Publicações e congressos – Laboratório do Estudo dos Mecanismos de Morte da Células beta

Publication

Here you can find the most recent results from our group. Click on the link to be redirected to the scientific articles or resume presented in congress.

Early Cytokine-Induced Transient NOX2 Activity Is ER Stress-Dependant and Impacts ß-Cell Function and Survival

Vilas-Boas, Eloisa Aparecida; Carlein, Christopher; Nalbach, Lisa; Almeida, Davidson Correa; Ampofo, Emmanuel; Carpinelli, Angelo Rafael; Roma, Leticia Prates; Ortis, Fernanda

Transient NADPH oxidase 2-dependent H2O2 production drives early palmitate-induced lipotoxicity in pancreatic islets

Vilas-Boas, Eloisa Aparecida; Nalbach, Lisa; Ampofo, Emmanuel; Lucena, Camila Ferraz; Naudet, Léa; Ortis, Fernanda; Carpinelli, Angelo Rafael; Morgan, Bruce; Roma, Leticia Prates

Beneficial effects of physical exercise for β-cell maintenance in a type 1 diabetes mellitus animal model

Villaça, Catharina De Barros Pimentel; Paula, Carolina Cavalcante; Oliveira, Caroline Cruz; Vilas-Boas, Eloisa Aparecida; Santos’silva, Junia Carolina; Oliveira, Sérgio Ferreira; Abdulkader, Fernando; Ferreira, Sandra Mara; Ortis, Fernanda

Caracterização do modelo animal de camundongos knockout condicional para hnf4alfa em células beta

Villaça, Catharina de Barros Pimentel; Santos, Gustavo Jorge; Ortis, Fernanda

Congress: FeSBE Regional (Federação de Sociedades de Biologia Experimental)

Bihormonal islet cells: a transdifferentiating effect of physical exercise

Congress: Insulin 100

Pre-treatment with IL-6 is deleterious for cytokine-induced beta cell death

Oliveira, VR; Paula, CC; Ortis, F

Congress: XX SBBC (Sociedade Brasileira de Biologia Celular)

Physical exercise partially maintains beta-cell mass in type 1 diabetes mellitus mice model

Congress: XX SBBC (Sociedade Brasileira de Biologia Celular)

ARHGAP21 Acts as an Inhibitor of the Glucose-Stimulated Insulin Secretion Process

Ferreira, Sandra M. ; Costa-Júnior, José M. ; Kurauti, Mirian A. ; Leite, Nayara C. ; Ortis, Fernanda ; Rezende, Luiz F. ; Barbosa, Helena C. ; Boschero, Antonio C. ; Santos, Gustavo J.

Frontiers in Endocrinology, v. 11, p. 599165, 2020

Papel da NADPH oxidase-2 na disfunção e morte da célula beta pancreática

Vilas-Boas, Eloisa Aparecida; Nalbach, Lisa; Almeida, Davidson Correa; Ampofo, Emmanuel; Carpinelli, Angelo Rafael; Roma, Leticia Prates; Ortis, Fernanda

Congress: I Simpósio do PPG Fisiologia Humana

Hepatocyte Nuclear Factor-4alpha as a Target to Treat DM

dos Santos, GJ; Ruoso, C; Ferreira, SM; Ortis, F; Rafacho, A; Di Stefano, AG; Pechberty, S; Boschero, AC

Congress: ENDO 2019 – 101st Annual Meeting of the Endocrine Society

The non-canonical NF-κB pathway and its contribution to β-cell failure in diabetes

Meyerovich, Kira; Ortis, Fernanda; Cardozo, Alessandra K.

Journal of Molecular Endocrinology, v. 61, p. F1-F6, 2018

Prolactin protects against cytokine-induced beta-cell death by NFκB and JNK inhibition

Nardelli, Tarlliza R ; Vanzela, Emerielle C ; Benedicto, Keli C ; Brozzi, Flora ; Fujita, André ; Cardozo, Alessandra K ; Eizirik, Décio L ; Boschero, A. C. ; Ortis, F.

Journal of Molecular Endocrinology, v. 61, p. 25-36, 2018

O Efeito Protetor do Exercício Físico em Ilhotas Pancreáticas de Animais Expostos a Doses Baixas e Múltiplas de Estreptozotocina

Paula, Carolina Cavalcante; Ferreira, Sandra Mara; Oliveira, Caroline Cruz; Ortis, Fernanda

Congress: CPDM (Congresso Paulista de Diabetes e Metabolismo)

Envolvimento de Nox1 na viabilidade de células secretoras de insulina

Vilas-Boas, Eloisa Aparecida; Ortis, Fernanda; Carpinelli, Angelo Rafael

Congress: CPDM (Congresso Paulista de Diabetes e Metabolismo)

Beneficial Effects of Physical Exercise in Pancreatic Islets of TD1 Animal Models

Paula, Carolina Cavalcante; Ferreira, Sandra Mara; Oliveira, Caroline Cruz; Ortis, Fernanda

Congress: XIX SBBC (Sociedade Brasileira de Biologia Celular)

The Influence of NOX2 in Pancreatic beta cells in a Model of Streptozotocin Induced TD1

Oliveira, Caroline Cruz; Vilas-Boas, Eloisa Aparecida; Ortis, Fernanda

Congress: XIX SBBC (Sociedade Brasileira de Biologia Celular)

Study of the Role of HNF4α in the Dysfunction and Destruction of Pancreatic beta cells During the Development of Type 1 Diabetes Mellitus

Di Stefano, Angelo Gustavo; Ferreira, Sandra Mara; Oliveira, Caroline Cruz; Ortis, Fernanda

Congress: XIX SBBC (Sociedade Brasileira de Biologia Celular)

NADPH Oxidase and beta cell impairement during inflammation

Vilas-Boas, Eloisa Aparecida; Almeida, Davidson Correa; Oliveira, Caroline Cruz; Villaça, Catharina de Barros Pimentel; Ortis, Fernanda; Carpinelli, Angelo Rafael

Hepatocyte Nuclear Factor alfa as a Target to Treat DM

Santos, Gustavo J. ; Ferreira, SM ; Ortis, F. ; Scharfmann, R ; Boschero, AC

Congress: CPDM (Congresso Paulista de Diabetes e Metabolismo)

A insulina modula a expressão de fatores que caracterizam o fenótipo de célula delta em ilhotas pancreáticas de camundongos C57/BL6

Ferreira, SM ; Santos, Gustavo J. ; Ortis, F. ; Santos, C ; Kurauti, MA ; Costa-Júnior, JM ; Vettorazzi, Jean F. ; Boschero, AC

Congress: CPDM (Congresso Paulista de Diabetes e Metabolismo)

The non-canonical NF-κB pathway is induced by cytokines in pancreatic beta cells and contributes to cell death and proinflammatory responses in vitro

Meyerovich, Kira ; Fukaya, Makiko ; Terra, Leticia F. ; Ortis, Fernanda ; Eizirik, Decio L. ; Cardozo, Alessandra K.

Diabetologia (Berlin), v. 59, p. 512-521, 2016

Endoplasmic reticulum stress and the unfolded protein response in pancreatic islet inflammation

Meyerovich, Kira; Ortis, Fernanda; Allagnat, Florent; Cardozo, Alessandra K.

Journal of Molecular Endocrinology, v. 57, p. R1-R17, 2016

A20 inhibits β-cell Apoptosis by Multiple Mechanisms and Predicts Residual β-cell Function in Type 1 Diabetes

Fukaya, Makiko ; Brorsson, Caroline A. ; Meyerovich, Kira ; Catrysse, Leen ; Delaroche, Diane ; Vanzela, Emerielle C. ; Ortis, Fernanda ; Beyaert, Rudi ; Nielsen, Lotte B. ; Andersen, Marie L. ; Mortensen, Henrik B. ; Pociot, Flemming ; Loo, Geert Van ; Størling, Joachim ; Cardozo, Alessandra K.

Molecular Endocrinology (Baltimore, Md.), v. 1, p. me.2015-1176, 2015

JunB protects β-cells from lipotoxicity via the XBP1-AKT pathway

Cunha, D.A. ; Gurzov, E N ; Naamane, N ; Ortis, F ; Cardozo, Ak ; Bugliani, M ; Marchetti, P ; Eizirik, DL ; Cnop, M

Cell Death and Differentiation, v. 21, p. 1313-1324, 2014

Metabolic Memory of ß-Cells Controls Insulin Secretion and is Mediated by CaMKII

Santos, GJ; Ferreira, SM; Ortis, F; Rezende, L; Li, C; Naji, A; Carneiro, EM; Kaestner, KH; AC, Boschero

Molecular Metabolism, p. 484-489, 2014

Augmented β -Cell Function and Mass in Glucocorticoid-Treated Rodents Are Associated with Increased Islet Ir- β /AKT/mTOR and Decreased AMPK/ACC and AS160 Signaling

Protzek, André O. P. ; Costa-Júnior, José M. ; Rezende, Luiz F. ; Santos, Gustavo J. ; Araújo, Tiago Gomes ; Vettorazzi, Jean F. ; Ortis, Fernanda ; Carneiro, Everardo M. ; Rafacho, Alex ; Boschero, Antonio C.

International Journal of Endocrinology, v. 2014, p. 1-14, 2014

Metabolic memory of human islet controls insulin secretion and is mediated by CAMKII

Santos, GJ; Ferreira, SM; Ortis, F; Rezende, LF; Liu, C; Naji, A; Kaestner, KH; AC, Boschero

Congress: CPDM (Congresso Paulista de Diabetes e Metabolismo)

Laboratory of Studies of Mechanisms of β cell death

Publication