Diego Antonio Falceta Gonçalves (dfalceta@usp.br)
Eutimio Gustavo Fernández Núñez (egfnunez@usp.br)
Felipe Santiago Chambergo Alcalde (fscha@usp.br)
Grzegorz Kowal (grzegorz.kowal@usp.br)
Patrícia Targon Campana (pcampana@usp.br)
Tânia Araújo Viel (taniaviel@usp.br)
Viviane Abreu Nunes Cerqueira Dantas (vanunes@ib.usp.br)
6 credits (9ECTS): 4 (theoretical classes) + 2 (field trip)
Lecture schedule
Tuesday, 14:00-18:00 h - Building I1 – Room: 135
Course description
The course will provide an overview of advanced topics of several sciences such as computing science, fluid biophysics, cell therapy and tissue bioengineering, neuroscience and bioprocess engineering, which represent important fields of interface and interaction opportunities with Biotechnology. The knowledge built in this discipline should favor the performance in the area of Biotechnology, opening perspectives for the student to identify potential applications of the topics dealt with in situations of professional practice and with the development of products and services of biotechnological interest.
Program
THEORETICAL PART
Brazilian Biodiversity
Pharmaceutics and Tissue bioengineering
- Nanomaterials
- Stem cells and cell therapy
- Biomaterials and 3D cultures
Neuroscience
- Neurotransmission, synapses and neuroplasticity
- Central nervous system modeling for the study of brain aging and neurodegenerative diseases
Fluid Biophysics
- Basics of fluid dynamics
- Applications to the cardiovascular system
- Air dynamics and respiration
Data Science
- Data mining
- Bioinformatics
- Modeling of complex systems
Bioprocess engineering
- Principles of the upstream and downstream stages for manufacturing biomolecules holding commercial interest
- Experimentation throughout the development stages of a bioprocess
- Economic assessment of technological alternatives
PRACTICAL PART (FIELD TRIP)
Analysis of problems in complex situations of the Brazilian reality in excursions to critical regions that allow highlighting crucial demands of the contemporary world.
Evaluation
Students will be evaluated on the basis of a 20 min oral presentation (previously prepared either individually or in a group) on a topic chosen by the student themselves. The following criteria will be considered in the assessment: clarity of presentation, organization of content, amplitude and precision of notions
Attendance and Participation
Attendance is mandatory in 70% of the activities.
Grading and approval criteria
Grade equal to or greater than 5.0: student approved;
Grade between 3.0 and 4.9: requires a 2nd evaluation step (test to be taken in January);
Grade below 3.0: failure.
References
Tissue bioengineering
- Nourian Dehkordi, A. et al. Skin tissue engineering: wound healing based on stem-cell-based therapeutic strategies. Stem Cell Res Ther, v. 10, n. 1, p. 111, 2019.
- Chua, A. W. et al. Skin tissue engineering advances in severe burns: review and therapeutic applications. Burns Trauma, v. 19, n. 4, p. 3, 2016.
- Yi, S. et al. (2016). Extracellular Matrix Scaffolds for Tissue Engineering and Regenerative Medicine. Curr Stem Cell Res Ther.2016 Sep 4.[Epub ahead of print].
- Muzzio, N., Moya, S., Romero, G. Multifunctional scaffolds and synergistic strategies in tissue engineering and regenerative medicine. v. 13, n. 6, 2021. DOI: 10.3390/pharmaceutics13060792.
- Di Marzio, N., Eglin, D., Serra, T., et al. Bio-Fabrication: Convergence of 3D Bioprinting and Nano-Biomaterials in Tissue Engineering and Regenerative Medicine. Frontiers in Bioengineering and Biotechnology. v. 8, n. April, 2020. DOI: 10.3389/fbioe.2020.00326.
- Lin, K., Zhang, D., Macedo, M. H., et al. Advanced Collagen-Based Biomaterials for Regenerative Biomedicine. Advanced Functional Materials v. 29, n. 3, 2019. DOI: 10.1002/adfm.201804943.
- Hernandez, E. D. D., Reyes-Romero, J. R. Materials for Biomedical Engineering Thermoset and Thermoplastic Polymer, Chapter 14: Characteristics of polymeric materials used in medicine. [S.l.], Elsevier Inc., 2019. v. 1. Disponível em: http://dx.doi.org/10.1016/B978-0-12-816874-5.00014-1.
- Yilmaz, B., Al Rashid, A., Mou, Y. A., et al. Bioprinting: A review of processes, materials and applications. v. 23, n. April, p. e00148, 2021. DOI: 10.1016/j.bprint.2021.e00148. Disponível em: https://doi.org/10.1016/j.bprint.2021.e00148.
- Steffens, D. et al. Development of a biomaterial associated with mesenchymal stem cells and keratinocytes for use as a skin substitute. Regen Med, v. 10, n. 8, p. 975-987, 2015.
- Xie, S.Y. et al. Adult stem cells Seeded on electrospinning silk fibroin nanofibrous scaffold enhance wound repair and regeneration. J Nanosci Nanotechnol, v. 16, n. 6, p. 5498-5505, 2016.
Fluid biophysics
- H Badeeer, Hemodynamics For Medical Students, Advances In Physiology Education, 2001.
- Joachim D Pleil et al. The physics of human breathing: flow, timing, volume, and pressure parameters for normal, on-demand, and ventilator respiration J. Breath Res. 15 042002, 2021.
Data science
- Oliveira, A.L. (2019), Biotechnology, Big Data and Artificial Intelligence. Biotechnol. J., 14: 1800613. https://doi.org/10.1002/biot.201800613.
- Moore JH. Empowering the data science scientist. BioData Min. 2021 Jan 23;14(1):8. doi: 10.1186/s13040-021-00246-x. PMID: 33485343; PMCID: PMC7827983.
- Persidis, A. Data mining in biotechnology. Nat Biotechnol 18, 237–238 (2000). https://doi.org/10.1038/72722.
- Harline K, Martínez-Gómez J, Specht CD and Roeder AHK (2021) A Life Cycle for Modeling Biology at Different Scales. Front. Plant Sci. 12:710590. doi: 10.3389/fpls.2021.710590.
Bioprocess engineering
- Cornell, J.A. Experiments with Mixtures: Designs, Models, and the Analysis of Mixture Data. 3rd. ed. New York, NY: John Wiley & Sons, Inc., 2002.
- COUPER, J.R. Process Engineering Economics. 1st ed. New York: CRC Press, 2003.
- Montgomery, D.C. Design and Analysis of Experiments. 10th. ed. Hoboken, NJ, USA: Wiley, 2020.
- Shuler, M.L.; Kargi, F.; Delisa, M. Bioprocess Engineering: Basic Concepts. Third ed. Upper Saddle River: Prentice Hall, 2017.
TURMAS
Material da Disciplina
Cronograma de Atividades 2023-2
Apresentação disciplina - 29/08/2023
University of São Paulo (USP) - English institutional video
School of Arts, Sciences and Humanities - University of São Paulo - English Version
Shorts Vídeos:
1- Porque é a biodiversidade tão importante? (4.18”)
2- Brazil Unique Biodiversity (1.0”)
3- 10 UNIQUE Animals Found in Brazil (8.53”)
4- Marco Legal da Biodiversidade – Brasil (6.19”)
5- Brazilian biomes (0.30”)
6- How Brazilian citrus production happens in partnership with nature and respecting biodiversity (2.24”)
7- How São Paulo state protects the Atlantic Forest (0.50”)
8- UFSCar PrInt Capes Biodiversity, Ecosystems Functions and Sustainability (3.59”)
9- Brazilian Biodiversity Molecular Power House Project (3.34”)