Departamento de Parasitologia – ICB

Departamento de Parasitologia

CLAUDIO ROMERO FARIAS MARINHO

Phone:+55 (11) 3091-7209
Room: 131 – 1st. floor
Email: marinho@usp.br

Currículo Lattes

Personal Site: http://www.researcherid.com/rid/F-7507-2012

Laboratory of Experimental Immunoparasitology

GROUP MEMBERS

Débora da Silva Freitas

Oscar Javier Murillo Gómez

Erika Paula Machado Peixoto

Marcelo Luís Monteiro Pereira

Flávia Afonso Lima

Aramys Silva dos Reis

Bruna Beatriz Pedroza de Melo

Jamille Gregório Dombrowski

Laura Cordeiro Gomes

  • Scientific Initiation
  • lauracg.gomes@gmailcom
  • +55 (11) 3091-7209

Rodrigo Medeiros de Souza

RESEARCH LINE

Immunology and immunopathogenesis of malaria in pregnancy

Every year at least 50 millions pregnant women are exposed to malaria infection. This high incidence is a result of the life threatening conditions of the mother and the developing fetus. Malaria in Pregnancy (MiP) is characterized by the parasite sequestration in the maternal placenta with consequent maternal anemia, uterine growth retardation and decreased of the fetal viability. The high number of risk factors involved in MiP together with the inherent difficulties to study this disease in humans, are the main reasons why the molecular bases of this pathologic dysfunction are still poorly understood. My main interest is identify the molecular and cellular components of innate and acquired immunity, which contribute to the development of MIP in pregnant women.

PUBLICATIONS

DA SILVA, H.B.; FONSECA, R.; CASSADO, A. A.; SALLES, E. M.; MENEZES, M. N.; LANGHORNE, J.; PEREZ, K. R.; CUCCOVIA, I. M.; RYFFEL, B.; BARRETO, V. M.; MARINHO, C.R.F.; BOSCARDIN, S.B.; ÁLVAREZ, J. M.; D’IMPERIO LIMA, M. R.; TADOKORO, C. E. PLoS Pathogens, v. 1, p. 1-24, 2015

BASTOS, M. F.; ALBRECHT, L.; KOZLOWSKI, E. O.; LOPES, S. C.; BLANCO, Y. C.; CARLOS, B. C.; VICENTE, C. P.; WERNECK, C. C.; FERREIRA, M. U.; MARINHO C.R.F.; MOURAO, P. A.; PAVAO, M. S.; COSTA, F.T.M. Antimicrobial Agents and Chemotherapy (Print), v. X, p. 1-33, 2014.

AITKEN, E. H.; NEGRI, E. M.; BARBOZA, R.; D’IMPERIO LIMA, M.R.; ÁLVAREZ, J.M.; MARINHO, C.R.F; CALDINI, E. G.; EPIPHANIO, S. Malaria Journal (Online), v. 13, p. 230, 2014.

ORTOLAN, L.; SERCUNDES, M.; BARBOZA, R.; DEBONE, D.; MURILLO, O.; HAGEN, S.; RUSSO, M.; D’IMPERIO LIMA, M.R.; ÁLVAREZ, J.M.; AMAKU, M.; MARINHO, C.R.F.; EPIPHANIO, S. Mediators of Inflammation, v. 2014, p. 1-12, 2014.

BARBOZA, R. ; REIS, A. S. ; SILVA, L. G. ; HASENKAMP, L. ; PEREIRA, K. R. B. ; CÂMARA, N.O. ; COSTA, F.T.M. ; D’IMPERIO LIMA, M.R. ; ÁLVAREZ, J.M. ; BOSCARDIN, S.B. ; EPIPHANIO, S. ; MARINHO, C.R.F. Infection and Immunity, v. 82, p. 830-838, 2013.

SOUZA, R.M.; ATAÍDE, R.; DOMBROWSKI, J.G.; IPPOLITO, V.; AITKEN, E.H.; NEGREIROS DOVALLE, S.C.; ÁLVAREZ, J.M.; EPIPHANIO, S.; MARINHO, C.R.F. PLoS Neglected Tropical Diseases, v. 7, p. e2071, 2013.

HVIID, L.; MARINHO, C.R.F; STAALSOE, T.; PENHA-GONÇALVES, C. “Of mice and women: rodent models of placental malaria”. Trends in Parasitology, v. 26, p. 412-419, 2010.

EPIPHANIO, S.; CAMPOS, M.G.; PAMPLONA, A.; CARAPAU, D.; PENA, A.C.; MONTEIRO, C.A. A.; FÉLIX, N.; COSTA-SILVA, A.; MARINHO, C. R. F.; DIAS, S.; MOTA, M. M. PLoS Pathogens, v. 6, p. e1000916, 2010.
MARINHO, C.R.F.; NERES, R.; EPIPHANIO, S.; GONÇALVES, L.A.; CATARINO, M.B.; PENHAGONÇALVES, C. Plos One, v. 4, p. e5630, 2009.
NERES, R.; MARINHO, C.R.F.; GONÇALVES L. A.; CATARINO, M. B. & PENHA-GONÇALVES, C. PLoS ONE 3(2), e1608, Feb, 2008. 

RESEARCH PROJECTS/FUNDING

Ongoing Research Support

Grant Title: The role of inflammasome in the pathogenesis of malaria during pregnancy: effects and mechanisms.
Principal Investigator: Claudio Romero Farias Marinho
Funding Organization: The State of São Paulo Research Foundation (FAPESP) – 2014/09964-5
Funded Period: 01/09/2014-31/02/2016
Amount: R$ 267.000,00
Project goal: The main goal of this project is to study pathogenic mechanisms involved in malaria in pregnancy.
Grant Title: Chamada MCTI/CNPq/MS-SCTIE – Decit N° 40/2012 – Neglected Diseases Research
Principal Investigator: Claudio Romero Farias Marinho
Funding Organization: National Council for Scientific and Technological Development (CNPq) – 404213/2012-0
Funded Period: 1/12/2012-31/11/2015
Amount: R$ 150.000,00
Project goal: The main objective of this study is to describe the epidemiological and clinical features of Plasmodium vivax malaria in pregnancy in Acre state (Brazil).
Grant Title: Using the knowledge generated by the study of the immunopathological mechanisms in gestational malaria for the development of vaccines that direct antigens to dendritic cells.
Principal Investigator: Claudio Farias Romero Marinho / Silvia Beatriz Boscardin
Funding Organization: CAPES – AUX-PE-PNPD 2751/2010
Funded Period: 01/2010-01/2015
Amount: R$ 516.000,00
Project goal: The main goal of this project is to develop a pregnancy malaria vaccine.
Grant Title: The prevalence of mutations and the activity levels of the G6PDH in patients diagnosed with Plasmodium spp. in Cruzeiro do Sul, Acre
Principal Investigator: Claudio Farias Romero Marinho
Funding Organization: National Council for Scientific and Technological Development (CNPq) – 475762/2013-4
Funded Period: 11/2013-11/2016
Amount: R$ 32.000,00
Project goal: The main objective of this project is to study the prevalence of G6PD deficiency in Cruzeiro do Sul, Acre.
Grant Title: Support Program to new professors at the University of São Paulo (Start-up program)
Principal Investigator: Claudio Romero Farias Marinho
Funding Organization: University of São Paulo – DR nº201050821481
Funded Period: 2010-2013
Amount: R$ 10.000,00
Project goal: This is an infrastructure modernization project.

Completed Research Support

Grant Title: Young Investigators in Emerging Institutions Award – Study of the immunopathological mechanisms involved in pregnancy-associated malaria.
Principal Investigator: Claudio Romero Farias Marinho
Funding Organization: The State of São Paulo Research Foundation (FAPESP) – 2009/53889-0
Funded Period: 01/03/2010-31/09/2014
Amount: R$ 827.000,00
Project goal: The main goal of this project is to study pathogenic mechanisms involved in malaria in pregnancy.
Grant Title: The role of Toll like receptors (TLRs) in the pregnancy-associated malaria immunopathogenesis
Principal Investigator: Claudio Romero Farias Marinho
Funding Organization: National Council for Scientific and Technological Development (CNPq) – 475771/2009-5
Funded Period: 1/12/2009-31/11/2011
Amount: R$ 20.000,00
Project goal: The main goal of this project was to study the innate immune response in placental malaria.
Grant Title: Thematic Program of Cooperation in Science and Technology Matters – PRO-ÁFRICA – Brazil & Angola
Principal Investigator: Claudio Romero Farias Marinho
Funding Organization: National Council for Scientific and Technological Development (CNPq) – 475771/2009-5
Funded Period: 1/1/2009-1/1/2012
Amount: R$ 30.000,00
Project goal: Promoting international cooperation on science and technology among African countries
Grant Title: CAPES&FCT Program / Study of the immunopathological mechanisms involved in pregnancy-associated malaria
Principal Investigator: Claudio Romero Farias Marinho
Funding Organization: CAPES&FCT 258/2010
Funded Period: 1/1/2010-31/1/2012
Amount: R$ 83.000,00
Project goal: Promoting international cooperation on science and technology between Brazil and Portugal.

COLLABORATORS

Brazilian Collaborators

  • Prof. Dr. José M. A. Mosig | ICB/USP, São Paulo
  • Profa. Dra. Regina D’Ímperio Lima | ICB/USP, São Paulo
  • Prof. Dr. Marcelo Urbano Ferreira | ICB/USP, São Paulo
  • Profa. Dra. Silvia Boscardin | ICB/USP, São Paulo
  • Profa. Dra. Sabrina Epiphanio | FCF/USP, São Paulo
  • Profa. Dra. Karina R. B. Bastos | UNIFESP, Diadema
  • Profa. Dra. Suiane da Costa N. do Valle | UFAC, Acre
  • Prof. Dr. Fabio Trindade Maranhão Costa | UNICAMP, Campinas
  • Profa. Dra Flávia Raquel Fernandes do Nascimento | UFMA, Maranhão
  • Prof. Dr. Marcos G. Grisoto | UNICEUMA, Maranhão
  • Profa. Dra. Elizabeth Soares Fernandes | UNICEUMA, Maranhão

International Colaborators

  • Dra. Maria M. Mota | Instituto de Medicina Molecular, Portugal
  • Dr. Carlos P. Gonçalves | Instituto Gulbenkian de Ciência, Portugal
  • Dr. Carlos Eduardo Tadokoro | Instituto Gulbenkian de Ciência, Portugal
  • Dra. Maria do Rosário Sambo | Universidade Katyavala Bwila, Angola
  • Dra. Marcia C. Castro | Universidade de Harvard, USA
  • Dra. Blandine Franke-Fayard | Universidade de Leiden, Netherlands
  • Dr. Alexandre Macedo de Oliveira | CDC, USA