interests: Marine Natural Products Pharmacology
Description: The research line focuses on a combination of marine natural product discovery with molecular and cellular biology to identify new anticancer leads.
Main works developed
Trzoss, L.; Fukuda,T; Costa-Lotufo, L.V.; Jimenez, P.; La Clair, J.J.; Fenical, W. Seriniquinone, a selective anticancer agent, induces cell death by autophagocytosis, targeting the cancer protective protein dermcidin. Proccedings of The National Academy of Science USA, v. 111, p. 14687-14692, 2014
Guimarães, L. A.; Jimenez, P.J. ; Sousa, T.S. ; Freitas, H.P.S.; Rocha, D.D. ; Wilke, D.V. ; Martín, J.; Reyes, F.; Pessoa, O.D.L.; Costa-Lotufo, L.V. Chromomycin A2 Induces Autophagy in Melanoma Cells. Marine Drugs, v. 12, p. 5839-5855, 2014
Abreu, P.A.; Sousa, T.S. Jimenez, P.C. ; Wilke, D.V. ; Rocha, D.D. ; Freitas, H.P. S.; Pessoa, O.D.L.; La Clair, J.J.; Costa-Lotufo, L.V. Identification of Pyrroloformamide as a Cytokinesis Modulator. ChemBioChem (Print), v. 15, p. 501-506, 2014
Wijeratne EM, Xu YM, Scherz-Shouval R, Marron MT, Rocha DD, Liu MX, Costa-Lotufo LV, Santagata S, Lindquist S, Whitesell L, Gunatilaka AA. Structure-Activity Relationships for Withanolides as Inducers of the Cellular Heat-Shock Response. J Med Chem. 57: 2851-2863, 2014
Jimenez, P.C.; Wilke, D.V.; Ferreira, E.G.; Takeara, R.; Moraes, M.O.; Silveira, E.R.; Lotufo, T.M.C.; Lopes, N.P.; Costa-Lotufo, L.V. Structure Elucidation and Anticancer Activity of 7-Oxostaurosporine Derivatives from the Brazilian Endemic Tunicate Eudistoma vannamei. Marine Drugs, 10: 1092-1102, 2012