Departamento de Parasitologia – ICB

Departamento de Parasitologia

CARSTEN WRENGER

Phone: +55 (11) 2648-8127
Room: 147

Email: cwrenger@icb.usp.br
Currículo Lattes

Unit for Drug Discovery

GROUP MEMBERS

Flavia M Zimbres

Jasmin Lindner

Kamila A Meissner

Marleen Linzke

Natalia M Izui

Soraya Soledad Bosch

Thales Kronenberger

RESEARCH LINE

The Unit for Drug Discovery aims to identify novel drugs and therapeutics to interfere with the metabolism of pathogens and to tackle human diseases

The general research interest is based on drug discovery against infectious diseases as well as against cancer. The aim of discovering new compounds/inhibitors is mediated by several approaches such as rational drug design by exploiting peculiarities of proteins which has been analysed at the structural level or by high throughput screening (HTS) studies against selected proteins of human pathogenic agents that are involved in disease manifestation. Identified compounds are subsequently validated at the biochemical level using enzymatic assays and mutagenic studies of the respective proteins. In addition to the biochemical analysis novel compounds are also verified at the cellular level by employing the transfection technology. The generated transgenic cell lines are afterwards subject for reverse genetic studies as well as protein- and protein-drug-localisation experiments using GFP-reporter proteins or compound-labelling and fluorescence microscopy

PUBLICATIONS

Wrenger C, Müller S (2004). Mol. Microbiol. 53, 103-113

Wrenger C, Eschbach ML, Müller IB, Warnecke D, Walter RD (2005). J. Biol. Chem. 280, 5242-5248

Müller IB*, Wu F*, Bergmann B, Knöckel J, Walter RD, Gehring H, Wrenger C (2009). PLoS ONE 4, e4406

Müller IB, Bergmann B, Groves MR, Couto I, Amaral L, Begley TP, Walter RD, Wrenger C (2009). PLoS ONE  4:e7656

Müller IB, Hyde JE, Wrenger C (2010). Trends Parasitol. 26, 35-43

Müller IB, Knöckel J, Eschbach ML, Bergmann B, Walter RD, Wrenger C (2010). Cell. Microbiol. 12, 677-691

Knöckel J, Müller IB, Butzloff S, Bergmann B, Walter RD, Wrenger C (2012). Biochem. J Disease  443, 397-405

Reeksting SB, Müller IB, Burger PB, Burgos ES, Salmon L, Louw AI, Birkholtz LM, Wrenger C (2013). Biochem. J. Chem. Biol. 449, 175-187

Chan XW*, Wrenger C*, Stahl K, Bergmann B, Winterberg M, Müller IB#, Saliba KJ# (2013). Nature Commun. 4, 2060

Begum A* Drebes J*, Kikhney A, Müller IB, Perbandt M, Svergun D, Wrenger C#, Betzel C#  (2013). D Biol. Crystallogr. 69, 2320-2329

RESEARCH PROJECTS/FUNDING

FAPESP
CAPES
CNPq
BMBF
DAAD
Nuffic

COLLABORATORS

  • Prof. Dr. Alexander Henning Ulrich | IQ/USP, Brazil
  • Prof. Dr. Dr. Christian Betzel | University of Hamburg, Germany
  • Prof. Dr. Eva Liebau | University of Münster, Germany
  • Prof. Dr. Carsten Claussen | European ScreeningPort, Fraunhofer IME, Germany
  • Dr. Matthew R. Groves | University of Groningen, The Netherlands
  • Prof. Dr. Lyn-Marie Birkholtz | University of Pretoria, South-Africa
  • Dr. Kevin Saliba | The Australian National University, Australia