Vera Lúcia Garcia Calich, PhD

Título: Professora Titular
Laboratory of Immunology of fungal infections
Telephone: 55 (11) 3091 7397
E-mail: vlcalich@icb.usp.br
Lattes: http://lattes.cnpq.br/2262742706305608

 

 

 

Abstract

The studies aim to characterize all aspects of host responses associated with immunoprotection or exacerbation of pulmonary paracoccidioidomycosis, an endemic mycosis in Latin America, and the most prevalent systemic mycosis in Brazil. Mechanisms of innate and adaptive immunity are comparatively studied using genetically resistant and susceptible inbred mice to Paracoccidioides brasiliensis, the causative agent of this mycosis. With particular emphasis the group has characterized the influence of dendritic cells and pattern recognition receptors (PRRs) such as Toll-like Receptors, Dectin-1, Mannose Receptors, and NOD-like Receptors in the activation of innate immunity, and how this initial response of hosts influences the adaptive immunity that subsequently develops.

 

Research interests

Immunology of fungal infections

 

Published Papers (2017-2021)

1-NOGUEIRA-NETO, JOES ; LOURES, FLAVIO V. ; SCHANOSKI, ALESSANDRA S. ; ANDRADE, DAVID A. G. GONZATTI, MICHELANGELO B. ; Costa, Tania A. ; VIVANCO, BRUNO C. ; XANDER, PATRÍCIA ; ROSA, DANIELA S.;  CALICH, VERA L. G. ; KELLER, ALEXANDRE C. . Invariant Natural Killer T Cells as Key Players in Host Resistance against Paracoccidioides brasiliensis. J. IMMUNOL. RES., v. 2021, p. 1-11, 2021.

 

2. DE ARAÚJO, ELISEU F. ; Loures, Flávio V. ; PREITE, NYCOLAS W. ; FERIOTTI, CLÁUDIA ; GALDINO, NAYANE AL ; COSTA, TÂNIA A. ; CALICH, VERA L. G. . AhR Ligands Modulate the Differentiation of Innate Lymphoid Cells and T Helper Cell Subsets That Control the Severity of a Pulmonary Fungal Infection. FRONTIERS IN IMMUNOLOGY , v. 12, p. 630938., 2021.

 

3. MANGANELI POLONIO, CAROLINA ; LONGO DE FREITAS, CARLA ; GARCIA DE OLIVEIRA, MARÍLIA ; ROSSATO, CRISTIANO ; NOGUEIRA BRANDÃO, WESLEY ; GHABDAN ZANLUQUI, NÁGELA; GOMES DE OLIVEIRA,LILIAN ; AYUMI NISHIYAMA MIMURA, LUIZA ; BRAGA BARROS SILVA, MAYSA ; CALICH, VERA, L G  ; GIL NISENBAUM, MARCELO ; HALPERN, SILVIO ; EVANGELISTA, LUCILA ; MALUF, MARIANGELA ; PERIN, PAULO; EDUARDO CZERESNIA, CARLOS ; SCHATZMANN PERON, JEAN PIERRE . Murine endometrial-derived mesenchymal stem cells suppress experimental autoimmune encephalomyelitis depending on indoleamine-2,3-dioxygenase expression. CLINICAL SCIENCE , v. 135, p. 1065-1082, 2021.

 

4-FREIRE, PAULA P. ; MARQUES, ALEXANDRE H.C. ; BAIOCCHI, GABRIELA C. ; SCHIMKE, LENA F. ; FONSECA, DENNYSON L.M. ; SALGADO, RANIERI C.; FILGUEIRAS, IGOR S. ; NAPOLEAO, SARAH M.S. ; PLAÇA, DESIRÉE R.; AKASHI, KAREN T. ; HIRATA, THIAGO DOMINGUEZ CRESPO ; EL KHAWANKY, NADIA ; GIIL, LASSE M. ; CABRALMIRANDA, GUSTAVO ; CARVALHO, ROBSON F. ; FERREIRA, LUIS CARLOS S. ; CONDINO-NETO, ANTONIO ; NAKAYA, HELDER I. ; JURISICA, IGOR ; OCHS, HANS D. ; CAMARA, NIELS OLSEN SARAIVA ; CALICH, VERA LÚCIA G. ; CABRAL-MARQUES, OTAVIO . The relationship between cytokine and neutrophil gene network distinguishes SARS-CoV-2-infected patients by sex and age. JCI INSIGHT, v. 6, p. e147535., 2021.

 

5-DE ARAÚJO, ELISEU FRANK ; PREITE, NYCOLAS WILLIAN ; VELDHOEN, MARC ; LOURES, FLÁVIO VIEIRA; CALICH, VERA LÚCIA GARCIA . Pulmonary paracoccidioidomycosis in AhR deficient hosts is severe and associated with defective Treg and Th22 responses. SCIENTIFIC REPORTS , v. 10, p. 11312, 2020.

 

6- PREITE, NYCOLAS WILLIAN ; FERIOTTI, CLAUDIA ; SOUZA DE LIMA, DHÊMERSON ; DA SILVA, BRUNO, BORGES ; CONDINO-NETO, ANTÔNIO ; PONTILLO, ALESSANDRA ; CALICH, VERA LÚCIA GARCIA ; LOURES, FLÁVIO VIEIRA . The Syk-Coupled C-Type Lectin Receptors Dectin-2 and Dectin-3 Are Involved in Paracoccidioides brasiliensis Recognition by Human Plasmacytoid Dendritic Cells. FRONTIERS IN IMMUNOLOGY , v. 9, p. 464, 2018.

 

7. CABRAL-MARQUES, OTAVIO TAKAHASHI FRANÇA, TABATA AL-SBIEI, ASHRAF FRIEDERIKE SCHIMKE, LENA; KHAN, TAJ ALI FERIOTTI, CLAUDIA DA COSTA, TANIA ALVES JUNIOR, OSVALDO REIS WEBER, CRISTINA WORM FERREIRA, JANAÍRA FERNANDES TAVARES, FABIOLA SCANCETTIVALENTE, CLAUDIA DI GESU, REGINA SUMIKO WATANABE IQBAL, ASIF RIEMEKASTEN, GABRIELA AMARANTE-MENDES, GUSTAVO PESSINI MARZAGÃO BARBUTO, JOSÉ ALEXANDRE, COSTA-CARVALHO, BEATRIZ TAVARES PEREIRA, PAULO VITOR SOEIRO, FERNANDEZ-CABEZUDO, MARIA J. CALICH, VERA LUCIA GARCIA NOTARANGELO, LUIGI D. TORGERSON, TROY R. AL-RAMADI, BASEL K. OCHS, HANS D. , et al. ; CD40 ligand deficiency causes functional defects of peripheral neutrophils that are improved by exogenous IFN-γ. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY , v. 141, p. 1-65, 2018.

 

8- CALICH, VERA L. G.; MAMONI, RONEI L. ; LOURES, FLÁVIO V.  Regulatory T cells in paracoccidioidomycosis. VIRULENCE , v. 9, p. 1-12, 2018.

 

9. GALDINO, NAYANE A. L. ; LOURES, FLÁVIO V. ; DE ARAÚJO, ELISEU F. ; DA COSTA, TANIA A. ; PREITE,  NYCOLAS W. ; CALICH, VERA LÚCIA G. . Depletion of regulatory T cells in ongoing paracoccidioidomycosis rescues protective Th1/Th17 immunity and prevents fatal disease outcome. SCIENTIFIC REPORTS , v. 8, p. 16544, 2018.

 

10. MIROTTI, LUCIANA CRISTINA ; ALBERCA CUSTÓDIO, RICARDO WESLEY ; GOMES, ELIANE ; RAMMAURO, FLORENCIA ; DE ARAUJO, ELISEU FRANK ; CALICH, VERA LUCIA GARCIA ; RUSSO, MOMTCHILO . CpG-ODN Shapes Alum Adjuvant Activity Signaling via MyD88 and IL-10. FRONTIERS IN IMMUNOLOGY , v. 8, p. 47, 2017.

 

11-FERIOTTI, CLAUDIA ; DE ARAÚJO, ELISEU FRANK ; LOURES, FLAVIO VIEIRA ; DA COSTA, TANIA ALVES ; GALDINO, NAYANE ALVES DE LIMA ; ZAMBONI, DARIO SIMÕES ; CALICH, VERA LUCIA GARCIA . NOD-Like Receptor P3 Inflammasome Controls Protective Th1/Th17 Immunity against Pulmonary Paracoccidioidomycosis. FRONTIERS IN IMMUNOLOGY , v. 8, p. 1/786-15, 2017.

 

12. DE ARAÚJO, ELISEU FRANK ; FERIOTTI, CLAUDIA ; GALDINO, NAYANE ALVES DE LIMA ; PREITE, NYCOLAS WILLIAN ; LOURES, FLÁVIO VIEIRA; CALICH, VERA LÚCIA GARCIA . The IDO-AhR Axis Controls Th17/Treg Immunity ina Pulmonary Model of Fungal Infection. FRONTIERS IN IMMUNOLOGY , v. 8, p. 880-15, 2017.

 

13. LIMA-JUNIOR, DJALMA S. ; MINEO, TIAGO W. P. ; CALICH, VERA L. G. ; ZAMBONI, DARIO S. . Dectin-1 Activation during Leishmania amazonensis Phagocytosis Prompts Syk-Dependent Reactive Oxygen Species Production To Trigger Inflammasome Assembly and Restriction of Parasite Replication. JOURNAL OF IMMUNOLOGY , v. 199, p. ji1700258, 2017.

 

14. DE ARAÚJO, ELISEU FRANK ; LOURES, FLÁVIO VIEIRA ; FERIOTTI, CLÁUDIA ; COSTA, TANIA ; VACCA, CARMINE ; PUCCETTI, PAOLO ; ROMANI, LUIGINA ; CALICH, VERA LÚCIA GARCIA . Disease Tolerance Mediated by Phosphorylated Indoleamine-2,3 Dioxygenase Confers Resistance to a Primary Fungal Pathogen. FRONTIERS IN IMMUNOLOGY, v. 8, p. 1522, 2017.

 

15. SCHIMKE, LENA F ; HIBBARD, JAMES ; MARTINEZ-BARRICARTE, RUBEN ; KHAN, TAJ ALI ; DE SOUZA CAVALCANTE, RICARDO ; BORGES DE OLIVEIRA JUNIOR, EDGAR ; TAKAHASHI FRANÇA, TABATA ; IQBAL, ASIF ; YAMAMOTO, GUILHERME ; ARSLANIAN, CHRISTINA ; FERIOTTI, CLAUDIA ; DA COSTA, TANIA ALVES ; BUSTAMANTE, JACINTA ; BOISSON-DUPUIS, STÉPHANIE ; CASANOVA, JEAN-LAURENT ; MARZAGAO BARBUTO, JOSÉ ALEXANDRE ; ZATZ, MAYANA ; PONCIO MENDES, RINALDO ; GARCIA CALICH, VERA LUCIA ; OCHS, HANS D ; TORGERSON, TROY R ; CABRAL-MARQUES, OTÁVIO ; CONDINO-NETO, ANTONIO . Paracoccidioidomycosis associated with a heterozygous STAT4 mutation and impaired IFN-γ immunity. JOURNAL OF INFECTIOUS DISEASES , v. 57, p. 1-12, 2017.

 

16. ERSCHING, JONATAN ; BASSO, ALEXANDRE SALGADO ; CALICH, VERA LUCIA GARCIA; BORTOLUCI, KARINA RAMALHO ; RODRIGUES, MAURÍCIO M.  A Human Trypanosome Suppresses CD8+ T Cell Priming by Dendritic Cells through the Induction of Immune Regulatory CD4+ Foxp3+ T Cells. PLOS PATHOGENS, v. 12, p. e1005698.