José Alexandre Marzagão Barbuto

Título: Professor Associado
Laboratory: Imunologia de Tumores
Phone: 55 (11) 3091-7375
E-mail: jbarbuto@icb.usp.br
Lattes: http://lattes.cnpq.br/0400432783033740

Research line

Immunobiology of tumors and dendritic cells

Summary

The research in our laboratory I dedicated to the study of the relationships between the immune system and neoplasia, both in human patients and in animal models. We have been studying functional alterations in different immune cell populations, including T and B lymphocytes, macrophages and dendritic cells in patients with different types of cancer. At the same time we have attempting to develop dendritic cell-based immunotherapeutic approaches for cancer and to identify predictive factors of response in this setting.

Some publications from the laboratory

1. Clavijo-Salomon MA et al. Human NK cells prime inflammatory DC precursors to induce Tc17 differentiation. Blood Adv. 2020 Aug 25;4(16):3990-4006. doi: 10.1182/bloodadvances.2020002084.
2. de Azevedo-Santos APS et al. Could Increased Expression of Hsp27, an “Anti-Inflammatory” Chaperone, Contribute to the Monocyte-Derived Dendritic Cell Bias towards Tolerance Induction in Breast Cancer Patients? Mediators Inflamm. 2019 Nov 18;2019:8346930. doi: 10.1155/2019/8346930.
3. Pinho MP et al. Frequency determination of breast tumor-reactive CD4 and CD8 T cells in humans: unveiling the antitumor immune response. Oncoimmunology. 2019 May 15;8(8):1607674. doi: 10.1080/2162402X.2019.1607674.
4. Patente TA et al. Human Dendritic Cells: Their Heterogeneity and Clinical Application Potential in Cancer Immunotherapy. Front Immunol. 2019 Jan 21;9:3176. doi: 10.3389/fimmu.2018.03176.
5. Vitor MT, et al. Cationic liposomes produced via ethanol injection method for dendritic cell therapy. J Liposome Res. 2017 Dec;27(4):249-263. doi: 10.1080/08982104.2016.1196702. Epub 2016 Jul 7.
6. Porchia BFMM et al. Herpes Simplex Virus Glycoprotein D Targets a Specific Dendritic Cell Subset and Improves the Performance of Vaccines to Human Papillomavirus-Associated Tumors. Mol Cancer Ther. 2017 Sep;16(9):1922-1933. doi: 10.1158/1535-7163.MCT-17-0071. Epub 2017 May 18.
7. Toniolo PA et al. Deregulation of SOCS5 suppresses dendritic cell function in chronic lymphocytic leukemia. Oncotarget. 2016 Jul 19;7(29):46301-46314. doi: 10.18632/oncotarget.10093.
8. Rodrigues CP et al. Tolerogenic IDO(+) Dendritic Cells Are Induced by PD-1-Expressing Mast Cells. Front Immunol. 2016 Jan 25;7:9. doi: 10.3389/fimmu.2016.00009.
9. Romagnoli GG et al. Dendritic Cell-Derived Exosomes may be a Tool for Cancer Immunotherapy by Converting Tumor Cells into Immunogenic Targets. Front Immunol. 2015 Jan 19;5:692. doi: 10.3389/fimmu.2014.00692.
10. Ramos RN et al. Monocyte-derived dendritic cells from breast cancer patients are biased to induce CD4+CD25+Foxp3+ regulatory T cells. J Leukoc Biol. 2012 Sep;92(3):673-82. doi: 10.1189/jlb.0112048. Epub 2012 May 25.
11. Baleeiro RB et al. High frequency of immature dendritic cells and altered in situ production of interleukin-4 and tumor necrosis factor-alpha in lung cancer. Cancer Immunol Immunother. 2008 Sep;57(9):1335-45. doi: 10.1007/s00262-008-0468-7. Epub 2008 Feb 20.
12. Barbuto JA et al. Dendritic cell-tumor cell hybrid vaccination for metastatic cancer. Cancer Immunol Immunother. 2004 Dec;53(12):1111-8. doi: 10.1007/s00262-004-0551-7.

Team