The Pharmaceutical Technology Laboratory – FCFRP-USP

The Bentley’s group is engaged in the research field of nanotechnology applied mainly for skin diseases. The research is based in the development of nano delivery systems which presents  compatible characteristics with skin tissue. The appropriate interaction between the nanosystem with the tissue can improve the skin penetration of drugs and retention in its layers. The main studied skin diseases are psoriasis, skin cancer, vitiligo and skin inflammations. New researches are being explored with targeted enzymatic nano delivery systems against lysosomal storage disease (Pompe).

The Pharmaceutical Technology Laboratory, supervised by Profa. Dr. Maria Vitória Lopes Badra Bentley and belonging to the Faculty of Pharmaceutical Sciences of Ribeirão Preto (FCFRP-USP), University of São Paulo (USP), is introduced by graduate students Angelo Caron and Ana Vitória Pupo, who tell us about some of the activities carried out by the group and on the research project they participate in.. Published by  Ilha do Conhecimento

The Pharmaceutical Technology Laboratory, FCFRP-USP, is presented by postgraduate students Angelo Caron and Ana Vitória Pupo.

Research and Development in Release Systems for Gene Therapy 

 It constitutes the most recent line of research of the group and started with the main researcher of a Thematic Project, which brought together integrated strategies for the Treatment of Tuberculosis, with the main focus on Vaccination and Gene Therapy. The development of this line is consolidating the group in the area of ​​release systems based on liquid crystals, adding knowledge and working techniques. This line opened a new research area, which is the development of delivery systems and carrier molecules for peptide drugs, aligning the group’s research with future trends for the therapies of the most varied pathologies, which at the moment, have numerous limitations of delivery and administration.

The delivery systems developed in this line are also being studied for topical application of peptide drugs for the treatment of cutaneous pathologies and topical administration of active ingredients in cosmetics. More recently, the group has been pioneering research on topical and systemic release systems for carrying and releasing siRNA in silencing gene therapy aimed at treating skin diseases such as psoriasis, vitiligo and skin cancer.

Faculty of Pharmaceutical Sciences of Ribeirão Preto (FCFRP-USP), University of São Paulo (USP).