Avenida Professor Lineu Prestes 1524, Butantã, São Paulo – SP, ZIP 05508-000
ICB-USP, Biomédicas I, Room 302
Tel.: +55 (11) 3091-0923
The Laboratory of the Studies of the Molecular Mechanisms of β cell death aims to elucidate the molecular mechanisms involved in pancreatic β cell demise that leads to the development of Diabetes mellitus. These cells are responsible for production and secretion of insulin, a hypoglycemic hormone – thus its dysfunction and death leads to the chronic hyperglycemia observed in Diabetes mellitus.
Currently, we investigate the molecular mechanisms that lead to β cell dysfunction and death in models of Type 1 Diabetes mellitus (T1DM), with an emphasis on the role of the transcription factor HNF4-α and the enzymes of the NADPH oxidase family. In addition, we evaluate the mechanisms involved in the beneficial effects of physical exercise in protecting β cells in T1DM models.
A better understanding of these pathways may allow the use of this knowledge in the development of therapeutic strategies preventing β cell destruction during insulitis and after Langerhans islet transplant in clinic models of the disease and in patients.
Immunofluorescence for identification of insulin-positive cells (pancreatic β cells) in mouse islets of a control (left) or diabetic (right) animal. Insulin is shown in green (Alexa Fluor 488) and nuclei in blue (DAPI). Magnification 40x from original. Note decreased insulin-positive cells in islets of diabetic animals.