DA SILVA, GABRIEL ; MILAN, THAÍS MORÉ ; Leopoldino, Andréia Machado . The accumulation of sphingosine kinase 2 disrupts the DNA damage response and promotes resistance to genotoxic agents. GENE, v. 897, p. 148063, 2024.
FUGIO, LAIS BRIGLIADORI ; SILVA, GABRIEL ; FERRAZ, CAMILA LOPES ; TREVISAN, GLAUCE LUNARDELLI ; COELI-LACCHINI, FERNANDA BORCHERS ; GARCIA, CRISTIANA BERNADELLI ; SOUSA, LUCAS OLIVEIRA ; MALTA, TATHIANE MAISTRO ; GIL, CRISTIANE DAMAS ; Leopoldino, Andréia Machado . Accumulation of sphingosine kinase 2 protein induces malignant transformation in oral keratinocytes associated with stemness, autophagy, senescence, and proliferation. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, v. 1871, p. 119616, 2024.
TORRES, LIZETH ANDREA TORRES ; SILVA, GABRIEL ; ALVES, JOVELINA SAMARA FERREIRA ; USHIDA, TATIANE RESENDE ; POTENZA, JULIA ; GARCIA, CRISTIANA BERNADELLI ; SOUSA, LUCAS OLIVEIRA ; LOPES, NORBERTO PEPORINE ; ALMEIDA, LUCIANA OLIVEIRA ; Leopoldino, Andréia Machado . FTY720 increases paclitaxel efficacy in cisplatin-resistant oral squamous cell carcinoma. JOURNAL OF ORAL PATHOLOGY & MEDICINE, v.53(1), p. 42-52, 2024.
COELI-LACCHINI, FERNANDA BORCHERS ; DA SILVA, GABRIEL ; BELENTANI, MONICA ; FERREIRA ALVES, JOVELINA SAMARA ; USHIDA, TATIANE RESENDE ; LUNARDELLI, GLAUCE TREVISAN ; GARCIA, CRISTIANA BERNADELLI ; SILVA, TARCÍLIA APARECIDA ; LOPES, NORBERTO PEPORINE ; Leopoldino, Andréia Machado . Spermidine Suppresses Oral Carcinogenesis through Autophagy Induction, DNA Damage Repair, and Oxidative Stress Reduction. AMERICAN JOURNAL OF PATHOLOGY, v.193(12), p.2172-2181, 2023.
SILVA, GABRIEL DA ; MILAN, THAÍS MORÉ ; CHAGAS, PABLO SHIMAOKA ; TREVISAN, GLAUCE LUNARDELLI ; FERRAZ, CAMILA LOPES ; Leopoldino, Andréia Machado . SET protein as an epigenetics target. Epigenomics, v. 16(4), p. 249-257, 2023.
TAVARES, MARCELA OLIVEIRA ; MILAN, THAÍS MORÉ ; BIGHETTI’TREVISAN, RAYANA LONGO ; Leopoldino, Andréia Machado ; DE ALMEIDA, LUCIANA OLIVEIRA . Pharmacological inhibition of HDAC6 overcomes cisplatin chemoresistance by targeting cancer stem cells in oral squamous cell carcinoma. JOURNAL OF ORAL PATHOLOGY & MEDICINE, v. x, p. x, 2022.
SILVA, G. ; KOWALSKI, L. P. ; MATOS, L. L. ; KULCSAR, M. ; Leopoldino, Andréia M. Profile of sphingolipid-related genes and its association with prognosis highlights sphingolipid metabolism in oral cancer. CANCER BIOMARKERS, v. 32, p. 49-63, 2021.
PADOVANI, KARINA STRINGHETTA ; GOTO, RENATA NISHIDA ; FUGIO, LAIS BRIGLIADORI ; GARCIA, CRISTIANA BERNADELLI ; ALVES, VANI MARIA ; BRASSESCO, MARIA SOL ; GREENE, LEWIS JOEL ; REGO, EDUARDO MAGALHÃES ; Leopoldino, Andréia Machado . Crosstalk between hnRNP K and SET in ATRA induced differentiation in acute promyelocytic leukemia. FEBS Open Bio, v. x, p. x, 2021.
ROMAN, R. F. ; SILVA, G. ; SILVA, R. M. ; USHIDA, T. R. ; SILVA, R. R. ; LACCHINI, R. ; MATOS, L. L. ; KOWALSKI, L. P. ; LOPES, N. P. ; Andréia M. Leopoldino . Sphingolipids signature in plasma and tissue as diagnostic and prognostic tools in oral squamous cell carcinoma. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, v. 1867, p. 159057, 2021.
FUGIO, LAIS BRIGLIADORI ; COELI-LACCHINI, FERNANDA B. ; Leopoldino, Andréia Machado. Sphingolipids and Mitochondrial Dynamic. Cells, v. 9, p. 581, 2020.
SOUSA, LUCAS OLIVEIRA ; SOBRAL, LAYS MARTIN; DE ALMEIDA, LUCIANA OLIVEIRA; GARCIA, CRISTIANA BERNADELLI; GREENE, LEWIS JOEL; Leopoldino, Andréia Machado. SET protein modulates H4 histone methylation status and regulates miR-137 level in oral squamous cell carcinoma. Epigenomics, v. x, p. epi-2019-0181, 2020.
GOTO, RENATA NISHIDA ; SOBRAL, LAYS MARTIN; STRINGHETTA-PADOVANI, KARINA; GARCIA, CRISTIANA B. ; DA SILVA, GABRIEL ; VITEK, MICHAEL P. ; LEOPOLDINO, ANDREIA MACHADO . Synergic effect of OP449 and FTY720 on oral squamous cell carcinoma. EUROPEAN JOURNAL OF PHARMACOLOGY, v. 882, p. 173268, 2020.
OUCHIDA, A. T. ; TUDELLA, V. G. ; QUEIROZ, A. L. ; BRAUER, V. ; CAVALCANTI NETO, M. P. ; Sousa, L.O. ; Uyemura, S.A. ; CURTI, C. ; Andréia M Leopoldino . SET protein accumulation prevents cell death in head and neck squamous cell carcinoma through regulation of redox state and autophagy. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, v. 1866, p. 623-637, 2019.
LIMA, SANTIAGO ; TAKABE, KAZUAKI ; NEWTON, JASON ; SAURABH, KUMAR ; YOUNG, MEGAN M. ; LEOPOLDINO, ANDREIA MACHADO ; HAIT, NITAI C. ; ROBERTS, JANE L. ; WANG, HONG-GANG ; DENT, PAUL ; MILSTIEN, SHELDON ; BOOTH, LAURENCE ; SPIEGEL, SARAH . TP53 is required for BECN1- and ATG5-dependent cell death induced by sphingosine kinase 1 inhibition. Autophagy, v. 11, p. 1-16, 2018.
GOTO, RENATA NISHIDA ; SOBRAL, LAYS MARTIN ; SOUSA, LUCAS OLIVEIRA ; GARCIA, CRISTIANA BERNADELLI ; LOPES, NORBERTO PEPORINE ; MARÍN-PRIDA, JAVIER ; OCHOA-RODRÍGUEZ, ESTAEL ; VERDECIA-REYES, YAMILA ; PARDO-ANDREU, GILBERTO LÁZARO ; Curti, Carlos ; Leopoldino, Andréia Machado . Anti-cancer activity of a new dihydropyridine derivative, VdiE-2N, in head and neck squamous cell carcinoma. EUROPEAN JOURNAL OF PHARMACOLOGY, v. 819, p. 198-206, 2018.
Almeida, Luciana O. ; NETO, MARINALDO P. C. ; SOUSA, LUCAS O. ; TANNOUS, MARYNA A. ; Curti, Carlos ; Leopoldino, Andreia M. . SET oncoprotein accumulation regulates transcription through DNA demethylation and histone hypoacetylation. OncoTarget, 8:26802-26818, 2017.
Sobral, Lays M. ; COLETTA, R. D. ; ALBERICI, L. C. ; CURTI, C. ; Leopoldino, Andreia M. . SET/I2PP2A overexpression induces phenotypic, molecular, and metabolic alterations in an oral keratinocyte cell line. FEBS Journal, p. x, 2017.
CAMPOS, L. ; RODRIGUEZ, Y. ; MACHADO LEOPOLDINO, A. ; HAIT, N. C. ; LOPEZ BERGAMI, P. ; CASTRO, M. ; SANCHEZ, E. ; MACEYKA, M. ; SPIEGEL, S. ; ALVAREZ, S. E. . Filamin A Expression Negatively Regulates Sphingosine-1-Phosphate-Induced NF- B Activation in Melanoma Cells by Inhibition of Akt Signaling. Molecular and Cellular Biology (Print), v. 36, p. 320-329, 2016.
SAYURI, C. M. ; ALMEIDA, L. O. ; GUIMARAES, D. M. ; MARTINS, M. D. ; PAPAGERAKIS, P. ; PAPAGERAKIS, S. ; LEOPOLDINO, A. M. ; CASTILHO, R. M. ; SQUARIZE, C. . PI3K-PTEN dysregulation leads to mTOR-driven upregulation of the core clock gene BMAL1 in normal and malignant epithelial cells. OncoTarget, p. xx, 2016.
SOUSA, LUCAS O ; SOBRAL, LAYS M ; MATSUMOTO, CAMILA S ; SAGGIORO, FABIANO P ; LÓPEZ, ROSSANA V M ; PANEPUCCI, RODRIGO A ; Curti, Carlos ; SILVA, WILSON A ; GREENE, LEWIS J ; LEOPOLDINO, ANDRÉIA M . Lymph node or perineural invasion is associated with low miR-15a, miR-34c and miR-199b levels in head and neck squamous cell carcinoma. BBA Clinical, v. x, p. xx-164, 2016.
Almeida, Luciana O. ; GOTO, RENATA N. ; NETO, MARINALDO P.C. ; SOUSA, LUCAS O. ; Curti, Carlos ; Leopoldino, Andréia M. SET overexpression in HEK293 cells regulates mitochondrial uncoupling proteins levels within a mitochondrial fission/reduced autophagic flux scenario. Biochemical and Biophysical Research Communications (Print), v. xx, p. xx, 2015
ALMEIDA, L. O. ; Garcia, C.B. ; SILVA, F. A. M.. ; CURTI, C. ; Leopoldino, Andréia M. . Accumulated SET protein up-regulates and interacts with hnRNPK, increasing its binding to nucleic acids, the Bcl-xS repression, and cellular proliferation. Biochemical and Biophysical Research Communications (Print), p. xx, 2014.
SOBRAL, L. M. ; Sousa, L.O. ; COLETTA, R. D. ; GREENE, L. J. ; Tajara, E. H. S. ; GUTKIND, S. ; CURTI, C. ; Leopoldino, Andréia Machado . Stable SET knockdown in head and neck squamous cell carcinoma promotes cell invasion and the mesenchymal-like phenotype in vitro, as well as necrosis, cisplatin sensitivity and lymph node metastasis in xenograft tumor models. Molecular Cancer, v. 13, p. 32, 2014.
LEOPOLDINO, AM; Squarize, Cristiane H. ; Garcia, C.B. ; ALMEIDA, L. O. ; PESTANA, C. R. ; Uyemura, S.A. ; Tajara, EH ; GUTKIND, S. ; CURTI, C. . Accumulation of the SET protein in HEK293T cells and mild oxidative stress: cell survival or death signaling. Molecular and Cellular Biochemistry, v. 363, p. 65-74, 2012.
ALMEIDA, L. O. ; GOTO, R. N. ; PESTANA, C. R. ; Uyemura, S.A. ; GUTKIND, S. ; CURTI, C. ; Leopoldino AM . SET overexpression decreases cell detoxification efficiency: ALDH2 and GSTP1 are downregulated, DDR is impaired and DNA damage accumulates. The FEBS Journal (Print), v. 279, p. 4615-4628, 2012.
Leopoldino, Andréia M.; Squarize, Cristiane H. ; Garcia, Cristiana B. ; Almeida, Luciana O. ; Pestana, Cezar R. ; Sobral, Lays M. ; Uyemura, Sérgio A. ; Tajara, Eloiza H. ; Silvio Gutkind, J. ; Curti, Carlos . SET protein accumulates in HNSCC and contributes to cell survival: Antioxidant defense, Akt phosphorylation and AVOs acidification. Oral Oncology (1997), v. vol.x, p. xx-xx, 2012.
CARREGARO, F. ; CARTA, A. ; LOBO, S. A. ; Tajara, EH ; LEOPOLDINO, AM . Polymorphisms IL10-819 and TLR-2 are potentially associated with sepsis in Brazilian patients. Memórias do Instituto Oswaldo Cruz (Impresso), v. 105, p. 649-656, 2010.
LEOPOLDINO, AM; CARREGARO, F. ; Tomich CHPS ; Feitosa AO ; MANCINI, U. M. ; FREITAS, J. M. ; Tajara, E. H. S. . Sequence and transcriptional study of HNRPK pseudogenes, and expression and molecular modeling analysis of hnRNP K isoforms. Genome (Ottawa. Online), v. 50, p. 451-462, 2007.
LEOPOLDINO, AM; CANDURI, F ; CABRAL, H ; JUNQUEIRA, M ; DEMARQUI, A ; APPONI, L ; FONSECA, I ; DOMONT, G ; SANTOS, D ; VALENTINI, S . Expression, purification, and circular dichroism analysis of human CDK9. Protein Expression and Purification, Netherlands, v. 47, p. 614-620, 2006.
Bavoux C ; LEOPOLDINO, AM ; Ogi T ; Bieth A ; Kumari A ; Lehmann A ; PENA, S. D. J. ; Renato Machado C ; Hoffmann JS ; Cazaux C . Misregulation of the error-prone DNA polymerase kappa promotes pleiotropic genetic disorders and tumorigenesis. Cancer Research, v. 65, n.1, p. 325-330, 2005.
Anacleto, Charles ; Leopoldino, Andréia M. ; Rossi, Benedito ; Soares, Fernando A. ; Lopes, Ademar ; Rocha, José Cláudio C. ; Caballero, Otávia ; Camargo, Anamaria A. ; Simpson, Andrew J. G. ; Pena, Sérgio D. J. Colorectal Cancer “Methylator Phenotype”: Fact or Artifact?. Neoplasia (New York), v. 7, n.4, p. 331-335, 2005.
LEOPOLDINO, AM; PENA, S. D. J. . The mutational spectrum of human autosomal tetranucleotide microsatellites. Human Mutation, EUA, v. 21, n.1, p. 71-79, 2003.
LEOPOLDINO, AM; CARVALHOI, M. R. S. ; AGUIAR, M. J. B. ; PENA, S. D. J. . Prevalence of Prader-Willi and Angelman syndromes among mentally retarded boys in Brazil. Journal of Medical Genetics, EUA, v. 36, p. 498-498, 1999.
link para Curriculo lattes CNPq, ORCID.