The Immunology Graduate Program was created in 1983 based on the joint action of professors from the newly created Department of Immunology at the Institute of Biomedical Sciences of the University of Sao Paulo (ICB/USP). The Master’s and PhD programs were created simultaneously and received an A rating in the very first Coordination for the Improvement of Higher Education Personnel (CAPES) evaluation. Since the 1998-2000 period, when CAPES changed its criteria and ratings, our program received a rating of 6, but in the following evaluations it received the maximum rating (7), which it has maintained since then. A hallmark feature of our program is the variety of research areas of its advisors. We offer research in inflammation, allergy, cancer, vector immunobiology, immunogenetics, neuroimmunomodulation, immunology of bacteria, viruses, fungi and protozoa, complement system, primary and secondary immunodeficiencies, autoimmunity, immunometabolism, cell death, immunoparasitology, toxins and poisons and neonatal and mucosal immunity, among others.